The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

Angelis, Cristina de; Galdiero, Mariano; Pivonello, Claudia; Salzano, Ciro; Gianfrilli, Daniele; Piscitelli, Prisco; Lenzi, Andrea; Colao, Annamaria; Pivonello, Rosario

doi:10.1016/j.reprotox.2017.07.021

Cited by 212 publications

(128 citation statements)

References 220 publications

(279 reference statements)

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“…Similar results were obtained by other study using pesticides that induced severe degenerative changes in seminiferous tubules [23]. Metals, such as Cd and Hg, also induced structural alterations in the testis structure, including damage in the vascular endothelium and in the BTB integrity and necrosis and disintegration of spermatocytes [27,33]. In general, these animal studies showed that EDCs induced changes in testicular morphology, which may be a reason for the decline of male fertility.…”

Section: Alterations In Testicular Morphologysupporting

confidence: 86%

“…Cd decreased sperm motility and sperm viability and induced detrimental effects on spermatozoa metabolism by inhibition of the activity of glycogen phosphorylase, glucose-6-phosphatase, fructose-1,6-diphosphatase, glucose-6-phosphate isomerase, amylase, Mg 2+ − dependent ATPase and lactic and succinic acid dehydrogenases. As reviewed by de Angelis et al [33], significant negative correlations were found between Cd levels and semen parameters, including total sperm count, concentration, motility and morphology. Results from a meta-analysis indicate that men with low fertility had higher semen Pb and Cd levels and lower semen Zn levels [67].…”

Section: Effects Of Edcs On Sperm Production Morphology Motility Anmentioning

confidence: 83%

“…Cd also induces testicular dysfunction, which results of the functional impairment of SC and LC. Regarding human studies, the effect of Cd exposure to male endocrine function was assessed by several authors (as reviewed by de Angelis et al [33]). The results obtained are controversial; some authors found that Cd concentrations were positively correlated with FSH, T, E 2 , LH and inhibin B and negatively correlated with prolactin [29,44].…”

Section: Testicular Dysfunction Due To Edc Exposurementioning

confidence: 99%

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The Role of Endocrine-Disrupting Chemicals in Male Fertility Decline

Henriques¹,

Loureiro²,

Fardilha³

et al. 2020

Male Reproductive Health

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Endocrine-disrupting chemicals (EDCs) are exogenous compounds with natural or anthropogenic origin omnipresent in the environment. These compounds disrupt endocrine function through interaction with hormone receptor or alteration of hormone synthesis. Humans are environmentally exposed to EDCs through the air, water, food and occupation. During the last decades, there has been a concern that exposure to EDCs may contribute to an impairment of human reproductive function. EDCs affect male fertility at multiple levels, from sperm production and quality to the morphology and histology of the male reproductive system. It has been proposed that exposure to EDCs may contribute to an impairment of sperm motility, concentration, volume and morphology and an increase in the sperm DNA damage. Moreover, EDCs exert reproductive toxicity inducing structural damage on the testis vasculature and blood-testis barrier and cytotoxicity on Sertoli and Leydig cells. This chapter will explore the effects of EDCs in male reproductive system and in the decline of male fertility.

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Section: Alterations In Testicular Morphologysupporting

confidence: 86%

Section: Effects Of Edcs On Sperm Production Morphology Motility Anmentioning

confidence: 83%

Section: Testicular Dysfunction Due To Edc Exposurementioning

confidence: 99%

See 1 more Smart Citation

The Role of Endocrine-Disrupting Chemicals in Male Fertility Decline

Henriques¹,

Loureiro²,

Fardilha³

et al. 2020

Male Reproductive Health

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“…Among the categories of pollutants in the environment, heavy metals represent one of the most common. Also, their wide use in the industry represents a threat to human health because of their long‐term persistence in the environment and bio‐accumulation (de Angelis et al, 2017; Nawrot et al, 2010). Cadmium (Cd) is a heavy metal, also known as an endocrine disruptor, toxic to humans, and, more important, classified as carcinogenic to humans (Group 1; Jarüp & Akesson, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, all the cellular population of testicular tissue can be affected by Cd, including decrease in the number and aberrant morphology of spermatogonia and spermatocytes (Marettová et al, 2015), along with Sertoli cell actin and/or microtubule‐based cytoskeleton alterations (N. Li, Mruk, Lee, Wong, & Cheng, 2016; Xiao et al, 2014). Moreover, many studies have correlated Cd exposure to reduced male fertility, as shown by poor semen quality and decreased sperm count (Benoff, Jacob, & Hurley, 2000; de Angelis et al, 2017; De Franciscis et al, 2015; Y. Li, Wu, Zhou, & Gao, 2016; Pant, Kumar, Upadhyay, Gupta, & Chaturvedi, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cadmium‐induced toxicity increases prolyl endopeptidase (PREP) expression in the rat testis

Venditti

Chemek²,

Minucci

et al. 2020

Molecular Reproduction Devel

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During the differentiation of the male gamete, there is a massive remodeling in the shape and architecture of all the cells of the seminiferous epithelium. The cytoskeleton, as well as many associated proteins with it, plays a pivotal role in this process. The testis is particularly susceptible to environmental pollutant, which can lead to injury and impairment of normal spermatozoa production. Cadmium (Cd) is one of the major chemical environmental toxicants in economically developed countries. Food and cigarettes are the main sources of exposure to this element.Here, the protective role of zinc (Zn) to prevent the testicular toxicity in male adult rats after prenatal and during lactation exposure to Cd has been assessed. Altered testicular histology at the interstitial and germinal levels was found, whereas Zn supply completely corrected Cd toxicity. Moreover, the effects of these metals on the testicular expression and localization of the protease prolyl endopeptidase (PREP) were evaluated. Interestingly, the results showed an increase of PREP messenger RNA and protein. Data were corroborated by immunofluorescence. This study raises the possibility of using PREP as a new fertility marker. K E Y W O R D Scadmium, endocrine disruptor, PREP, testis, zinc

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Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

Bhardwaj

Panchal

2021

Environ and Mol Mutagen

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Cadmium (Cd), an environmental toxic heavy metal, has been reported to cause testicular toxicity, which contributes to the recent decline in male fertility worldwide. Quercetin (Qcn), a major dietary antioxidant, has been shown to have protective effects under various pathological conditions. However, whether Qcn provides protection against Cd‐stimulated testicular toxicity remains obscured. The present study was therefore aimed at investigating the ameliorative effect of Qcn supplementation on Cd‐induced toxicity in the goat testis in vitro in a dose‐(10, 50, and 100 μM) and time‐dependent (4 and 8 h) manner. Different cytotoxicity, genotoxicity, and biochemical analyses have been carried out using appropriate methods. Cytotoxicity in testicular cells induced by Cd treatment was apparently mitigated by Qcn treatment, evidenced by decreased apoptotic attributes or frequency in Qcn plus Cd‐treated groups compared to the only Cd‐treated groups. Qcn treatment provides substantial protection to the Cd‐triggered aggression in oxidative (increased MDA levels) and total antioxidant capacity (reduced FRAP activity) in testicular tissue, indicating the anti‐oxidative function of Qcn against Cd exposure. Moreover, Cd‐induced decline in antioxidant status (CAT, SOD, and GST activity) was markedly restored by Qcn supplementation in testicular tissue. In conclusion, this study shows that Qcn treatment significantly attenuated the Cd‐evoked testicular damage, suggesting its beneficial potential in preventing or at least in managing the gonadotoxicity in males induced by steadily increasing Cd contamination in the environment.

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The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

Cited by 212 publications

References 220 publications

The Role of Endocrine-Disrupting Chemicals in Male Fertility Decline

The Role of Endocrine-Disrupting Chemicals in Male Fertility Decline

Cadmium‐induced toxicity increases prolyl endopeptidase (PREP) expression in the rat testis

Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

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