The enterocolitis of Hirschsprung's disease

Bill, Alexander H.; Chapman, Niles D.

doi:10.1016/0002-9610(62)90016-8

Cited by 155 publications

(44 citation statements)

References 11 publications

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“…It is postulated that the increased length of aganglionic bowel implies a greater proximal obstruction with greater intraluminal pressure, increased bacterial stasis and proximal dilation. However, other studies on this condition report no difference regarding the length of the aganglionic bowel and occurence of enterocolitis [15,20,24].…”

Section: Mechanical Obstructionmentioning

confidence: 92%

“…This suggests that enterocolitis only occurs in dilated ganglionic proximal bowel [20,21]. However, this theory does not explain the enterocolitis that occurs in distal colon with a defunctioning proximal stoma and the occurrence of enterocolitis in post-operative patients or histological evidence of enterocolitis in aganglionic bowel [10,11].…”

Section: Mechanical Obstructionmentioning

confidence: 98%

“…Bill and Chapman [20] argued in 1962 that partial mechanical obstruction was pathogenetic for HAEC causing mechanical dilatation of the proximal bowel leading to faecal loading and stasis resulting in further dilatation thus mucosal ischaemia and bacterial invasion which was cured by colostomy. This suggests that enterocolitis only occurs in dilated ganglionic proximal bowel [20,21].…”

Section: Mechanical Obstructionmentioning

confidence: 98%

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New insights into the pathogenesis of Hirschsprung’s associated enterocolitis

Murphy

Puri

2005

Ped Surgery Int

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The management of Hirschsprung's disease (HD) has made dramatic strides over the last 20 years. Research into the embryological development and migration of ganglion cell has enabled a greater understanding of the pathogenesis of the disease. Coupled with new techniques in surgery, such as laparoscopy-assisted pull-through and the transanal pull-through, this knowledge has led to improved outcomes for children with HD. However, although our appreciation of Hirschsprung's associated enterocolitis and its aetiology has increased, there are continued references in the literature to a multitude of theories of pathogenesis. The purpose of this review is to delineate the theories and demonstrate the evidence supporting or otherwise contradicting each other.

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Section: Mechanical Obstructionmentioning

confidence: 92%

Section: Mechanical Obstructionmentioning

confidence: 98%

Section: Mechanical Obstructionmentioning

confidence: 98%

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New insights into the pathogenesis of Hirschsprung’s associated enterocolitis

Murphy

Puri

2005

Ped Surgery Int

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“…In addition, there have been reports of colonic ulceration and inflammatory changes proximal to carcinoma [6, 11 14], and other obstructive lesions such as adhesions [3,15], Hirschsprung's disease [16,17], and an incarcerated inguinal hernia [18], The etiology of these changes in the colonic mucosa proximal to the obstructive lesion is obscure. In most of the reported cases, ischemia has not been considered as a causative factor because at laparotomy there was no evidence of extra-visceral vascular impairment of the bowel.…”

Section: Discussionmentioning

confidence: 99%

Ischemic colitis associated with carcinoma of the colon

Whitehouse

Watt

1977

Gastrointest Radiol

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Two cases of ischemic colitis occurring proximal to carcinoma of the colon are described, with special reference to the barium enema and pathological findings. The association of these two conditions is rare but when present may cause some confusion. It is possible that the two lesions may, for instance, be considered to be both due to ischemic colitis, or mistaken for granulomatous colitis with a stricture.

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“…constantly thickened and blunted mucosal folds in atonic bowel loops (Fig. 1), suggested enterocolitis, especially in combination with fluid levels [15]. Stretching of loops, resulting from swallowing air into an obstructed gut, would, in our opinion, signify only intact bowel function.…”

Section: Non-discriminating Parametersmentioning

confidence: 99%

Plain film diagnosis in meconium plug syndrome, meconium ileus and neonatal Hirschsprung's disease

et al. 1991

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Abstract. Abdominal plain films of 133 neonates, with82 cases of meconium plug syndrome (MPS), 27 cases of meconium ileus (MI) and 24 cases of neonatal Hirschsprung's disease (HI)), were reviewed to assess the value of such radiographs for diagnosis. The radiographs were examined according to a list of 11 parameters. By using multivariate discriminant analysis, it appeared that 4 parameters i.e. dilatation of bowel loops, varying loop calibre, fluid levels and colonic gas were most important in discriminating among the three disorders. For each parameter the weight (in points) was derived. To classify patients, three group-scores had to be calculated: the group-score with the largest value indicated the most likely disorder. So in 99 %, 88 % and 63 % of MPS, HD and MI, respectively, an accurate diagnosis could be predicted. The overall diagnostic accuracy was 89 %. Such a diagnosis can be a sound basis for further investigation.

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The enterocolitis of Hirschsprung's disease

Cited by 155 publications

References 11 publications

New insights into the pathogenesis of Hirschsprung’s associated enterocolitis

New insights into the pathogenesis of Hirschsprung’s associated enterocolitis

Ischemic colitis associated with carcinoma of the colon

Plain film diagnosis in meconium plug syndrome, meconium ileus and neonatal Hirschsprung's disease

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