The Enlargement of Abdominal Lymph Nodes Is a Characteristic of Autoimmune Liver Disease

Wang, Yongjuan; Xu, Xi; Ran, Maojuan; Guo, Xiaopei; Zhou, Lu; Wu, Xi; Wang, Bangmao; Zhang, Jie

doi:10.1155/2020/3631625

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Lymphadenopathy was defined as lymph node length > 1 cm, or reduced ratio of the long to short diameter, using ultrasound or high-resolution computed tomography (HRCT). 11 ILD was identified using chest radiographs or HRCT. 12 Fatigue was measured with the fatigue visual analog scale (fVAS), a widely used and accepted generic and unidimensional fatigue instrument: an fVAS score >1 was defined as having fatigue symptoms.…”

Section: Methodsmentioning

confidence: 99%

Hypocomplementemia in Primary Sjogren’s Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients

Zhou¹,

Yuan²

2022

IJGM

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Objective To determine the prevalence of hypocomplementemia in primary Sjogren’s syndrome (pSS) patients and compare the clinical characteristics of patients with and without hypocomplementemia. Methods A retrospective study was conducted in 120 treatment-naive Chinese patients that met the 2012 American College of Rheumatology Classification Criteria for pSS and were followed up for 3 to 24 months. Based on the complement results, patients were divided into four groups: only low C3, only low C4, both low C3 and C4 (double low), normal group. The data on patient demographics, clinical manifestations, laboratory results, disease activity and pharmacologic therapy were collected and compared among the four groups. Results The prevalence of only low C3, only low C4, both low C3 and C4 in pSS patients was 21.7%, 16.7%, and 10%, respectively. The mean age of the four groups was significantly different. Unlike rampant caries and parotitis, the prevalence of dry eyes and dry mouth differed among the four groups. The proportion of patients with anemia, leukocytopenia, lymphadenopathy, hematological involvement and fatigue was significantly higher in the double low group and lower in the normal complement group. The proportion of patients with increased serum IgG was higher in the only low C4 group than in the other groups. Logistic regression revealed that hypocomplementemia was an independent risk factor for lymphadenopathy and leukopenia. The double low group had a significant history of exposure to glucocorticoids and cyclophosphamide, compared with other groups. Conclusion Our study found that the clinical characteristics of pSS patients with hypocomplementemia differed from those without hypocomplementemia. Hypocomplementemia in pSS was associated with hematological involvement, hyper-IgG, lymphadenopathy, and fatigue, contributing to more significant exposure to glucocorticoid and cyclophosphamide.

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Section: Methodsmentioning

confidence: 99%

Hypocomplementemia in Primary Sjogren’s Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients

Zhou¹,

Yuan²

2022

IJGM

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“…Although lymphadenopathy is benign and self-limited in most patients [1], the presence of lymphadenopathy may lead to a diagnosis of malignant, infectious, or inflammatory diseases, such as metastatic cancer, lymphoma, tuberculosis, and amyloidosis [2][3][4]. Abdominal lymphadenopathy, especially perihepatic lymphadenopathy, is frequently present in chronic liver diseases other than malignant neoplastic diseases, including chronic viral hepatitis, autoimmune hepatitis (AIH), primary biliary cholangitis/cirrhosis (PBC), and primary sclerosing cholangitis (PSC) [5][6][7][8][9][10][11][12][13]. In these chronic hepatitis, the size and morphological changes of lymph nodes sometimes reflect the inflammatory activities of the hepatitis [5][6][7][8]13,14].…”

Section: Introductionmentioning

confidence: 99%

Detection of Lymphadenopathy as a Precursor to Autoimmune Liver Diseases Before Clinical Hepatitis Became Apparent: A Report of Two Cases

Okano,

Tanaka,

Matsusaki

et al. 2023

Cureus

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Two patients were incidentally diagnosed with intra-abdominal lymphadenopathy on imaging examinations. Although endoscopic ultrasound-guided fine needle aspiration of these areas of lymphadenopathy was performed, their causes remained undetermined. Neither patients had abnormal hepatic enzyme levels at the time lymphadenopathy was detected, but they developed hepatitis 20 months and five months later, respectively. The laboratory data and/or histopathological findings suggested primary biliary cholangitis/cirrhosis (PBC) and autoimmune hepatitis (AIH), respectively. These two patients were each started on appropriate treatment (ursodeoxycholic acid or prednisolone, respectively), their hepatitis ameliorated, and the hepatic enzyme levels recovered to within the normal ranges. These patients' clinical courses suggest that their lymphadenopathy was associated with PBC or AIH and appeared before the causative hepatitis became clinically apparent. We should consider the possibility of latent autoimmune hepatic diseases in cases with cryptogenic intra-abdominal lymphadenopathy even if there is no clinically apparent hepatitis.

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Advances in clinical detection methods and nanomaterials for autoimmune liver diseases

Chen,

Zhu,

Wang

et al. 2023

Nano TransMed

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The Enlargement of Abdominal Lymph Nodes Is a Characteristic of Autoimmune Liver Disease

Cited by 4 publications

References 29 publications

Hypocomplementemia in Primary Sjogren’s Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients

Hypocomplementemia in Primary Sjogren’s Syndrome: A Retrospective Study of 120 Treatment-Naive Chinese Patients

Detection of Lymphadenopathy as a Precursor to Autoimmune Liver Diseases Before Clinical Hepatitis Became Apparent: A Report of Two Cases

Advances in clinical detection methods and nanomaterials for autoimmune liver diseases

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