The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction

Popov, Aron Frederik; Hinz, José; Schulz, E.C.; Schmitto, Jan D.; Wiese, Christoph H.R.; Quintel, Michael; Seipelt, Ralf; Schoendube, Friedrich A.

doi:10.1016/j.ejcts.2009.04.049

Cited by 22 publications

(17 citation statements)

References 25 publications

(42 reference statements)

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“…Former research suggests that genetic diversity contributes to CSA-AKI. [5][6][7][8][9][10][11][12][13] Perioperative genetics have become an emerging field in recent years as clinicians could be enabled to strengthen existing clinical scores by also considering genetic risk factors predisposing to CSA-AKI.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

et al. 2013

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Objectives: Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short-and long-term outcome. We analyzed two common genetic polymorphisms that have previously been linked to renal failure and inflammation, and have been supposed to be associated with cardiac surgery associated-acute kidney injury (CSA-AKI). Methods: A total of 1415 consecutive patients who underwent elective cardiac surgery with CPB at our institution were prospectively enrolled. Patients were genotyped for Apolipoprotein E (ApoE E2,E3,E4) (rs429358 and rs7412) and TNF-a-308 G4A (rs1800629). Results: Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between ApoE (E2,E3,E4) and TNF-a-308 G4A genotypes and the RIFLE criteria could be detected. Several multiple linear regression analyses for postoperative creatinine increase revealed highly significant associations for aortic cross clamp time (p50.001), CPB-time (p50.001), norepinephrine (p50.001), left ventricular function (p ¼ 0.004) and blood transfusion (p50.001). No associations were found for ApoE (E2,E3,E4) and TNF-a-308 G4A genotypes or baseline creatinine. When the sample size is 1415, the multiple linear regression test of R 2 ¼ 0 for seven covariates assuming normal distribution will have at least 99% power with significance level 0.05 to detect an R 2 of 0.108 or 0.107 as observed in the data. Conclusions: ApoE (E2,E3,E4) polymorphism and the TNF-a-308 G4A polymorphism are not associated with renal injury after CPB.

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Section: Introductionmentioning

confidence: 99%

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

et al. 2013

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“…We hypothesize that the effects of rs7830 on ESRD might be due to NOS3 rather than ATG9B . In fact, polymorphisms in NOS3 have been associated with atherosclerotic vascular diseases [24], renal dysfunction [25], and advanced diabetic nephropathy [26]. Moreover, this SNP seems to be located within a silencer motif (TGG G GACT) [27], where the G to T allele change could disturb the splicing mechanism in NOS3 leading to different transcripts [28].…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study

et al. 2012

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BackgroundChronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These markers are also elevated in end-stage renal disease (ESRD), which constitutes a serious public health problem.ObjectiveTo investigate whether single nucleotide polymorphisms (SNPs) located in genes related to immune and inflammatory processes, could be associated with ESRD development.Design and methodsA retrospective case-control study was carried out on 276 patients with ESRD and 288 control subjects. Forty-eight SNPs were genotyped via SNPlex platform. Logistic regression was used to assess the relationship between each sigle polymorphism and the development of ESRD.ResultsFour polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model). After adjusting for multiple testing, results lost significance.ConclusionOur preliminary data suggest that four genetic polymorphisms located in genes related to inflammation and immune processes could help to predict the risk of developing ESRD.

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“…Popov et al 18 encontraron en 497 pacientes de raza blanca, adultos, sometidos a cirugía de revascularización miocár-dica, que el alelo C del SNP eNOS -786 se asoció a una disminución en el aclaramiento de creatinina postoperatoria (55,8 ± 31,3 vs 62,1 ± 35,8; P: 0,004) y a un aumento en la necesidad de técnicas de reemplazo renal. En este estudio se excluyeron los individuos mayores de 80 años con enfermedad neoplásica conocida, en diálisis crónica o trasplantados.…”

Section: Sintasa De óXido Nítrico Endotelial (Enos)unclassified

Determinantes genéticos del riesgo y pronóstico del daño renal agudo: una revisión sistemática

et al. 2012

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The eNOS 786C/T polymorphism in cardiac surgical patients with cardiopulmonary bypass is associated with renal dysfunction

Cited by 22 publications

References 25 publications

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study

Determinantes genéticos del riesgo y pronóstico del daño renal agudo: una revisión sistemática

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