The Epidemiology and Management of Pediatric AKI in Asia

Che, Ruochen; Quadri, Mohammed; Zhang, Aihua

doi:10.1016/j.semnephrol.2020.08.008

Cited by 5 publications

(1 citation statement)

References 129 publications

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“…The remarkable risk of postoperative AKI remains despite advancement in the perioperative management of neonates ( 2 , 4 ), constituting an impetus to the efforts for exploring modifiable risk factors. In the present study, we identified a 24.1% incidence of AKI consistent with previous studies ( 20 , 21 ). As was reported in several infant studies ( 15 , 22 – 25 ), lower preoperative SCr was the independent risk factor of cardiovascular surgery-associated AKI, especially for neonates.…”

Section: Discussionsupporting

confidence: 92%

Association of high-sensitivity C-reactive protein and anemia with acute kidney injury in neonates

et al. 2022

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BackgroundThe association of high-sensitivity C-reactive protein (hsCRP) and anemia with postoperative acute kidney injury (AKI) in neonates with congenital heart disease (CHD) is still unclear. The purpose of this study was to examine whether anemia-associated AKI is modulated by hsCRP in neonates.MethodsThis study included 253 consecutive neonatal patients who underwent CHD surgery in a national tertiary hospital. We investigated the association between postoperative AKI with baseline hsCRP, anemia, and their interaction by multivariable logistic regression analyses.ResultsThe incidence of AKI was 24.1% in the entire cohort. After being adjusted for covariates, hsCRP level was negatively correlated with AKI (P < 0.01 for 1 mg/L threshold), whereas anemia emerged as an independent risk factor of AKI (P = 0.02). In addition, there was a significant interaction between anemia and hsCRP level (P = 0.01). In neonates with hsCRP < 1 mg/L, anemia was positively associated with AKI (P = 0.03). However, no significant association was found between anemia and AKI in the context of hsCRP ≥ 1 mg/L. Combination of anemia and hsCRP < 1 mg/L was independently correlated with the risk of AKI (P < 0.01), while concomitant anemia and hsCRP ≥ 1 mg/L or hsCRP < 1 mg/L combined with non-anemia was not.ConclusionsIn neonates with CHD, the risk of anemia-associated AKI may be modulated by hsCRP level. Attention should be paid to neonates with preoperative anemia and baseline hsCRP < 1 mg/L to reduce the risk of postoperative AKI.

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