The Epidemiological, Clinical, Biological and Morphological Characteristics of Primitive Liver Cancers in Bangui

Abstract

Objective: To describe the epidemiological, clinical, biological and morphological aspects of primary liver cancer (PLC). Patients and Methods: We conducted a 38-month cross-sectional study in the Department of hepatogastroenterology and Internal Medicine "Amitié Sino-Centrafraine" University Hospital Center in Bangui. Included in the study were all patients with a diagnosis of PLC. The PLC's diagnostic arguments were the large tumor liver associated or not with the elevation of alpha-fetoprotein, the heteronodular liver hypervascularized on abdominal ultrasound. Data analysis was done using Epi Info 3.5.1 software. Results: We collected 115 cases of CPF among 2410 hospitalized patients (4.7%). There were 86 men and 29 women (sex ratio: 2.9). The average age was 50 years old. The main risk factors were alcohol consumption (72.2%) and chronic hepatitis B infection (67.4%). Frequent clinical signs were pain in the right hypochondrium and/or epigastric (93.86%), large tumor liver under examination (91.3%), weight loss (74.78%). The serum alpha-fetoprotein concentration was ≥ 400 ng/ml in 73% of the cases. The abdominal ultrasound found a heteronodular liver in all patients. The nodules were multiple hyperechoic in 66.1% of the cases. According to the Child-Pugh classification, the patients were classified as B (49.

Hepatitis B Virus in Cirrhosis and Primary Livers Cancers

“…The frequency of HBV during cirrhosis and/or HCC in our study is lower than that reported by authors in Ndjamena (65.5%) [14] and Pointe Noire in Congo (63%) [27]. Previous studies in Bangui reported a prevalence of 62.5% [24] for cirrhosis and 67.4% [25] for HCC. Other authors have observed a prevalence of 54.50% during cirrhosis [28] and 41% in patients with HCC [29].…”

“…In contrast, patients with HCC in our study had an average age of 48 years. This is lower than the 50 years reported in Bangui [25].…”

“…However, in Chad, HBV seroprevalence was 67.3% in patients with cirrhosis and 56.3% in patients with HCC [14]. In studies in Bangui, HBV was the cause of cirrhosis in 62.5% [24] and of HCC in 67.4% [25]. The aim of this study is to assess the seroprevalence of HBsAg in cirrhosis and HCC in order to help improve patient management.…”

Contribution du Scanner à L’exploration des Pathologies Abdominales à Bangui

“…La tranche d'âge de 60 -69 ans (27,84%) était proche de ceux obtenus par Biwolé au Cameroun, qui avait dans sa série une moyenne d'âge de 50,22 ± 14 ans et une tranche d'âge majoritaire de 61 -70 ans (28,04%) (Biwole et al, 2020). En 2020 en Centrafrique, Police avait trouvé un âge moyen de 50 ± 16 ans (Police et al, 2020). En 2016 en Guinée, Diallo avait retrouvé une population moins jeune que la nôtre, avec un âge moyen de 60,29 ans, et les extrêmes de 31 et 90 ans (Diallo et al,2016).…”

“…2015) avait trouvé dans sa série, en majorité les péritonites généralisées (41,01%).Au Benin(Gbessi et al, 2015) avait observé que les appendicites dominaient sa population d'étude avec 31,95%. Dans notre série les crcinomes hépatocellulaires représentaient (23,07%), cette constatation était inférieure à celle observée par(Police et al, 2020). Le CHC est une prolifération anarchique et autonome des cellules du foie avec anomalie du Chromosome.…”