The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014

Sun, Jiufeng; Wu, De; Zhou, Huiqiong; Zhang, Huan; Guan, Dawei; He, Xiang; Cai, Shumin; Ke, Changwen; Lin, Junfen

doi:10.1016/j.jinf.2015.10.007

Cited by 42 publications

(45 citation statements)

References 29 publications

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“…A phylogenetic analysis suggested that the dengue virus isolated in Guangzhou, 2014 was most similar to the isolates in Singapore, Malaysia, Indonesia and Thailand [46, 47]. The importation index, which incorporates both the incidence in country of origin and the travel volume between the target city and the country of origin [48, 49], also shows that Singapore, Thailand and Malaysia had the highest importation indices in 2013, and the order changed to Malaysia, Singapore and Thailand in 2014.…”

Section: Discussionmentioning

confidence: 99%

The interplay of climate, intervention and imported cases as determinants of the 2014 dengue outbreak in Guangzhou

et al. 2017

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Dengue is a fast spreading mosquito-borne disease that affects more than half of the population worldwide. An unprecedented outbreak happened in Guangzhou, China in 2014, which contributed 52 percent of all dengue cases that occurred in mainland China between 1990 and 2015. Our previous analysis, based on a deterministic model, concluded that the early timing of the first imported case that triggered local transmission and the excessive rainfall thereafter were the most important determinants of the large final epidemic size in 2014. However, the deterministic model did not allow us to explore the driving force of the early local transmission. Here, we expand the model to include stochastic elements and calculate the successful invasion rate of cases that entered Guangzhou at different times under different climate and intervention scenarios. The conclusion is that the higher number of imported cases in May and June was responsible for the early outbreak instead of climate. Although the excessive rainfall in 2014 did increase the success rate, this effect was offset by the low initial water level caused by interventions in late 2013. The success rate is strongly dependent on mosquito abundance during the recovery period of the imported case, since the first step of a successful invasion is infecting at least one local mosquito. The average final epidemic size of successful invasion decreases exponentially with introduction time, which means if an imported case in early summer initiates the infection process, the final number infected can be extremely large. Therefore, dengue outbreaks occurring in Thailand, Singapore, Malaysia and Vietnam in early summer merit greater attention, since the travel volumes between Guangzhou and these countries are large. As the climate changes, destroying mosquito breeding sites in Guangzhou can mitigate the detrimental effects of the probable increase in rainfall in spring and summer.

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Section: Discussionmentioning

confidence: 99%

The interplay of climate, intervention and imported cases as determinants of the 2014 dengue outbreak in Guangzhou

et al. 2017

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“…In China, the third historically largest dengue hemorrhagic fever (DHF) outbreak spread throughout Guangdong province with 6024 confirmed DHF cases resulting in six deaths (Sun et al, 2016), as well as reported cases among 26 Chinese provinces (Lai et al, 2015) in 2014. The outbreak of DHF raised the increasing concern on DENV infection nationwide.…”

Section: Dear Sirmentioning

confidence: 99%

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Dear Sir,Dengue virus (DENV) has been listed on a catalogue from the American Association of Blood Banks (AABB) as transfusion transmissible infectious (TTIs) (Stramer et al, 2009). Routine screening for DENV RNA with nucleic acid testing (NAT) on donors' samples has been suggested to reduce the transfusion-transmitted risk of DENV in several countries and regions with high epidemic, such as Honduras (Linnen et al, 2008) and Brazil (Dias et al, 2012).In China, the third historically largest dengue hemorrhagic fever (DHF) outbreak spread throughout Guangdong province with 6024 confirmed DHF cases resulting in six deaths (Sun et al, 2016), as well as reported cases among 26 Chinese provinces (Lai et al, 2015) in 2014. The outbreak of DHF raised the increasing concern on DENV infection nationwide.

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mentioning

confidence: 99%

Sero‐prevalence and viremia status of dengue virus among asymptomatic blood donors post epidemic outbreak in Chinese Guangzhou in 2015

Zeng

Liao

Gao

et al. 2018

Transfusion Medicine

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Dear Sir,Dengue virus (DENV) has been listed on a catalogue from the American Association of Blood Banks (AABB) as transfusion transmissible infectious (TTIs) (Stramer et al., 2009). Routine screening for DENV RNA with nucleic acid testing (NAT) on donors' samples has been suggested to reduce the transfusion-transmitted risk of DENV in several countries and regions with high epidemic, such as Honduras (Linnen et al., 2008) and Brazil (Dias et al., 2012).In China, the third historically largest dengue hemorrhagic fever (DHF) outbreak spread throughout Guangdong province with 6024 confirmed DHF cases resulting in six deaths (Sun et al., 2016), as well as reported cases among 26 Chinese provinces (Lai et al., 2015) in 2014. The outbreak of DHF raised the increasing concern on DENV infection nationwide. However, the data on the DENV sero-prevalence and viremia status among blood donors were rare. A pilot investigation among asymptomatic donors in Guangzhou city (Guangdong province) during the epidemic outbreak (2014) reported that the anti-DENV IgM prevalence rate was 2·4% (n = 3000) (Rong et al., 2015), indicating a potential transfusion-transmitted risk. The sero-prevalence and viremia rate of DENV in blood donors from Guangzhou post the epidemic outbreak should be investigated.From April to October 2015, 1164 whole blood and apheresis donors who passed the routine pre-donation screening process were recruited during the routine donation process from the Guangzhou blood centre. Donor samples from the first 3 weeks of each month during the study period (n = 819) were selected and tested both for anti-DENV IgG and IgM using capture ELISA kits from Panbio (Brisbane, Australia), in which 34 were positive for IgG and three positive for IgM. The DENV seropositive rates were: IgG, 4·2% (34/819, 95%CI: 2·8-5·6%) and IgM, 0·4% (3/819, 95%CI: 0-0·8%). The demographic characteristics of 36 seropositive donors (one donor positive both for IgG and IgM) were similar to that of all the participated donors and no significant difference was found by gender, ethnicity and age. The DENV IgG rate was similar to the rate from donor samples collected in 2014 in the same area (3·4%, 51/1500) (Liao et al., 2017),

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“…Among them, 641 DENV infections were confirmed by laboratory testing (436 RNA positive and 205 IgM positive) [76]. The following year, the third historically largest DHF outbreak spread throughout Guangdong province (20 of 21 cities with reported cases) with 45 236 febrile cases (6024 DENV infections confirmed) resulting in 6 deaths [77]. Partly in response to the outbreaks in 2013 and 2014, the Chinese Center for Disease Control and Prevention (CDC) amended the guidelines for DHF prevention and control to strengthen the implementation of mosquito control [78].…”

Section: Dengue Viruses (Denv)mentioning

confidence: 99%

The Impact of Emerging Infectious Diseases on Chinese Blood Safety

Wang

Chen

et al. 2017

Transfusion Medicine Reviews

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Emerging infectious diseases (EIDs) have always been one of the major threats to public health. Although the implementation of mandatory testing for 4 classical transfusion-transmitted infectious-human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis-has reduced the transfusion risk of these pathogens, the potential threat of various EID agents and their constantly evolving variants to blood safety in China is not fully understood. This review presents 9 representative EID agents that are autochthonous and epidemic nationally or regionally in China. The epidemiologic status and distribution of these EID agents among donors and/or healthy populations are summarized. The potential risks of these EID agents to blood safety are discussed. The review also explores strategies to strengthen hemovigilance systems and studies to further evaluate the impact of EID agents on blood safety.

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The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014

Cited by 42 publications

References 29 publications

The interplay of climate, intervention and imported cases as determinants of the 2014 dengue outbreak in Guangzhou

The interplay of climate, intervention and imported cases as determinants of the 2014 dengue outbreak in Guangzhou

Sero‐prevalence and viremia status of dengue virus among asymptomatic blood donors post epidemic outbreak in Chinese Guangzhou in 2015

The Impact of Emerging Infectious Diseases on Chinese Blood Safety

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