The epidemiology and etiology of influenza‐like illness in Chinese children from 2008 to 2010

Peng, Jinsong; Kong, Wenhua; Guo, Deyin; Liu, Man‐Qing; Wang, Ying; Zhu, Honghao; Pang, Bei-Bei; Miao, Xiaoping; Yu, Bin; Luo, Tongyong; Hu, Qinxue; Zhou, Dun-Jin

doi:10.1002/jmv.22247

Cited by 27 publications

(24 citation statements)

References 40 publications

(35 reference statements)

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“…A prior H3N2 epidemic and a subsequent peak of influenza B were identified with the A/H1N1 2009pdm epidemic (Figure 2 and 3), which is consistent with the results of a previous influenza epidemic in children, in China [32]. However this finding differs from the patterns observed in Shenzhen, China, where epidemics of H3N2 and A/H1N1 2009pdm occurred from May to December 2009 and formed a big epidemic peak [33] and in Hong Kong, China, where the epidemics of H3N2 and A/H1N1 2009pdm occurred simultaneously between May and August 2009 [34].…”

Section: Discussionsupporting

confidence: 89%

Influenza A/H1N1 2009 Pandemic and Respiratory Virus Infections, Beijing, 2009–2010

et al. 2012

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To determine the role of the pandemic influenza A/H1N1 2009 (A/H1N1 2009pdm) in acute respiratory tract infections (ARTIs) and its impact on the epidemic of seasonal influenza viruses and other common respiratory viruses, nasal and throat swabs taken from 7,776 patients with suspected viral ARTIs from 2006 through 2010 in Beijing, China were screened by real-time PCR for influenza virus typing and subtyping and by multiplex or single PCR tests for other common respiratory viruses. We observed a distinctive dual peak pattern of influenza epidemic during the A/H1N1 2009pdm in Beijing, China, which was formed by the A/H1N1 2009pdm, and a subsequent influenza B epidemic in year 2009/2010. Our analysis also shows a small peak formed by a seasonal H3N2 epidemic prior to the A/H1N1 2009pdm peak. Parallel detection of multiple respiratory viruses shows that the epidemic of common respiratory viruses, except human rhinovirus, was delayed during the pandemic of the A/H1N1 2009pdm. The H1N1 2009pdm mainly caused upper respiratory tract infections in the sampled patients; patients infected with H1N1 2009pdm had a higher percentage of cough than those infected with seasonal influenza or other respiratory viruses. Our findings indicate that A/H1N1 2009pdm and other respiratory viruses except human rhinovirus could interfere with each other during their transmission between human beings. Understanding the mechanisms and effects of such interference is needed for effective control of future influenza epidemics.

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Section: Discussionsupporting

confidence: 89%

Influenza A/H1N1 2009 Pandemic and Respiratory Virus Infections, Beijing, 2009–2010

et al. 2012

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“…They can lead to serious diseases such as bronchiolitis and pneumonia and sometimes even cause death in infants and children worldwide [15]. In China, the positive rates of respiratory viruses in children with ARTIs or influenza-like illness (ILI) range from 37.6 to 78.7 % [5][6][7][8][9][10][11][12][13]. The positive rates appear to be slightly different in different regions, which may be attributed to different years and regional variation, as well as a lack of unified methodology.…”

Section: Discussionmentioning

confidence: 99%

“…Electronic supplementary material The online version of this article (doi:10.1007/s00705-016-2866-z) contains supplementary material, which is available to authorized users. The prevalence of respiratory viruses among children with ARTIs differs in different regions, and varies over time [5][6][7][8][9][10][11][12]. It has been relatively difficult to provide realtime surveillance of ARTIs in China because of its large population, vast territory and multivariate climatic factors.…”

Section: Introductionmentioning

confidence: 99%

“…It has been relatively difficult to provide realtime surveillance of ARTIs in China because of its large population, vast territory and multivariate climatic factors. In several previous studies, the prevalence of respiratory viruses with ARTIs in Shanghai [6,7], Wuhan [5], Harbin [8], Lanzhou [9,10], Nanjing [13], Zhuhai [12] and Shantou [11] were investigated. The positive rates of respiratory viruses among patients with ARTIs in these cities were from 37.6 % to 78.7 %.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological and clinical characteristics of respiratory viral infections in children in Shanghai, China

Dong

Chen²,

Hu³

et al. 2016

Arch Virol

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Acute respiratory tract infections (ARTIs) due to various viruses are not only the most common causes of upper and lower respiratory infection but are also major causes of morbidity and mortality in children. In this study, we investigated the prevalence and clinical characteristics of children with virus-related ARTIs and determined the spectrum of respiratory viruses and their correlation with meteorological variables in Jiading District, Shanghai, China. Nasopharyngeal swabs from 2819 children with ARTIs were collected from August 2011 to December 2014, and used for detection of respiratory viruses by multiplex RT-PCR. Seventeen respiratory viruses were detected among 691 (24.5 %) of 2819 patients. The highest prevalence of respiratory viruses was detected in the age group of less than 1 year (29.0 %), and the prevalence decreased with age. This suggests that children less than one year old are the most susceptible to infection. Influenza virus (IFV) was the most frequently detected virus (5.8 %), followed by parainfluenza virus (PIV) (5.7 %), enterovirus (EV) (4.3 %), and respiratory syncytial virus (RSV) (3.6 %). Statistical analysis showed that epidemics of IFV, PIV and EV had distinct seasonal variations. Mean monthly temperature appeared to be the only meteorological factor associated with IFV and PIV infection. These findings will provide valuable information for decision-making, prevention and treatment of ARTIs in children.

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“…from lower respiratory tract), samples could be easily contaminated by respiratory conditioned pathogens. At present, the epidemiological history of influenza-like illness (ILI) and the incidence and clinical presentation of CAP caused by viruses other than influenza during an influenza epidemic season were limited [15][16][17]. In this study, we report on the surveillance of respiratory microorganisms, and its laboratory biomarkers, in CAP patients admitted to a hospital during the January to August 2016.…”

Section: Introductionmentioning

confidence: 99%

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

Lin

Chen

et al. 2019

Comparative Immunology, Microbiology and Infectious Diseases

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A B S T R A C TPurpose: The etiology of community-acquired pneumonia (CAP) in hospital patients is often ambiguous due to the limited pathogen detection. Lack of a microbiological diagnosis impairs precision treatment in CAP. Methods: Specimens collected from the lower respiratory tract of 195 CAP patients, viruses were measured by the Single-plex real-time PCR assay and the conventional culture method was exploited for bacteria. Results: Among the 195 patients, there were 46 (23.59%) pure bacterial infections, 20 (10.26%) yeast infections, 32 (16.41%) pure viral infections, 8 (4.10%) viral-yeast co-infections, and 17 (8.72%) viral-bacterial co-infections. The two most abundant bacteria were Acinetobacter baumannii and klebsiella pneumoniae, whereas the most common virus was influenza A. Conclusions: Non-influenza respiratory microorganisms frequently co-circulated during the epidemic peaks of influenza, which easily being ignored in CAP therapy. In patients with bacterial and viral co-infections, identifying the etiologic agent is crucial for patient's therapy. infection enhanced susceptibility to pneumococcal pneumonia by about

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The epidemiology and etiology of influenza‐like illness in Chinese children from 2008 to 2010

Cited by 27 publications

References 40 publications

Influenza A/H1N1 2009 Pandemic and Respiratory Virus Infections, Beijing, 2009–2010

Influenza A/H1N1 2009 Pandemic and Respiratory Virus Infections, Beijing, 2009–2010

Epidemiological and clinical characteristics of respiratory viral infections in children in Shanghai, China

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

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