2023
DOI: 10.3389/fimmu.2023.1270981
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The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature

Albina Fejza,
Greta Carobolante,
Evelina Poletto
et al.

Abstract: IntroductionImmune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer therapy as single agents or in combination regimens both in adults and children. Unfortunately, ICIs provide a long-lasting therapeutic effect in only one third of the patients. Thus, the search for predictive biomarkers of responsiveness to ICIs remains an urgent clinical need. The efficacy of ICIs treatments is strongly affected not only by the specific characteristics of cancer cells and the levels of immune checkpoint l… Show more

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Cited by 3 publications
(1 citation statement)
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“…14 Instead of vasculature, remodeling the extracellular matrix (ECM) is another method to improve immune infiltration. 66 The dense ECM can also inhibit oxygen flow, preventing the successful ROS generation PDT relies on. 67 To execute such ECM remodeling, microneedle patches were recently formulated with hyaluronidases (HAases) to degrade HA in the TME/ECM.…”
Section: Co-delivery Icd-inducing Pitmentioning
confidence: 99%
“…14 Instead of vasculature, remodeling the extracellular matrix (ECM) is another method to improve immune infiltration. 66 The dense ECM can also inhibit oxygen flow, preventing the successful ROS generation PDT relies on. 67 To execute such ECM remodeling, microneedle patches were recently formulated with hyaluronidases (HAases) to degrade HA in the TME/ECM.…”
Section: Co-delivery Icd-inducing Pitmentioning
confidence: 99%