Amazing possibility on the one hand and frustrating inaction on the other, that is the yin and yang of modern science (Ness, 2014). The fact that we can build devices that implement the same basic operations as those the nervous system uses leads to the inevitable conclusion that we should be able to build entire systems based on the organizing principles used by the nervous system. Nevertheless, the human brain is at least a factor of 1 billion more efficient than our present digital technology, and a factor of 10 million more efficient than the best digital technology that we can imagine (Fiorini, 2015a). The unavoidable conclusion is that we have something fundamental to learn from the brain and biology about new ways and much more effective forms of computation and information managing. We need revisiting our fundamental research tools and reinventing our scientific ecosystem to enhance relational competence (L'Abate et al., 2010) for real innovation vital development, towards a more sustainable economy and wellbeing (Fiorini et al., 2016). Scientists as well as laymen do ignore evidence incompatible with their preconceptions. We need tools able to manage ontological uncertainty quite more effectively than in the past (Fiorini