The Environment and Reproductive Health (EARTH) Study: a prospective preconception cohort

Messerlian, Carmen; Williams, Paige L.; Ford, Jennifer B.; Chavarro, Jorge E.; Mínguez-Alarcón, Lidia; Dadd, Ramace; Braun, Joseph M.; Gaskins, Audrey J.; Meeker, John D.; James‐Todd, Tamarra; Chiu, Yu‐Han; Nassan, Feiby L.; Souter, Irene; Petrozza, John C.; Keller, M.; Toth, Thomas L.; Calafat, Antònia M.; Hauser, Russ; Team, Earth Study

doi:10.1093/hropen/hoy001

Cited by 101 publications

(66 citation statements)

References 46 publications

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“…Eligible women (18-46 years) presenting at the Massachusetts General Hospital (MGH) Fertility Center were invited to enroll in the Environment and Reproductive Health (EARTH) Study, an ongoing prospective cohort aimed at identifying determinants of fertility (2004-present). 12 Approximately 55% of women referred by physicians ultimately enroll in the study; however, among referred women who research nurses are able to contact, 78% enroll in the study. A food frequency questionnaire (FFQ) was introduced in 2007.…”

Section: Materials and Methods Study Populationmentioning

confidence: 99%

Dietary patterns and outcomes of assisted reproduction

Gaskins

Nassan

Chiu

et al. 2019

American Journal of Obstetrics and Gynecology

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Background.-There is growing acceptance that nutrition may be related to fertility, and specifically to ART success in women; however, there is still no specific dietary guidance. Objective.-To evaluate the relationship between pre-treatment adherence to various dietary patterns and outcomes of assisted reproductive technologies (ART). Study Design.-We followed 357 women enrolled in the prospective Environment and Reproductive Health (EARTH) Study, who underwent 608 ART cycles (2007-2017). Using a validated food frequency questionnaire completed prior to treatment, we assessed adherence to the Mediterranean Diet (MedDiet), the alternate Healthy Eating Index 2010 (aHEI2010), the Fertility Diet (FD) (developed based on risk factors for anovulatory infertility), and a "pro-fertility" diet we developed based on factors previously related to ART outcomes (higher intake of supplemental

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Section: Materials and Methods Study Populationmentioning

confidence: 99%

Dietary patterns and outcomes of assisted reproduction

Gaskins

Nassan

Chiu

et al. 2019

American Journal of Obstetrics and Gynecology

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“…The cohort has been described elsewhere. 36 In brief, women aged 18 to 46 years and men aged 18 to 55 years, using their own gametes, were eligible. Participants enrolled independently or as a couple and were followed up from study entry through their fertility care, pregnancy, and labor and delivery.…”

Section: Study Cohortmentioning

confidence: 99%

Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth

et al. 2020

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IMPORTANCE Although phthalate exposure during pregnancy has been associated with preterm birth, the association of preconception exposure in either parent with preterm birth constitutes a knowledge gap. OBJECTIVE To examine the association of paternal and maternal preconception urinary concentrations of biomarkers of phthalates and phthalate substitutes with singleton preterm birth. DESIGN, SETTING, AND PARTICIPANTS This study, conducted at an academic fertility center in Boston, Massachusetts, included a prospective preconception cohort of subfertile couples comprising 419 mothers and 229 fathers and their 420 live-born singleton offspring born between

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“…Women between the ages of 18 and 46 years are eligible to enroll and are followed from study entry, throughout their fertility care, eventual pregnancy, and birth. Details of the cohort have been described elsewhere (27). The present study included women who enrolled in the EARTH Study with a male partner between November 2004 and October 2015 and for whom we had at least one urine sample analyzed for the measurement of flame retardant metabolite concentrations during an IVF cycle (fresh or cryo/frozen).…”

Section: Study Cohortmentioning

confidence: 99%

Organophosphate flame-retardant metabolite concentrations and pregnancy loss among women conceiving with assisted reproductive technology

Messerlian

Williams

Mínguez-Alarcón

et al. 2018

Fertility and Sterility

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Objective: To evaluate whether urinary concentrations of organophosphate flame retardant (PFR) metabolites are associated with pregnancy loss among women conceiving with assisted reproductive technology (ART). Design: Prospective preconception cohort of subfertile women. Setting: Academic hospital fertility center in Boston, Massachusetts. Patient(s): A total of 155 women conceiving 179 pregnancies with ART. Intervention(s): None. Mean exposure to each of five PFR metabolites was estimated by averaging the specific-gravity adjusted natural log concentrations from two urine samples collected during the ART cycle of conception. Main Outcome Measure(s): Adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for biochemical and total pregnancy loss (all losses <20 weeks' gestation) by quartiles of PFR metabolite concentrations were estimated using a repeated measures log-binomial model, accounting for multiple pregnancies per woman. Result(s): Of the 179 pregnancies, 31% ended in pregnancy loss (12% in biochemical loss). Among the three metabolites with high detection frequency [bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), diphenyl phosphate (DPHP), and isopropylphenyl phenyl phosphate (ip-PPP)], an increased risk of biochemical loss was observed for women with DPHP concentrations in the fourth vs. first quartile (RR 1.64; 95% CI 0.61-4.39). Also found was an elevated risk of biochemical pregnancy loss among women in the highest quartile of the molar sum of urinary PFR metabolites compared with the lowest (RR 1.89; 95% CI 0.64-5.58). Urinary concentrations of ip-PPP and BDCIPP were not associated with either outcome. Conclusion(s): Among subfertile women, urinary DPHP metabolite concentrations measured during the ART cycle of conception may be associated with early pregnancy loss. Although this study is uniquely designed to investigate early markers of pregnancy success and maintenance, the small sample size likely contributed to imprecision. Given their increasing use as replacement chemicals for traditional flame retardants, exposure to PFRs may increase, and more studies will be needed to investigate their potential to impact pregnancy and reproduction. (Fertil Steril Ò 2018;110:1137-44. Ó2018 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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The Environment and Reproductive Health (EARTH) Study: a prospective preconception cohort

Cited by 101 publications

References 46 publications

Dietary patterns and outcomes of assisted reproduction

Dietary patterns and outcomes of assisted reproduction

Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth

Organophosphate flame-retardant metabolite concentrations and pregnancy loss among women conceiving with assisted reproductive technology

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