The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria?

Wang, David

doi:10.1016/j.coviro.2022.101232

Cited by 15 publications

(11 citation statements)

References 23 publications

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“…This matter is of importance for both raw wastewater samples and final effluent samples ( Symonds et al, 2009 ) allowing the implementation of directed and fast public health measures if needed. The interpretation of these results should also be made at light of new existing hypothesis that propose that picobirnavirus is not an animal infectious virus but rather they may infect evolutionarily microorganisms that live and thrive in the gastrointestinal tract ( Wang, 2022 ).…”

Section: Resultsmentioning

confidence: 96%

Mapping human pathogens in wastewater using a metatranscriptomic approach

Carneiro

Pascoal

Semedo

et al. 2023

Environmental Research

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Section: Resultsmentioning

confidence: 96%

Mapping human pathogens in wastewater using a metatranscriptomic approach

Carneiro

Pascoal

Semedo

et al. 2023

Environmental Research

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“…4 B ). It has been suggested that picobirnaviruses may in fact be RNA bacteriophages rather than viruses of eukaryotes ( Krishnamurthy and Wang 2018 ; Wang 2022 ), which may explain why they are largely absent from our eukaryote-derived TSA data sets but abundant in the metagenomic data sets which typically comprise gut metagenomes. This is also consistent with Chen et al (2022) where the virome of metagenomic fecal samples was found to contain many picobirna-like viruses.…”

Section: Resultsmentioning

confidence: 99%

Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets

Olendraitė

Brown

Firth

2023

Molecular Biology and Evolution

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RNA viruses are abundant, highly diverse, and infect all or most eukaryotic organisms. However, only a tiny fraction of the number and diversity of RNA virus species have been catalogued. To cost effectively expand the diversity of known RNA virus sequences we mined publicly available transcriptomic datasets. We developed 77 family-level Hidden Markov Model profiles for the viral RNA dependent RNA polymerase – the only universal “hall-mark” gene of RNA viruses. By using these to search the NCBI Transcriptome Shotgun Assembly database, we identified 5,867 contigs encoding RNA virus RdRps or fragments thereof and analysed their diversity, taxonomic classification, phylogeny and host associations. Our study expands the known diversity of RNA viruses, and the 77 curated RdRp pHMMs provide a useful resource for the virus discovery community.

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“…We note that viruses from the families Narnaviridae and Picobirnaviridae may not directly infect their animal hosts, but rather the fungi and/or bacteria residing within them [ 69 , 70 ]. As members of the Narnaviridae family, for instance, infect a diverse array of hosts such as fungi, plants and protists, they may be useful indicators of other threats to fish health such as from endoparasites or disease-associated fungi [ 15 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

Five Species of Wild Freshwater Sport Fish in Wisconsin, USA, Reveal Highly Diverse Viromes

Ford,

Dunn,

Leis

et al. 2024

Pathogens

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Studies of marine fish have revealed distant relatives of viruses important to global fish and animal health, but few such studies exist for freshwater fish. To investigate whether freshwater fish also host such viruses, we characterized the viromes of five wild species of freshwater fish in Wisconsin, USA: bluegill (Lepomis macrochirus), brown trout (Salmo trutta), lake sturgeon (Acipenser fulvescens), northern pike (Esox lucius), and walleye (Sander vitreus). We analyzed 103 blood serum samples collected during a state-wide survey from 2016 to 2020 and used a metagenomic approach for virus detection to identify known and previously uncharacterized virus sequences. We then characterized viruses phylogenetically and quantified prevalence, richness, and relative abundance for each virus. Within these viromes, we identified 19 viruses from 11 viral families: Amnoonviridae, Circoviridae, Coronaviridae, Hepadnaviridae, Peribunyaviridae, Picobirnaviridae, Picornaviridae, Matonaviridae, Narnaviridae, Nudnaviridae, and Spinareoviridae, 17 of which were previously undescribed. Among these viruses was the first fish-associated coronavirus from the Gammacoronavirus genus, which was present in 11/15 (73%) of S. vitreus. These results demonstrate that, similar to marine fish, freshwater fish also harbor diverse relatives of viruses important to the health of fish and other animals, although it currently remains unknown what effect, if any, the viruses we identified may have on fish health.

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The enigma of picobirnaviruses: viruses of animals, fungi, or bacteria?

Cited by 15 publications

References 23 publications

Mapping human pathogens in wastewater using a metatranscriptomic approach

Mapping human pathogens in wastewater using a metatranscriptomic approach

Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets

Five Species of Wild Freshwater Sport Fish in Wisconsin, USA, Reveal Highly Diverse Viromes

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