The enrichment of cancer stem cells using composite alginate/polycaprolactone nanofibers

Hu, Wei Wen; Lin, Chih‐Ming; Hong, Zhen Jie

doi:10.1016/j.carbpol.2018.10.087

Cited by 34 publications

(14 citation statements)

References 60 publications

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“…Other Synthetic Biomaterials-Other commonly studied synthetic biomimetic materials are polydimethylsiloxane (PDMS), polycaprolactone (PCL), and polyurethane (PUR) films. 51,75,97 All of these materials allow for a higher degree of stiffness matching of tissues and organs compared to natural biomaterials, and they can also be functionalized or mixed with ECM components to form hybrid materials that can model the tumor microenvironment. 97 One notable example evaluates the development of porous and tunable alginate-PCL nanofiber scaffolds for investigating cancer stem-like cell enrichment, EMT, and cell distribution.…”

Section: Synthetic Materialsmentioning

confidence: 99%

Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior

2019

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Cancer is one of the leading causes of death both in the United States and worldwide. The dynamic microenvironment in which tumors grow consists of fibroblasts, immune cells, extracellular matrix (ECM), and cytokines that enable progression and metastasis. Novel biomaterials that mimic these complex surroundings give insight into the biological, chemical, and physical environment that cause cancer cells to metastasize and invade in to other tissues. Twodimensional (2D) cultures are useful for gaining limited information about cancer cell behavior; however, they do not accurately represent the environments that cells experience in vivo. Recent advances in the design and tunability of diverse three-dimensional (3D) biomaterials complement biological knowledge and allow for improved recapitulation of in vivo conditions. Understanding cell-ECM and cell-cell interactions that facilitate tumor survival will accelerate the design of more effective therapies. This review discusses innovative materials currently being used to study tumor and immune cell behavior and interactions, including materials that mimic the ECM composition, mechanical stiffness, and integrin binding sites of the tumor microenvironment.

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Section: Synthetic Materialsmentioning

confidence: 99%

Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior

2019

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“…The combination of alginate and other polymers was found to improve the cell adhesion, chemical stability, and mechanical properties of the resulting blended composite material [25,49,[51][52][53]. Elsewhere, alginate and polycaprolactone (PCL) were co-blended by the dual jet electrospinning system of their mixture with PEO onto a mandrel collector in order to facilitate cell adhesion onto the nanofibers [52,54]. It was demonstrated that the fibers, having different ratios (alginate: PCL), can be achieved by changing the feeding rate of the polymer jets.…”

Section: Advanced Electrospinning Techniquesmentioning

confidence: 99%

“…Electrospun nanofibers as a template to encapsulate or immobilize the vectors offers a novel route to control their release rate toward targeted sites, as recently reviewed by [80]. Hu and co-workers from the National Central University electrospun alginate with the aid of PEO (while adding PCL to overcome the limited cell adhesion for alginate-based materials) for gene delivery systems [53,54,58]. The immobilization of the genes was achieved by exploiting anionic character of alginate to form a polycomplex with cationic nonviral vectors e.g., polyethyleneimine (PEI) and chitosan via electrostatic interaction.…”

Section: Delivery Systemsmentioning

confidence: 99%

Electrospun Alginate Nanofibers Toward Various Applications: A Review

et al. 2020

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Alginate has been a material of choice for a spectrum of applications, ranging from metal adsorption to wound dressing. Electrospinning has added a new dimension to polymeric materials, including alginate, which can be processed to their nanosize levels in order to afford unique nanostructured materials with fascinating properties. The resulting nanostructured materials often feature high porosity, stability, permeability, and a large surface-to-volume ratio. In the present review, recent trends on electrospun alginate nanofibers from over the past 10 years toward advanced applications are discussed. The application of electrospun alginate nanofibers in various fields such as bioremediation, scaffolds for skin tissue engineering, drug delivery, and sensors are also elucidated.

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“…In comparison to the pristine agarose, the electrospun fibrous agarose/PAAm demonstrated 66.66% enhancement in the strength [44]. Similarly, electrospinning of alginate is being carried out for a number of applications [45]. Alginate is an important biopolymer with vast potential [46].…”

Section: Introductionmentioning

confidence: 99%

Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

et al. 2019

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Innovative solutions using biopolymer-based materials made of several constituents seems to be particularly attractive for packaging in biomedical and pharmaceutical applications. In this direction, some progress has been made in extending use of the electrospinning process towards fiber formation based on biopolymers and organic compounds for the preparation of novel packaging materials. Electrospinning can be used to create nanofiber mats characterized by high purity of the material, which can be used to create active and modern biomedical and pharmaceutical packaging. Intelligent medical and biomedical packaging with the use of polymers is a broadly and rapidly growing field of interest for industries and academia. Among various polymers, alginate has found many applications in the food sector, biomedicine, and packaging. For example, in drug delivery systems, a mesh made of nanofibres produced by the electrospinning method is highly desired. Electrospinning for biomedicine is based on the use of biopolymers and natural substances, along with the combination of drugs (such as naproxen, sulfikoxazol) and essential oils with antibacterial properties (such as tocopherol, eugenol). This is a striking method due to the ability of producing nanoscale materials and structures of exceptional quality, allowing the substances to be encapsulated and the drugs/ biologically active substances placed on polymer nanofibers. So, in this article we briefly summarize the recent advances on electrospinning of biopolymers with particular emphasis on usage of Alginate for biomedical and pharmaceutical applications.

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The enrichment of cancer stem cells using composite alginate/polycaprolactone nanofibers

Cited by 34 publications

References 60 publications

Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior

Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior

Electrospun Alginate Nanofibers Toward Various Applications: A Review

Biopolymers for Biomedical and Pharmaceutical Applications: Recent Advances and Overview of Alginate Electrospinning

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