The Epidemiological Relevance of Family Study in Chagas Disease

Zulantay, Inés; Apt, Werner; Ramos, Daniel; Godoy, Lorena; Valencia, Claudio; Molina, M P; Sepúlveda, Eduardo; Thieme, Patricio; Martínez, Gabriela; Corral, Gabriela

doi:10.1371/journal.pntd.0001959

Cited by 21 publications

(13 citation statements)

References 11 publications

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“…There is no programme to screen pregnant women at risk, their children and the rest of the family in case of positive results as shown effective elsewhere (Zulantay et al . ). No national recommendation pertains to testing blood and organ donors or persons with current or foreseen immunosuppression at risk of reactivation of the infection.…”

Section: Methodsmentioning

confidence: 99%

Chagas disease in Australia and New Zealand: risks and needs for public health interventions

Jackson

Pinto

Pett

2013

Tropical Med Int Health

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Abstractobjective International migration has changed the global distribution of Chagas disease, with the emerging importance of non-endemic regions. We aimed at better documenting the Australia and New Zealand risk of Chagas disease and needs for interventions.methods We reviewed Chagas disease-related evidences, policies and practices in Australia and New Zealand and calculated the estimated prevalence.

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Section: Methodsmentioning

confidence: 99%

Chagas disease in Australia and New Zealand: risks and needs for public health interventions

Jackson

Pinto

Pett

2013

Tropical Med Int Health

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“…The mother-to-child T. cruzi transmission rate in different endemic areas is variable: 10% in Paraguay [3], 3.4–8.6% in Bolivia [4]–[6], 2.3% in Chile [7], 1.4% in Brazil [8], and 7–11% in Argentina [9]–[11]. Sometimes these vertical transmission rates are underestimated, as a high percentage of children do not complete the necessary one-year follow-up to confirm T. cruzi infection [3], [9], [12]–[14].…”

Section: Introductionmentioning

confidence: 99%

How to Improve the Early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Children

et al. 2013

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BackgroundAccording to the Chagas congenital transmission guides, the diagnosis of infants, born to Trypanosoma cruzi infected mothers, relies on the detection of parasites by INP micromethod, and/or the persistence of T. cruzi specific antibody titers at 10–12 months of age.Methodology and Principal FindingsParasitemia levels were quantified by PCR in T. cruzi-infected children, grouped according to the results of one-year follow-up diagnosis: A) Neonates that were diagnosed in the first month after delivery by microscopic blood examination (INP micromethod) (n = 19) had a median parasitemia of 1,700 Pe/mL (equivalent amounts of parasite DNA per mL); B) Infants that required a second parasitological diagnosis at six months of age (n = 10) showed a median parasitemia of around 20 Pe/mL and 500 Pe/mL at 1 and 6 months old, respectively, and C) babies with undetectable parasitemia by three blood microscopic observations but diagnosed by specific anti - T. cruzi serology at around 1 year old, (n = 22), exhibited a parasitemia of around 5 Pe/mL, 800 Pe/mL and 20 Pe/mL 1, 6 and 12 month after delivery, respectively. T. cruzi parasites were isolated by hemoculture from 19 congenitally infected children, 18 of which were genotypified as DTU TcV, (former lineage TcIId) and only one as TcI.SignificanceThis report is the first to quantify parasitemia levels in more than 50 children congenitally infected with T. cruzi, at three different diagnostic controls during one-year follow-up after delivery. Our results show that the parasite burden in some children (22 out of 51) is below the detection limit of the INP micromethod. As the current trypanocidal treatment proved to be very effective to cure T. cruzi - infected children, more sensitive parasitological methods should be developed to assure an early T. cruzi congenital diagnosis.

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“…As an example, this is evidenced in the confirmation of T. cruzi infection of 147 pregnancy women for 4.280 inquired by conventional serology [12]. However, it is estimate that in our country there are 145.000 infected people, a figure that could increase is considered family study around index cases [13]. In relation to the education experience in the area of the study, highlights some actions developed in adults with chronic Chagas disease [14] and pregnant women infected with T. cruzi [15].…”

Section: Discussionmentioning

confidence: 92%

Chagas Disease: A Global Neglected Disease that Require Continuous Medical Education

Apt¹,

Galafé²,

Zulantay

et al. 2013

J Community Med Health Educ

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The Epidemiological Relevance of Family Study in Chagas Disease

Cited by 21 publications

References 11 publications

Chagas disease in Australia and New Zealand: risks and needs for public health interventions

Chagas disease in Australia and New Zealand: risks and needs for public health interventions

How to Improve the Early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Children

Chagas Disease: A Global Neglected Disease that Require Continuous Medical Education

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