The EP-score to assess treatment efficacy in RRMS patients: a preliminary study

Margaritella, Nicolò; Mendozzi, Laura; Garegnani, Massimo; Nemni, Raffaello; Gilardi, Emanuele; Pugnetti, Luigi

doi:10.3109/00207454.2014.904305

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…After steroid treatment, rapid changes in the excitability of the motor cortex can be observed 44 . EDSS did not reflect any changes after treatment with interferon beta and Glatiramer, but VEP scores improved in the Interferon beta group 35 . It is worth noting that other studies and treatments show no significant changes in electrophysiological changes 10, 12, 32 .…”

Section: Resultsmentioning

confidence: 71%

“…In the same vein, the second most frequently investigated evoked potential in EEG is MEP, whose latency, amplitude and any detected abnormalities have extensively been analysed and investigated 14,20,21,25,31,32,[38][39][40][41][42][43][44][45] . Interestingly, SSEPs 10,17,20,21,28,35,36,43,[46][47][48] and AEPs 8,16,17,28 were less common and frequently used in the reviewed studies, but still offer, when combined with other evoked potentials, solid composite scores. Similarly, authors in 49,50 investigated and analysed evoked related potential (ERP) responses in MS patients by using the two-tone oddball paradigm.…”

Section: Eeg and Evoked Potentialsmentioning

confidence: 99%

See 1 more Smart Citation

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Specht,

Jager,

Garbaya

et al. 2023

Preprint

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In recent times, we have unequivocally witnessed a push towards digitising the healthcare system. Topics such as remote patient monitoring (RPM), digital health, and their use to monitor neurological disease progression have gained momentum and popularity. Notwithstanding the considerable advances that have been made in adopting such technologies and using them in the context of mental health or even a few neurodegenerative disease monitoring, they have not been widely used in the context of remote management and treatment of multiple sclerosis MS. In the same vein, given that (MS) is a very individualized disease to manage, there are numerous challenges yet opportunities associated with using digital health technologies for remote MS monitoring. This paper reviews the different research work and clinical attempts performed over the last decade (both home & hospital-based monitoring) en route to using digital health for MS monitoring and management. Similarly, this systematic review discusses the main challenges and barriers to translating that research from clinics into homes and highlights the opportunities in that context. Throughout this extensive review, we shine a light on various monitoring methods that hold the potential to be measured in a home environment, including electroencephalography (EEG) and evoked potentials (e.g., motor evoked potential (MEP), somatosensory evoked potentials (SSEP), and visual evoked potential (VEP)), electromyography (EMG), inertial measurement unit (IMU), and speech analysis. Combining such digital biomarkers could pave the way for developing a more personalised treatment for MS patients, thereby stopping its progression and avoiding silent MS disability. Adopting digital health for remote monitoring and management could also chart a route ahead for a new era of personalised medicine for MS patients and potentially other brain disorder patients.

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Section: Resultsmentioning

confidence: 71%

Section: Eeg and Evoked Potentialsmentioning

confidence: 99%

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Specht,

Jager,

Garbaya

et al. 2023

Preprint

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“…Evaluaron las diferencias entre la escala de discapacidad de Kurtzke y el puntaje global de PE (PEV y PESS) antes del tratamiento, a 1,7 y 3,6 años del tratamiento, y encontraron que no hubo diferencia significativa de la escala de discapacidad en los pacientes durante el seguimiento; sin embargo, observaron una gran diferencia en el puntaje global de los PE, sobre todo del grupo con interferón β. Con este resultado concluyeron que se podría incluir el puntaje global de los PE como una variable para evaluar la efectividad de nuevos tratamientos en pacientes con EM en el futuro. 31 Iodice y cols. estudiaron 20 pacientes que fueron examinados previos al tratamiento con Fingolimod y hasta un año después, encontrando una correlación significativa entre la EDSS y el puntaje global de los PEM en los diferentes momentos del seguimiento.…”

Section: Discusión De Los Resultadosunclassified

Puntaje Global de Potenciales Evocados Multimodales Sensoriales en el Estudio de Pacientes Con Esclerosis Múltiple.

et al. 2020

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Introducción: La Esclerosis Múltiple (EM) es una enfermedad desmielinizante, inflamatoria y neurodegenerativa del sistema nervioso central, en la que se han utilizado los Potenciales Evocados Multimodales Sensoriales (PEMS) para evaluar la integridad de las vías sensoriales, pero no se han considerado sus resultados para el diagnóstico de la enfermedad. Objetivo: evaluar la relación del puntaje global de PEMS con la magnitud de la discapacidad y la presencia de lesiones en las imágenes de resonancia magnética de pacientes con EM. Métodos: se estudiaron 35 pacientes con EM forma clínica recaídaremisión en el Centro Internacional de Restauración Neurológica. Se correlacionó el puntaje global de los PEMS con la escala de discapacidad de Kurtzke y con las lesiones encontradas en la s imágenes de resonancia magnética. Resultados: se observó una correlación significativa entre el puntaje global y la escala de discapacidad (R=0.33, p< 0.05), y entre este puntaje global y el número de niveles de lesiones detectadas en las imágenes de resonancia (R= 0.42, p< 0.05). Conclusiones: La relación del puntaje global de los PEMS con las lesiones estructurales y el grado de discapacidad confirma su utilidad para el estudio de los pacientes con EM, aun cuando no forman parte de los criterios diagnósticos.

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“…Combination of VEP, BAEP and SSEP could be used as an outcome variable for determining the efficiency of a particular treatment (27). Treatment effects did not show any significance for EDSS, but there was improvement in EP score (mainly because of the significant decrease in VEP score) between different treatment groups (27).…”

Section: Evoked Potentials In Multiple Sclerosismentioning

confidence: 99%

Clinical Neurophysiology of Multiple Sclerosis

Habek

Adamec

Barun

et al. 2017

Multiple Sclerosis: Bench to Bedside

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Different neurophysiological methods such as evoked potentials (EP), testing of the autonomic nervous system (ANS) or polysomnography have the potential to detect clinically silent lesions or to confirm the existence of an association between a clinical symptom and multiple sclerosis (MS); previously undetected by MRI. Therefore, in the most recent MRI criteria for the diagnosis of MS (MAGNIMS consensus guidelines), neurophysiological confirmation of optic nerve dysfunction (slowed conduction on visual EP), support dissemination in space and, in patients without concurrent visual symptoms, dissemination in time. In this chapter we will review the existing evidence regarding the role of different neurophysiological tests (specifically the role of EPs, autonomic nervous system testing and sleep testing in MS) in the diagnosis and management of MS.

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The EP-score to assess treatment efficacy in RRMS patients: a preliminary study

Cited by 5 publications

References 25 publications

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Multiple Sclerosis in the Digital Health Age: Challenges and Opportunities - A Systematic Review

Puntaje Global de Potenciales Evocados Multimodales Sensoriales en el Estudio de Pacientes Con Esclerosis Múltiple.

Clinical Neurophysiology of Multiple Sclerosis

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