The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases

Abstract

Aging, a fundamental physiological process influenced by innumerable biological and genetic pathways, is an important driving factor for several aging‐associated disorders like diabetes mellitus, osteoporosis, cancer, and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. In the modern era, the several mechanisms associated with aging have been deeply studied. Treatment and therapeutics for age‐related diseases have also made considerable advances; however, for the effective and long‐lasting treatment, nutritional therapy particularly including dietary polyphenols from the natural origin are endorsed. These dietary polyphenols (e.g., apigenin, baicalin, curcumin, epigallocatechin gallate, kaempferol, quercetin, resveratrol, and theaflavin), and many other phytochemicals target certain molecular, genetic mechanisms. The most common pathways of age‐associated diseases are mitogen‐activated protein kinase, reactive oxygen species production, nuclear factor kappa light chain enhancer of activated B cells signaling pathways, metal chelation, c‐Jun N‐terminal kinase, and inflammation. Polyphenols slow down the course of aging and help in combatting age‐linked disorders. This exemplified in the form of clinical trials on specific dietary polyphenols in various aging‐associated diseases. With this context in mind, this review reveals the new insights to slow down the aging process, and consequently reduce some classic diseases associated with age such as aforementioned, and targeting age‐associated diseases by the activities of dietary polyphenols of natural origin.

Molecular mechanism of Achyranthis bidentatae radix and Morindae officinalis radix in osteoporosis therapy: An investigation based on network pharmacology, molecular docking, and molecular dynamics simulations

“…A large number of previous studies have explored the application and molecular mechanism of quercetin and kaempferol as monomer drugs in the treatment of OP [ [20] , [21] , [22] , [23] ]. TCM emphasizes the compatibility of various herbs, and different DAIs play different roles in disease treatment.…”

Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

“…Nutrition is assumed to have an influence over the epigenetic mechanisms, which are effective in the pathogenesis of age-related diseases [ 29 ]. Dietary polyphenols have been recognized as efficient agents against aging and aging-related disorders [ 30 ]. A diet rich in vegetables and fruits has been found to prevent many diseases and to prolong lifespan.…”

“…A diet rich in vegetables and fruits has been found to prevent many diseases and to prolong lifespan. It has also been demonstrated that the beneficial effect on longevity is due to a high content of polyphenols in the diet, indicating a direct relationship between polyphenol consumption and increased lifespan [ 30 ]. Recent findings indicate that phytochemicals like quercetin, resveratrol, curcumin, and fisetin regulate the activity of sirtuins [ 31 ] [ 32 ].…”

Urolithin B protects mice from diet-induced obesity, insulin resistance, and intestinal inflammation by regulating gut microbiota composition

“…10 Therefore, the consumption of polyphenol-rich foods has been shown to reduce the incidence of metabolic disorders, obesity, and T2D. 11 However, certain dietary polyphenols remain in the intestine for extended periods, allowing them to exert their beneficial effects by influencing the composition of the gut microbiota. 12 Increasing evidence from both human and animal studies indicates that specific polyphenols can alter the composition of the gut microbial community.…”