The enigma of pyloric stenosis. Some thoughts on the aetiology

Rogers, Ian Munro

doi:10.1111/j.1651-2227.1997.tb08821.x

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…Foveolar hyperplasia after administration of prostaglandins has been implicated in the development of this condition (32). The hypergastrinemia hypothesis proposes that an inherited increase in the number of parietal cells initiates a cycle of increased acid production, repeated pyloric contraction, and delayed gastric emptying (33). Development of IHPS after initiation of feedings, increased postprandial gastrin levels, markedly increased gastric acid secretion in infants with IHPS, and the induction of IHPS in puppies by means of pentagastrin infusion (34) support this hypothesis.…”

Section: Etiologic Considerationsmentioning

confidence: 99%

Infantile Hypertrophic Pyloric Stenosis

2003

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Infantile hypertrophic pyloric stenosis is a common condition affecting young infants; despite its frequency, it has been recognized only for a little over a century, and its etiology remains unknown. Nevertheless, understanding of the condition and of effective treatment have undergone a remarkable evolution in the 20th century, reducing the mortality rate from over 50% to nearly 0%. The lesion is characterized by gastric outlet obstruction and multiple anatomic abnormalities of the pyloric antrum. The antropyloric muscle is abnormally thickened and innervated, and the intervening lumen is obstructed by crowded and redundant mucosa. Recognition of the obstructive role of the mucosa led to discovery of effective surgical treatment. Accurate clinical diagnosis in patients in whom a thickened antropyloric muscle is not readily palpable can be difficult, resulting in delayed diagnosis and can lead to emaciation and electrolyte imbalance, making the patient a suboptimal surgical candidate. Current imaging techniques, particularly sonography, are noninvasive and accurate for identification of infantile hypertrophic pyloric stenosis. Successful imaging requires understanding of anatomic changes that occur in patients with this condition and plays an integral role in patient care. Accurate, rapid, noninvasive imaging techniques facilitate rapid referral of vomiting infants and prompt surgical treatment of more suitable surgical candidates.

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Section: Etiologic Considerationsmentioning

confidence: 99%

Infantile Hypertrophic Pyloric Stenosis

2003

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“…CD34ϩ dendritic fibroblasts have previoulsy been described in various tissues (Lindenmayer and Miettinen, 1995;Nickoloff, 1991;Weiss and Nickoloff, 1993;Yamazaki and Eyden, 1995, 1997.…”

Section: Icc and Cancermentioning

confidence: 99%

“…IHPS has been known for more than a century (Hayes and Goldenberg, 1957) but it remains a puzzling disorder (Rogers, 1997). The genetic susceptibility to develop IHPS seems to be multifactorial (Mitchell and Risch, 1993).…”

Section: Infantile Hypertrophic Pyloric Stenosis (Ihps)mentioning

confidence: 99%

Interstitial cells of Cajal in human gut and gastrointestinal disease

Vanderwinden

Rumessen

1999

Microsc. Res. Tech.

187

149

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“…Manoma, kad įtakos turi įvairūs genetiniai ir aplinkos veiksniai. Įrodyta, kad ligos atsiradimą lemia naujagimių hipergastrinemija ir skrandžio rūgštingumo padidėjimas [6]. Rizikos veiksniais laikomi neišnešiotumas (mažiau 37 gestacijos savaičių) [7], motinos rūkymas nėštumo metu [7,8], naujagimių maitinimas iš buteliuko [9][10][11] ir makrolidų (eritromicino) vartojimas [12,13].…”

Section: įVadasunclassified

Įgimta Hipertrofinė Prievarčio Stenozė: Rizikos Veiksniai, Diagnostika, Gydymas

Skalskis¹

2020

Health Sciences

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Įgimta hipertrofinė prievarčio stenozė (ĮHPS) – tai naujagimių ir pirmųjų mėnesių kūdikių liga, dėl kurios hipertrofavęs prievarčio sienelės raumeninis sluoksnis siaurina prievarčio kanalą ir neleidžia maistui iš skrandžio patekti į dvylikapirštę žarną. Nėra tikslių duomenų apie priežastis, sukeliančias prievarčio raumeninio sluoksnio hipertrofiją. Manoma, kad genetinę predispoziciją turintiems žmonėms, paveiktiems tam tikrų aplinkos veiksnių, išsivysto ĮHPS. Šios patologijos diagnostika dažnai remiasi klinikine išraiška. Radiologiniai, laboratoriniai tyrimai ir provokaciniai testai gali padėti patvirtinti diagnozę. Įgimta hipertrofinė prievarčio stenozė – gydymo reikalinga anomalija, kuri gali būti koreguojama tiek konservatyviu, tiek chirurginiu būdu. Šio darbo tikslas − įvertinti, susisteminti ir išanalizuoti mokslinėje literatūroje pateikiamus duomenis apie įgimtą hipertrofinę prievarčio stenozę, reikšmingus rizikos veiksnius, galinčius turėti įtakos šios patologijos vystymuisi, diagnostikos bei gydymo taktikos ypatumus.

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The enigma of pyloric stenosis. Some thoughts on the aetiology

Cited by 21 publications

References 27 publications

Infantile Hypertrophic Pyloric Stenosis

Infantile Hypertrophic Pyloric Stenosis

Interstitial cells of Cajal in human gut and gastrointestinal disease

Įgimta Hipertrofinė Prievarčio Stenozė: Rizikos Veiksniai, Diagnostika, Gydymas

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