The epidemiology of asbestos-related diseases

Nikliński, Jacek; Niklińska, Wiesława; Chyczewska, E; Laudański, J; Naumnik, Wojciech; Chyczewski, L; Pluygers, E

doi:10.1016/j.lungcan.2004.04.008

Cited by 55 publications

(30 citation statements)

References 20 publications

(21 reference statements)

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“…To date, only a handful of reports have been published detailing autoimmune disorders in asbestosexposed patients (Tellesson, 1961;Pfau et al, 2005;Noonan et al, 2006). The most typical health complications arising from asbestos exposure involve the development of malignant tumors associated with mesothelioma and lung cancers (Nicholson, 1984(Nicholson, , 2001Antman, 1986;Gruber, 1990;Niklinski et al, 2004). In addition, the incidence of solitary tumors of the larynx, bladder, and gastrointestinal tracts are reported to occur at a higher level among asbestos-exposed individuals than in the non-exposed population (Rolston and Oury, 2004).…”

Section: R E V I E W a R T I C L Ementioning

confidence: 99%

“…There may be an asbestos-induced reduced function of these cells, and these modifications of tumor immunity may make patients who have been exposed to asbestos more sensitive to tumor development after a latent period of 30-40 years (Nicholson, 1984(Nicholson, , 2001Antman, 1986;Gruber, 1990;Niklinski et al, 2004).…”

Section: Disruption Of Tumor Immunity Due To Asbestos Fibersmentioning

confidence: 99%

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Dysregulation of the immune system caused by silica and asbestos

Maeda

Nishimura

Kumagai

et al. 2010

Journal of Immunotoxicology

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Section: R E V I E W a R T I C L Ementioning

confidence: 99%

Section: Disruption Of Tumor Immunity Due To Asbestos Fibersmentioning

confidence: 99%

Dysregulation of the immune system caused by silica and asbestos

Maeda

Nishimura

Kumagai

et al. 2010

Journal of Immunotoxicology

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“…Exposures continue to occur in a variety of occupations, including extraction industries and building construction, particularly heating, insulation, and cement products (Niklinski et al, 2004). In addition, environmental exposures have occurred in communities such as Libby MT where asbestos-contaminated vermiculite from the nearby vermiculite mine was used throughout the community (Peipins et al, 2003) and shipped to processing plants in many locations throughout the United States.…”

Section: Introductionmentioning

confidence: 99%

Asbestos-Induced Autoimmunity in C57Bl/6 Mice

Pfau

Sentissi

et al. 2008

Journal of Immunotoxicology

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Environmental impacts on autoimmunity have significant public health implications. Epidemiological studies have shown associations between exposure to airborne silicates, such as crystalline silica or asbestos, and autoimmunity, but the etiology remains unclear. The purpose of this study was to test the hypothesis that asbestos could lead to a specific pattern of autoantibodies and pathology indicative of systemic autoimmune disease (SAID). Female C57Bl/6 mice were instilled intratracheally with 2 doses × 60 µg/mouse of amphibole asbestos (tremolite), wollastonite (a nonfibrogenic control fiber), or saline alone. Serum samples were collected and urine was checked for protein bi-weekly for 7 months. By 26 weeks, the asbestos-instilled animals had a significantly higher frequency of positive anti-nuclear antibody (ANA) tests compared to wollastonite and saline groups. The majority of positive ANAs showed homogeneous or combined homogeneous/speckled patterns, and tested positive for antibodies to dsDNA and SSA/Ro 52. Serum isotyping showed no significant changes in IgM, IgA, or IgG subclasses. However, there was an overall decrease in the mean IgG serum concentration in asbestos-instilled mice. IgG immune complex deposition was demonstrated in the kidneys of asbestos-instilled mice, with evidence of glomerular and tubule abnormalities suggestive of glomerulonephritis. Flow cytometry demonstrated moderate changes in the percentages of CD25 + Tsuppressor cells and B1a B-cells in the superficial cervical lymph nodes of the asbestos-instilled mice. These data demonstrate that asbestos leads to immunologic changes consistent with the development of autoimmunity. This study provides a non-autoimmune prone murine model for use in future elucidation of mechanisms involved in asbestos-induced autoimmune disease.

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“…Due to their outstanding characteristics, asbestos fibers were used in more than 3000 industrial applications and for manufacturing various types of products (e.g., asbestos cement, eternit, disc brake pads) known as asbestos-containing materials (ACMs) from 1720 until the 1980s [4]. The associated occupational health hazards have been investigated and identified [5][6][7][8]. In Europe and several other countries, the asbestos prohibition laws [9] banning the use of asbestos fibers have reduced the number of workers currently exposed to asbestos.…”

Section: Introductionmentioning

confidence: 99%

Multi-Analytical Approach for Identifying Asbestos Minerals In Situ

Bloise

Miriello

2018

Geosciences

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An innovative and, as yet, untested approach is to analyze serpentinite and metabasite rocks containing asbestos using a portable multi-analytical device, which combines portable digital microscopy (p-DM), portable X-ray Fluorescence (p-XRF) and portable micro-Raman Spectroscopy (p-µR). The analyses were carried out in two inactive quarries of serpentinitic and metabasitic rocks from the Gimigliano-Mount Reventino Unit (Southern Italy) already characterized in previous studies, with the aim of testing the efficiency of these portable tools. In this study, a portable X-ray fluorescence analyzer was used to obtain the in situ rapid chemical discrimination of serpentinite and metabasite rocks. The characterization of outcropping rocks using portable devices enabled us to detect the presence of chrysotile and asbestos tremolite. The results obtained were consistent with the findings from previous research studies and therefore combining p-DM, p-XRF and p-µR could be a useful approach for discriminating asbestos contained in outcropping rocks, especially when sampling is prohibited or for field-based sampling.

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The epidemiology of asbestos-related diseases

Cited by 55 publications

References 20 publications

Dysregulation of the immune system caused by silica and asbestos

Dysregulation of the immune system caused by silica and asbestos

Asbestos-Induced Autoimmunity in C57Bl/6 Mice

Multi-Analytical Approach for Identifying Asbestos Minerals In Situ

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