The ependyma in chronic hydrocephalus

Kiefer, M.; Eymann, Regina; Tiling, S von; Müller, Andreas; Steudel, Wolf-Ingo; Booz, K. H.

doi:10.1007/s003810050222

Cited by 39 publications

(33 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Del Bigio et al 10 , Madhavi and Jacob 13 and Kiefer et al 11 have observed alterations on the choroid epithelium such as microvilii distortion, atypical cilia, fl atten cells with and vacuoles, intracellular inclusions and enlargement of intercellular space. Some of these alterations were also seen on the present study.…”

Section: Discussionmentioning

confidence: 99%

“…The choroid plexus also present a role on the CSF clearance of drugs and substances formed on the brain tissue due to the metabolic reactions, thus presenting several active-transport systems 9,21 . The fi rst structure to suffer on the hydrocephalus process in high CSF pressure is the ependymal epithelium, with compression, distension and isolated disruption 10,11 .…”

Section: Discussionmentioning

confidence: 99%

“…Del Bigio et al 10 and Kiefer et al 11 observed reduced density of ependymal microvilli, vacuolar formation and cellular inclusions on choroid cells, and intercellular space enlargement, after experimentally induced hydrocephalus. Go et al 12 and Madhavi and Jacob 13 observed the presence of Kolmer fagocytic cells on the ependymal cells surface and on the choroid cells in hydrocephalic animals.…”

mentioning

confidence: 96%

See 2 more Smart Citations

Ultrastructural study of the lateral ventricle choroid plexus in experimental hydrocephalus in Wistar rats

Tirapelli

Lopes

Lachat

et al. 2007

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Hydrocephalus is one of the most frequent and complex neurological diseases characterized by the abnormal buildup of cerebrospinal fluid (CSF) in the ventricles of the brain, due to an altered CSF dynamics. To detect possible ultrastructural alterations of the lateral ventricles choroid plexus (responsible for the CSF production), rats seven days after birth were submitted to an intracisternal injection of 20% kaolim (hydrated aluminum silicate) for the hydrocephalus induction. Twenty-eight or 35 days after injection, injected animals and respective controls were processed for observation under a transmission electron microscopy. Alterations found: presence of concentric cell membrane fragments, larger number of primary and secondary lysossomes, vacuoles, and cytoplasmic vesicles, and an enlargement of the intercellular space and between the basolateral interdigitation of the choroid epithelium. The alterations observed are probably associated to an increase of the ventricular pressure, inducing morpho-functional effects on the choroid plexus integrity.KEY WORDS: hydrocephalus, choroid plexus, ultrastructural study, rat. Estudo ultraestrutural dos plexos corióides dos ventrículos laterais de ratos Wistar submetidos a hidrocefalia experimentalRESUMO -A hidrocefalia é uma das mais freqüentes e complexas doenças neurológicas caracterizada pelo acúmulo de líquido cefalorraquidiano (LCR) no interior dos ventrículos cerebrais e conseqüente alteração na dinâmica liquórica. Para detectar as possíveis alterações ultra-estruturais nos plexos corióides dos ventrículos laterais (responsáveis pela produção do LCR), ratos sete dias após o nascimento, foram submetidos à indução de hidrocefalia pela injeção intracisternal de caulim a 20%. Após 28 e 35 dias da injeção, estes animais e seus respectivos controles foram processados para observação em um microscópio eletrôni-co de transmissão. Alterações observadas: presença de membranas concêntricas, maior número de lisossomos primários e secundários, vacúolos e vesículas citoplasmáticas, aumento do espaço intercelular e entre as interdigitações basolaterais das células do epitélio corióideo. As alterações observadas possivelmente estão associadas ao aumento da pressão nos ventrículos, induzindo efeitos morfo-funcionais na integridade dos plexos corióides. PALAVRAS-CHAVE: hidrocefalia, plexos corióides, estudo ultra-estrutural, rato.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

See 1 more Smart Citation

Ultrastructural study of the lateral ventricle choroid plexus in experimental hydrocephalus in Wistar rats

Tirapelli

Lopes

Lachat

et al. 2007

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…It was suspected that the inheritance mode of LEW/ Jms changed over time (Jones et al, 2003). Both mutations were normally lethal at an early age, but a mild form of H-Tx rats was described (Kiefer et al, 1998). Yoon and Slaney (1972) described an autosomal recessive mutation in golden hamsters with a dome-shaped head.…”

Section: Discussionmentioning

confidence: 99%

Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Gebhardt-Henrich

Edwards

Famula

et al. 2008

Animal

View full text Add to dashboard Cite

Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified. However, when a binary score (hydrocephalus, no hydrocephalus) was used, no such major locus could be detected and results of test matings were not consistent with Mendelian inheritance. Golden hamsters with severe forms of hydrocephalus had a dorsally compressed and ventrally intact hippocampus. Implications for the behavior and well-being of affected hamsters are unknown but researchers using this strain should be aware of the likely presence of hydrocephalus.

show abstract

“…Further, several possible ways to trigger chronic hydrocephalus from the obstruction of the cerebral aqueduct by cotton injection 5 , blood 6 , bacteries 7 , kaolin-aluminum silicate 8 , and others were described. The first structure that suffers because of the increase in CSF pressure and ventricular expansion is the ependyma, followed by the white matter 9,10 . Axonal degeneration and loss of myelin are observed in chronic hydrocephalus in the corpus callosum.…”

Section: Introductionmentioning

confidence: 99%

Changes caused by hidrocephalus, induced by kaolin, in the corpus callosum of adult dogs

Cardoso¹,

Lachat²,

Lopes³

et al. 2011

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To analyze the ventricular enlargement and myelination of the corpus callosum in adult dogs after four and eight weeks of kaolin-induction of hydrocephalus. METHODS: 36 dogs were randomly divided into 3 groups: 1 -without hydrocephalus, 2 -kaolin-induction of hydrocephalus until the fourth week, and 3 -kaolin-induction of hydrocephalus until the eighth week. Ventricular ratios and volumes were calculated using magnetic resonance images, and myelination of the corpus callosum were histologically evaluated using solocromo-cianin stain. RESULTS: Radiological hydrocephalus was observed in 93.75% and overall mortality was 38.4%. Ventricular volumes and ratios were higher in groups 2 and 3 compared to group 1 and similar when measures in the fourth and eighth weeks were compared in the group 3. Indices of luminescence in the knee and in the splenium of the corpus callosum were higher in group 2 than in group 1 indicating that there was loss of myelin in group 2, and similar in groups 1 and 3, showing a tendency to remyelination after 8 weeks. CONCLUSION: The corpus callosum of dogs with kaolin-induced hydrocephalus responds with demyelination of the knee and splenium by the fourth week with a tendency to remyelination by the eighth week. Key words: Hydrocephalus. Corpus Callosum. Myelin Sheath. Dogs. RESUMO OBJETIVO:Analisar a dilatação ventricular e a mielinização do corpo caloso em cães adultos após quatro e oito semanas da indução de hidrocefalia por caulin. MÉTODOS: 36 cães foram aleatoriamente divididos em 3 grupos: 1-sem hidrocefalia, 2-quatro semanas de hidrocefalia induzida por caulin, 3-oito semanas de hidrocefalia induzida por caulin. As razões e volumes ventriculares foram calculados utilizando imagens de ressonância magnética, e, a mielinização do corpo caloso por estudo histológico (coloração com solocromo-cianina). RESULTADOS: Hidrocefalia foi observada radiologicamente em 93,75% e a mortalidade global foi de 38,4%. Os volumes e as razões ventriculares foram maiores nos grupos 2 e 3 em relação ao grupo 1 e semelhantes nas quarta e oitava semanas no grupo 3. Índices de luminescência no joelho e no esplênio do corpo caloso foram maiores no grupo 2 em relação ao grupo 1, indicando que houve perda de mielina no grupo 2, e semelhantes nos grupos 1 e 3, mostrando uma tendência à remielinização em torno de 8 semanas. CONCLUSÃO: O corpo caloso de cães com hidrocefalia induzida por caulin responde com desmielinização no joelho e esplênio em torno de quatro semanas com tendência à remielinização em torno da oitava semana. Descritores: Hidrocefalia. Corpo Caloso. Bainha de Mielina. Cães. Changes caused by hidrocephalus, induced by kaolin, in the corpus callosum of adult dogsActa Cirúrgica Brasileira -Vol. 26 (Suppl. 2) 2011 -9

show abstract

The ependyma in chronic hydrocephalus

Cited by 39 publications

References 14 publications

Ultrastructural study of the lateral ventricle choroid plexus in experimental hydrocephalus in Wistar rats

Ultrastructural study of the lateral ventricle choroid plexus in experimental hydrocephalus in Wistar rats

Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Changes caused by hidrocephalus, induced by kaolin, in the corpus callosum of adult dogs

Contact Info

Product

Resources

About