The epidemiologic status of gynecologic cancer in Thailand

Wilailak, Sarikapan; Lertchaipattanakul, Nuttapong

doi:10.3802/jgo.2016.27.e65

Cited by 23 publications

(21 citation statements)

References 6 publications

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“…Endometrial cancer is the 9th most common female cancer in Thailand (Wilailak et al, 2016). Most endometrial cancer cases were diagnosed at stage I due to vaginal bleeding symptoms which brought patients to see their physicians.…”

Section: Discussionmentioning

confidence: 99%

“…It is a hormone dependent cancer with either unopposed estrogen condition or exogenous stimulation from tamoxifen (Dowdy et al, 2019).Endometrial cancer is the 6 th most commonly occurring cancer in women (Bray et al, 2018). In Thailand, endometrial cancer is the 9th most common form of female cancer with age standardized incidence rate of 4.3/100,000 women per year (Wilailak et al, 2016).…”

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confidence: 99%

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Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital

Sivapornpan

Suwannarurk

Jaisin

et al. 2020

Asian Pac J Cancer Prev

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Endometrial cancer is a gynecologic malignancy that occurs in women most commonly in their sixth and seventh decade. Most cases had underlying diseases i.e., diabetes mellitus (DM), hypertension (HT) and dyslipidemia (DLP). It is a hormone dependent cancer with either unopposed estrogen condition or exogenous stimulation from tamoxifen (Dowdy et al., 2019).Endometrial cancer is the 6 th most commonly occurring cancer in women (Bray et al., 2018). In Thailand, endometrial cancer is the 9th most common form of female cancer with age standardized incidence rate of 4.3/100,000 women per year (Wilailak et al., 2016). AbstractBackground: This study aimed to survey quality of life (QoL) in endometrial cancer survivors between surgery with adjuvant therapy (radiation with or without chemotherapy) and surgery alone in Thammasat University Hospital, Thailand. Materials and Methods: This cross-sectional study was conducted at the Gynecologic Oncology clinic, Thammasat University hospital, Thailand between March 2011 and May 2019. Participants were endometrial cancer cases who underwent surgical staging with or without adjuvant treatment (study) and healthy women who came to gynecologic department for annual cervical screening (control). Assessment of QoL was investigated via the structural questionnaire designed by the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 (Thai version). Results: During the period of the study, 94 participants who were diagnosed with endometrial cancer and underwent surgical staging were enrolled. There were 51, 43 and 51 cases in group A (surgery with adjuvant therapy), group B (surgery only) and group C (control), respectively. Control cases were participants who had comparable demographic characteristics and underwent gynecological checkup during the period of study. In part of physical functioning, group B had statistically better scores than group A. Participant in group B and C reported significantly better QoL in part of social functioning than group A. Symptom severity; appetite loss and constipation in group B was statistically less than in group A. Constipation problems in group A and C were comparable. Participants in group C had worse global health status than group A/B. Conclusion: Adjuvant treatment with either radiation or chemotherapy had negative impacts on QoL in endometrial cancer survivors. It impacted physical health, social function, appetite loss, and constipation. All endometrial cancer survivors had global health scores better than healthy peers. Thoroughly counseling to endometrial cancer survivors remains an important tool for increasing awareness of treatment complications and lowering psychological emotional stress.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital

Sivapornpan

Suwannarurk

Jaisin

et al. 2020

Asian Pac J Cancer Prev

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“…In women who test negative on VIA or cytology, the screening interval for repeat screening should be every 3-5 years (WHO, 2013). In Thailand, the Ministry of Public Health has recommended to start cervical cancer screening with Pap cytology in women aged 30 years at 5 years interval until the age of 60 years (Wilailak and Lertchaipattanakul, 2016). However, there is a proportion of women who develop HSIL before the age of 30 years.…”

Section: Department Ofmentioning

confidence: 99%

Factors Associated with Development of High-Grade Squamous Intraepithelial Lesions of the Uterine Cervix in Women Younger than 30 Years

Wudtisan

Tantipalakorn

Charoenkwan

et al. 2019

Asian Pac J Cancer Prev

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Objective: To determine the factors associated with the increased risk of developing high-grade squamous intraepithelial lesions (HSIL) of the uterine cervix in women younger than 30 years compared with those aged ≥ 30 years who also had HSIL. Methods: Patients with HSIL who underwent loop electrosurgical excision procedure (LEEP) between January 2006 and July 2017 at Chiang Mai University Hospital were retrospectively reviewed. We analyzed the factors associated with the development of HSIL by comparing two age groups between women aged < 30 years and those aged ≥ 30 years. The factors analyzed included the well-recognized risk factors for cervical cancer, i.e. age at sexual debut, number of sexual partners, use of oral contraceptive (OC) pills, smoking history, sexually transmitted diseases and HIV status. Univariate and multivariate logistic regressions were used to assess factors associated with the increased risk of developing HSIL in women younger than 30 years compared with those aged ≥ 30 years. Results: During the study period, there were 345 patients with HSIL, 30 were < 30 years (case group) and 315 aged ≥ 30 years (control group). By multivariate analyses , early sexual debut(OR, 2.86; 95% CI, 1.01-8.13; P=0.047), multiple sexual partners (OR, 2.94; 95% CI, 1.23-7.02; P=0.015), history of genital warts (OR, 20.46; 95% CI, 2.27-183.72; P=0.007) and history of smoking (OR, 2.95; 95% CI, 1.10-7.93; P=0.032) were significantly associated with the development of HSIL in women younger than 30 years when compared with those aged ≥ 30 years. The OC use, HIV status and underlying diseases were not significantly different in both groups. Conclusion: Early age at sexual debut, multiple sexual partners, history of genital warts and smoking are significant risk factors for developing HSIL in women younger than 30 years. Cervical cancer screening should be considered in young women with such factors.

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“…Epithelial ovarian cancer (EOC) is the 6th most common cancer among Thai females with the age standardized rate of 6.0 per 100,000 females [1,2]. The principal treatment for epithelial ovarian cancer (EOC), fallopian tube and peritoneal carcinoma is surgical resection of tumors along with uterus and retroperitoneal lymph node.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube and Primary Peritoneal Cancer: Thai Multi-institutional Study

Lertkhachonsuk

Suprasert

Manchana

et al. 2020

Preprint

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Background:Ovarian, fallopian tube or primary peritoneal cancer patientswithBRCA gene mutation have enhanced sensitivity to platinum-based regimens and PARP inhibitors. However, the knowledgeregardingBRCA mutation in Thai patients are limited. This study is to identify the prevalence and characteristics of somatic and germline BRCA1&2mutations in Thai patients with these cancers.Methods::The paraffin blocks of tumorsthat had histology of high grade serous or high grade endometrioid, or clear cell carcinomawhich obtained between June 2016 and December 2017 were processed to evaluate BRCA mutation using next-generation sequencingsystem. Blood or normal tissue paraffin blocks of positive patients were further tested for germline BRCA mutation. Results:Tissue paraffin blocks of 178 patients were collected. Only 139 patients whose paraffin-blocks could be processed. PositiveBRCAmutation was identified in 24 cases (17.3%): BRCA1in 13 cases, BRCA2 in 10 cases, and BRCA1&2in another. Germline mutation study in blood or normal tissue in 23positive patients revealed BRCA mutation in 14 cases: BRCA1(8 cases)and BRCA2 (6 cases). Overall, the prevalence of somatic and germline mutation were 6.5% (9 in 138 patients) and 8.7% (14 in 138 patients) respectively. The most common histology associated withBRCA mutation was high grade serous cancer (27.3%). No significant differencebetween,stage, outcome, platinum status and survival outcome in patients with or without BRCA mutation.Conclusion: BRCA mutation in Thai ovarian cancer patients was demonstrated in less than 10%. Higher rate of mutation was found in high grade serous cancer.

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The epidemiologic status of gynecologic cancer in Thailand

Cited by 23 publications

References 6 publications

Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital

Comparative Study in Quality of Life between Thai Endometrial Cancer Survivors and Healthy Women in Thammasat University Hospital

Factors Associated with Development of High-Grade Squamous Intraepithelial Lesions of the Uterine Cervix in Women Younger than 30 Years

Prevalence of Tissue BRCA Gene Mutation in Ovarian, Fallopian Tube and Primary Peritoneal Cancer: Thai Multi-institutional Study

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