The epidemiological aspects of congenital heart disease in central and southern district of Iran

Amel-Shahbaz, Sara; Behjati-Ardakani, Mostafa; Namayandeh, Seyedeh Mahdieh; Vafaeenasab, Mohammadreza; Andishmand, Abbas; Moghimi, Samane; Negahdary, Masoud; Sarebanhassanabadi, Mohammadtaghi

doi:10.4103/2277-9175.145732

Cited by 14 publications

(7 citation statements)

References 18 publications

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“…In the current study, ASD constitutes 9.8% of congenital anomalies, which is comparable to the results of other studies. The ratio of female to male patients in this study was 1:5, which is lower than that in some studies ( 2 ) but in closer agreement with other reports ( 1 , 6 ).…”

Section: Discussionsupporting

confidence: 90%

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The Clinical Course of Patients With Atrial Septal Defects

et al. 2016

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BackgroundAtrial septal defect (ASD) is a common congenital heart disease.ObjectivesThe aim of this study was to assess the clinical course of ASD, as well as its frequency of spontaneous closure and regression of diameter.MethodsIn a study conducted from 2000 to 2011, 192 consecutive patients with an isolated ASD were followed up regularly with periodic echocardiographic evaluations according to a standardized protocol. The study was conducted in two series of patients: infants and children and adults. Infants were classified into three groups based on ASD diameter: small (≤ 5 mm), medium (6 - 9 mm), and large (> 9 mm). In the same manner, the ASD size in children and adults was categorized into three groups: small (≤ 10), medium (10 - 20 mm), and large (> 20 mm).ResultsThe patients consisted of 76 (39.6%) males and 116 (60.4%) females. The mean age of patients at diagnosis was 16.12 ± 15.66 years (range 1 week - 75 years). The mean follow-up duration was 70 ± 9 months (range: 25 - 119 months). The most prevalent age group was adult patients (> 20 years), and most ASDs were of medium size (1 - 2 cm). The most common complication was mild pulmonary hypertension (31 cases, 16.2%), and Eisenmenger phenomenon was the rarest complication (2 cases, 1%). Overall spontaneous closure of ASD occurred in 42 (21.9%) cases. Spontaneous closure in cases with small defects occurred in 18 of 22 (81%) infants and 24 of 81 children > 1 years of age. Regression of ASD size occurred in 2 (9.5%) infants and 3 (3.7%) children. No spontaneous closure was observed in cases with a defect size > 10 mm, and no spontaneous occlusion was detected in adolescents or adults. Seventy-two percent (n = 139) of patients needed surgical repair or transcatheter closure of the ASD.ConclusionsIt is concluded that atrial septal defects < 6 mm typically close spontaneously, and ASDs measuring 6 - 9 mm may regress in infants and children. An ASD > 1 cm has little chance of spontaneous closure and may need surgical or device closure. ASD diameter and age at diagnosis are the most important predictors of spontaneous closure and the need for possible surgical or device closure.

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Section: Discussionsupporting

confidence: 90%

“…ASD is more common in females than in males ( 1 , 2 ). Several studies have reported spontaneous closure of ASD.…”

Section: Introductionmentioning

confidence: 99%

The Clinical Course of Patients With Atrial Septal Defects

et al. 2016

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“…20,26 On the other hand, when considering gender, our results contradict some studies showing female preponderance in congenital heart defects such as VSD, PDA, and ASD. For example, Amel et al, 27 who studied 3714 newborns from the south of Iran, found that a higher proportion of female infants suffered from VSD, PDA, ASD, and TOF. Another article showed a slight preponderance of females in the prevalence of CHD (VSD and PDA) on 2067 patients conducted by Ishikawa et al in China.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran

Parvar

Ghaderpanah

Naghshzan

2023

Health Science Reports

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Introduction Congenital heart disease (CHD), the lethal congenital anomaly in newborns, is multifactorial, with environmental and genetic factors contributing to its occurrence. Although some studies on the prevalence of CHD have been conducted throughout the country, this large‐scale study aims to provide information on the prevalence of various types of CHDs in newborns according to the echocardiography findings. Patients and Methods Over 3 years, 8145 neonates with suspected CHD who underwent echocardiography by a trained pediatric cardiologist were included in this multicenter, cross‐sectional observational study. CHD was categorized into two major groups; cyanotic and acyanotic heart disease. The SPSS version 22 software was used to analyze the data with a significance level set at 0.05. Results Of 8145 neonates who were referred to our centers with CHD symptoms, 6307 were indicated for echocardiography. The mean age of the studied population was 8.5 ± 9.3 days and the male‐to‐female ratio was 2.6, especially in the arterial septal defect (ASD), ventricular septal defect (VSD), and patent ductus arteriosus (PDA) groups. 77.2% of patients had acyanotic heart disease (100 in 1000 neonates) with ASD as the most common one and 9% were diagnosed with cyanotic heart disease (11 in 1000 neonates) with transposition of the great arteries as the most common form and the aortopulmonary window was the rarest form. Conclusion This large prospective, multicenter screening study reported arterial septal defect (85%) and patents with ductus arteriosus (32%) as the most frequent type of CHD. Moreover, the prevalence of male patients was significantly higher. This information would be helpful for health policy makers, stakeholders, and general practitioners in regions where there are no trained pediatric cardiologist fellowships and limited access to echocardiography devices for better management of CHD.

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“…The difference in gender in this study were different from the clinical impression that WS had no sex difference. SVAS and VSD incidence difference in gender were used reported (Amel‐Shahbaz et al, 2014; Sadler et al, 2001). Female also showed a comparative advantage in other heart diseases such as myocardial injury and prognosis of some heart diseases (Kanwar & Stehlik, 2020).…”

Section: Discussionmentioning

confidence: 99%

Clinical phenotypes study of 231 children with Williams syndrome in China: A single‐center retrospective study

Chen

Yao

et al. 2022

Molec Gen & Gen Med

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Background: Williams syndrome (WS) is a multisystem neurodevelopmental disorder caused by microdeletions in 7q11.23. This study aims to characterize the clinical phenotypes of Chinese children with WS to help for the early diagnosis and intervention of this disease. Methods: 231 children diagnosed with WS were retrospectively recruited to the study. Clinical data were analyzed to obtain the incidence of different clinical phenotypes. The occurrence of phenotypes and the influence of gender and age on the incidence of different phenotypes were analyzed.Results: All WS exhibited facial dysmorphism (100.0%). The majority had neurodevelopmental disorder (91.8%), hoarseness (87.4%) and cardiovascular anomalies (85.7%). The incidence of short stature (46.9%), inguinal hernia (47.2%), hypercalciuria (29.10%), hypercalcemia (9.1%), subclinical hypothyroidism (26.4%) and hypothyroidism (7.4%) were relatively higher. Gender differences were found in supravalvular aortic stenosis (SVAS, p < .001), ventricular septal defect (VSD, p < .05), inguinal hernia (p < .001), superior pulmonary stenosis (SVPS, p < .05) and neurodevelopmental disorder (p < .05). The incidence of neurodevelopmental disorder in WS increased with age (p < .05

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The epidemiological aspects of congenital heart disease in central and southern district of Iran

Cited by 14 publications

References 18 publications

The Clinical Course of Patients With Atrial Septal Defects

The Clinical Course of Patients With Atrial Septal Defects

Prevalence of congenital heart disease according to the echocardiography findings in 8145 neonates, multicenter study in southern Iran

Clinical phenotypes study of 231 children with Williams syndrome in China: A single‐center retrospective study

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