The epidemiology of acquired aplastic anemia

Young, Neal S.; Kaufman, David W.

doi:10.3324/haematol.12855

Cited by 174 publications

(138 citation statements)

References 24 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…10 Although aplastic anemia is an autoimmune disease, its incidence is equal in both sexes. 21 In the present study, the female to male ratio was as good as equal at 1.1:1.…”

Section: Discussionmentioning

confidence: 61%

Bone marrow aspiration cytology in the diagnosis of hematologic and non-hematologic diseases in a multi-specialty hospital in Nepal

et al. 2017

View full text Add to dashboard Cite

Background: Peripheral blood smear examination and other routine laboratory assays are not always sufficient to diagnose various diseases which affect the blood and bone marrow. A bone marrow aspirate examination is essential in most of the cases.Methods: This work was a hospital-based cross sectional analytical observational study carried out in the department of pathology at the Chitwan Medical College, Teaching Hospital, Nepal, over a period of 3 years from January, 2013 to December 2015. Bone marrow was aspirated from posterior superior iliac crest under local anesthesia; sternum was the alternative site in obese patients. Univariate analysis was performed for each variable using frequency distribution and means with the help of Statistical Package for Social Sciences 20.0 (SPSS 20.0) software.Results: One hundred and fifty-nine patients were included in the study. Eight cases of 'dry tap' were excluded, for whom bone marrow biopsy was advised. Anemia was the largest group followed by malignancy, infection and miscellaneous diseases. Among anemia, megaloblastic anemia was the most common, followed by aplastic anemia, dyserythropoietic anemia and myelopthisic anemia. The category 'malignancy' consisted of leukemia, multiple myeloma and myelodysplastic syndrome. Regarding individual diseases, megaloblastic anemia was the most common haematological disorder followed by immune thrombocytopenic purpura, leukemia and aplastic anemia.Conclusions: Bone marrow aspiration cytology is a mildly invasive technique which can diagnose many haematological and non-hematologic diseases that can be confirmed by more advanced investigations, if needed: serological, biochemical or molecular. However, bone marrow sample cannot be obtained (dry tap) in a proportion of cases. In such cases, a bone marrow biopsy needs to be performed.

show abstract

“…10 Although aplastic anemia is an autoimmune disease, its incidence is equal in both sexes. 21 In the present study, the female to male ratio was as good as equal at 1.1:1.…”

Section: Discussionmentioning

confidence: 61%

Bone marrow aspiration cytology in the diagnosis of hematologic and non-hematologic diseases in a multi-specialty hospital in Nepal

et al. 2017

View full text Add to dashboard Cite

show abstract

“…23 However, the marked variations in the frequency of aplastic anemia among European cities, or among regions of Thailand and China, reported in more recent papers, remain largely unexplained. 6 The incidence of AA in this study may have been affected by underreporting. In some regions the participants in the study had difficulty accessing the health services, and some cases may have remained undiagnosed.…”

Section: Discussionmentioning

confidence: 93%

“…The risk of development of autoimmune diseases has been linked to host genetics, and a few risk factors have been identified that affect the immune response and the susceptibility of the hematopoietic target cell. 6 Methodologically well-founded studies have found an incidence of AA ranging from 1.4 to 14 cases per million people, [7][8][9] with higher rates in Asian countries than in Western ones. 9,10 A study conducted in Southern Brazil, from 1999 to 2000, reported an incidence of 2.4 cases per million per year.…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study

Maluf

Hamerschlak²,

Cavalcanti

et al. 2009

Haematologica

View full text Add to dashboard Cite

show abstract

“…But it is more common among children, teenagers and also among older adults. The incidence of aplastic anemia peaks in people aged 20-25 years, and a subsequent peak is observed in people older than age 60 years [5]. The annual incidence of aplastic anemia in Europe is two cases per million populations and in USA incidence is 0.6-6.1 cases per million population; No accurate prospective data are available regarding the incidence of aplastic anemia in India.…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow Research in India: A Scientometric Study, 2003-12

Bala¹

2013

J Bone Marrow Res

View full text Add to dashboard Cite

Objectives: Analyses the Indian publications output in bone marrow research during 2003-12 on several parameters including contribution and citation impact of most productive countries, India's overall contribution, its growth pattern, citation impact, the share of international collaboration, identification of significant participating countries in India's international collaboration, contribution and impact of different types of bone marrow diseases, analyses of bone marrow research by sub-fields and by different population age groups, productivity and impact of leading Indian institutions and authors. Methods:The Scopus Citation Database has been used to retrieve the data for 10 years by searching the keywords "bone marrow" in combined Title, Abstract and Keywords field. Conclusions: Keeping in view the severity of bone marrow diseases, there is need to increase efforts in the R and D and improvement of supportive care and also need for establishing national data management infrastructure with updating/monitoring of registries along with better financial and social support initiatives in this area.

show abstract

The epidemiology of acquired aplastic anemia

Cited by 174 publications

References 24 publications

Bone marrow aspiration cytology in the diagnosis of hematologic and non-hematologic diseases in a multi-specialty hospital in Nepal

Bone marrow aspiration cytology in the diagnosis of hematologic and non-hematologic diseases in a multi-specialty hospital in Nepal

Incidence and risk factors of aplastic anemia in Latin American countries: the LATIN case-control study

Bone Marrow Research in India: A Scientometric Study, 2003-12

Contact Info

Product

Resources

About