The epidemiology and consequences of Schistosoma mansoni infection in West Nile, Uganda

Ongom, V. L.; Bradley, David J.

doi:10.1016/0035-9203(72)90118-6

Cited by 89 publications

(23 citation statements)

References 13 publications

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“…Any of these methods or in combination as applicable were used to detect the morbidity and pathology due to S. mansoni . By these methods it was difficult to accurately assess the degree of pathology in these organs (Nelson 1958a or 1958b//; Ongom et al 1972, 1997). Beside, the invasive needle biopsy of these organs in inexperience hands was risky and sometimes fatal.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Schistosoma mansoni morbidity one year after praiquantel treatment in rhino camp and Obongi in West Nile, Uganda

Odongo-Aginya

Lakwo²,

Doehring

2010

African Journal of Infectious Diseases

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An evaluation study on reversibility of Schistosoma mansoni induced periportal fibrosis (PF) morbidity following treatment with praziquantel, 40mg/kg body weight after one year, was carried out in Rhino Camp and Obongi all are West Nile districts in northern Uganda. To assess the reversibility of Schistosoma (S) mansoni induced PFs morbidity following treatment with praziquantel, 40mg/kg body weight after one year. The design was a Prospective cohorts study; and the setting was a busy canoe landing sites along Albert Nile in Schistosoma (S) mansoni hyperendemic areas of Rhino Camp and Obongi fishing village were selected for the study. Previously in 2005, 1562 people including fishermen and women, school pupils, teachers, and civil servants were studied in both fishing villages for S. mansoni using Kato/Katz stool smear method.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Schistosoma mansoni morbidity one year after praiquantel treatment in rhino camp and Obongi in West Nile, Uganda

Odongo-Aginya

Lakwo²,

Doehring

2010

African Journal of Infectious Diseases

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“…Repeated treatment with PZQ within short intervals was also found to have no effect on the re-infection period in children in their first decade of life (Correa-Oliveira, et al, 2000). Nevertheless, the cure proportion of PZQ is greater if the treatment is repeated within a short period but the cost of the treatment remains relatively high (Correa-Oliveira, et al, 2000; Ongom and Bradley 1972). …”

Section: Discussionmentioning

confidence: 99%

“…There were a few male patients with haematuria in this study but they were all negative for S. haematobium . Many studies showed that S. mansoni is the predominant species of schistosome in Uganda (Ongom and Bradley 1972; Odongo-Aginya and Mugisha, 1987). However, Schwertz 1951 and Cridland 1957 reported visceral schistosomiasis in Lango and Acholi (Schwert, 1951; Cridland, 1957).…”

Section: Discussionmentioning

confidence: 99%

“…The few patients with ascites detected in this study were all positive for S. mansoni . Ascites is an indicator of chronic schistosomiasis with enlarged liver and spleen palpable (Davis, 1993; Ongom and Bradley 1972). Histories of blood vomiting were also recorded but they were not severe oesophageal varices bleeding linked to S. mansoni .…”

Section: Discussionmentioning

confidence: 99%

“…However, factors like intensity of infections and high transmission of infections have been known to influence schistosomicidal activity of PZQ (Gryseels, 1994). In spite this fact, repeated treatment with PZQ has been shown to improve cure proportion as observed in West Nile districts of Uganda areas of high transmission and intensity (Ongom and Bradley, 1972). …”

Section: Introductionmentioning

confidence: 99%

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Evidence of long term benefit of morbidity reduction due to praziquantel treatment against Schistosoma mansoni in Kigungu fishing village in Entebbe, Uganda

Odongo-Aginya¹,

Kironde²,

Lyazi³

et al. 2011

African Journal of Infectious Diseases

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Praziquantel (PZQ) is efficacious against Schistosoma mansoni. This was prospective cohort study. This study was carried out at Kigungu fishing village, Entebbe, Uganda. The goal of the study was to establish cost effective regiment for mass drug administration (MDA) of Praziquentel in the morbidity reduction of S.mansoni infection. In January 2004, nine hundred and forty five (945) participants were registered in this study. Our analysis was based on examining microscopically three slides prepared from each of 945 stool specimens delivered by each of the participant using modified Kato/Katz method. These included male and female, children and adults living in Kigungu fishing village in Entebbe Uganda. In total 901, cohorts were re-examined for infections clearance six months later in July 2004 and 18 months later in June 2005, 625 cohorts were again re-evaluated for S.mansoni infections after the baseline study. At baseline, (448) of 945 (47.5%) cohorts were S. mansoni positive. All these participants were treatment with a single oral dose of praziquantel at 40mg/kg. At the same time, 495 (52.5%) were S. mansoni negative. Of the 625 (66.3%) cohorts who came back for final review, 80 (12.8%) were still positive for S. mansoni while 210 (33.6%) remained negative after the base line treatment with praziquantel. On the other hand 103 (16.3%) of cohorts who were initially negative at the base line became S.mansoni positive after 18 months and 213(34.1%) remained negative for S.mansoni. The force of re-infection after six months was significant {(P=0.0001), (OR 0.47) CI at 95% (0.31–0.71)}. Nevertheless the force of reinfection was not significant after 18 months {(P=0.766), (OR 0.95) CI at 95% (0.68–1.34)}.The geometric mean eggs excretion of the 80 cohorts who were S.mansoni positive at 18 months was 151.967.This did not reach the geometric mean egg excreted by the same cohorts at baseline which was 285.05. The egg excretion was reduced by 46.8%. Similarly there was marked decrease in clinical symptoms amongst the cohorts. Our study suggests evidence of long-term benefit of praziquantel in Kigungu and that a yearly administration of praziquantel to the community could be a regiment for mass drug administration (MAD) for this community to control schistosomiasis morbidity.

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Hepatic schistosomiasis

Dunn

Kamel

1981

Hepatology

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The epidemiology and consequences of Schistosoma mansoni infection in West Nile, Uganda

Cited by 89 publications

References 13 publications

Evaluation of <i>Schistosoma mansoni</i> morbidity one year after praiquantel treatment in rhino camp and Obongi in West Nile, Uganda

Evaluation of <i>Schistosoma mansoni</i> morbidity one year after praiquantel treatment in rhino camp and Obongi in West Nile, Uganda

Evidence of long term benefit of morbidity reduction due to praziquantel treatment against <i>Schistosoma mansoni</i> in Kigungu fishing village in Entebbe, Uganda

Hepatic schistosomiasis

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