The epidemiology and consequences of Schistosoma mansoni infection in West Nile, Uganda II. Hospital investigation of a sample from the Panyagoro community

Morbidity from Schistosoma Mansoni in Relation to Intensity of Infection in a Community-Based Study

“…Similar results have been reported by other investigators. [8][9][10][11][12][13] Constipation/flatulence was found to be associated with S. mansoni infection in the present study, though Gremillion 8 did not observe this in infected Saudi Arabian recruits in the U.S.…”

“…There have been many cross-sectional studies conducted in other communities that examine the morbidity of S. mansoni infection in relation to the intensity of infection. These include reports from Brazil, 9,10 Uganda, 11 Kenya, 12,13 Puerto Rico, 14 Ethiopia, 15 Egypt, 16 Zambia, 17 and Zaire. 18 Similar studies have been conducted on school children in St. Lucia, 19 Ethiopia, 20 and in Botswana.…”

“…The morbidity studies were conducted using the methods of Kloetzel, 9 Ongom and Bradley, 11 Cline et al, 14 and Smith et al 13 Medical history and physical examination were conducted in a "blind design," i.e., without prior knowledge of intensity of infection. All subjects were interviewed as to the occurrence of the following reported symptoms (during the last two weeks before the interview): abdominal pain, fatigue, blood in stool, diarrhea, constipation/flatulence, nausea, and poor appetite.…”

Evidence for a long-term effect of a single dose of praziquantel on Schistosoma mansoni-induced hepatosplenic lesions in northern Uganda.

“…[12][13][14] Indeed, during our multicenter study on the geographical variation of S. mansoni infection, covering 5 African countries (Mali, Senegal, Tanzania, and Madagascar in additon to Uganda), this area had the highest morbidity (Frenzel K and others, unpublished data). In this context, the presented results show reversibility of PT after treatment with praziquantel in a high-morbidity area of Uganda.…”

“…[11][12][13][14] In October 1991, 1,363 persons (exclusive of the patients who had received previous treatment) were initially admitted to the study. These included 388 pupils from primary schools, 412 fishermen, 59 members of the local administration, and 504 villagers, who spontaneously presented at their own initiative through the local medical assistant.…”