The Epidemiology of Brain and Spinal Cord Tumors

Shobeiri, Parnian; Seyedmirzaei, Homa; Kalantari, Amirali; Mohammadi, Esmaeil; Rezaei, Nima; Hanaei, Sara

doi:10.1007/978-3-031-14732-6_2

Cited by 11 publications

(2 citation statements)

References 175 publications

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“…Pediatric brain tumors, a significant cause of mortality in children, have an annual incidence of about 3 per 100,000 children (Abbas et al, 2021 ). The prevalence of brain tumors is influenced by factors such as age, gender, race, and region, with variations observed in different populations (Shobeiri et al, 2023 ). Wijethilake et al ( 2021 ) in their paper explores the critical task of survival analysis in glioma patients, highlighting the integration of imaging and genetic data through advanced technologies to improve survival estimation.…”

Section: Introductionmentioning

confidence: 99%

Enhancing brain tumor detection in MRI with a rotation invariant Vision Transformer

Krishnan,

Krishnadoss,

Khandelwal

et al. 2024

Front. Neuroinform.

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BackgroundThe Rotation Invariant Vision Transformer (RViT) is a novel deep learning model tailored for brain tumor classification using MRI scans.MethodsRViT incorporates rotated patch embeddings to enhance the accuracy of brain tumor identification.ResultsEvaluation on the Brain Tumor MRI Dataset from Kaggle demonstrates RViT's superior performance with sensitivity (1.0), specificity (0.975), F1-score (0.984), Matthew's Correlation Coefficient (MCC) (0.972), and an overall accuracy of 0.986.ConclusionRViT outperforms the standard Vision Transformer model and several existing techniques, highlighting its efficacy in medical imaging. The study confirms that integrating rotational patch embeddings improves the model's capability to handle diverse orientations, a common challenge in tumor imaging. The specialized architecture and rotational invariance approach of RViT have the potential to enhance current methodologies for brain tumor detection and extend to other complex imaging tasks.

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Section: Introductionmentioning

confidence: 99%

Enhancing brain tumor detection in MRI with a rotation invariant Vision Transformer

Krishnan,

Krishnadoss,

Khandelwal

et al. 2024

Front. Neuroinform.

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“…Glioblastoma multiforme (GBM) has no cure, and intertumoural or intratumour heterogeneity is one of the hallmarks of this cancer. The development of GBM is characterized by age, sex, race, genetic disorders, and ionizing radiation (7). In GBM, cellular heterogeneity is associated with therapeutic and drug resistance due to an array of genetic alterations involved in the control of cell cycle kinetics, cell growth, apoptosis, cell invasion and neovascularization (8,9).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative activity of Hoslundia opposita leaf extract and fractions against a human glioblastoma cell line (U251)

Ajibare,

Ebuehi,

Adisa

et al. 2024

Preprint

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BACKGROUND: The ineffectiveness of many known anticancer agents for treating several cancer types, especially glioblastoma (GMB), which affects the body's central nervous system, is highly important. GBM is highly invasive and recalcitrant and accountsfor 42% of all central nervous system tumors and 60% of all brain tumors in adults, with a median survival of 15 months. The limitationsencountered in GBM treatment necessitate the discovery and development of new drugs. METHODS: To investigate the anticancer activity of Hoslundia oppositaleaf extracts and fractions against a human glioblastoma cell line (U251) and human keratinocyte HACAT cell line, standard methods, MTT, clonogenic and caspase3 and 7 assays were used to determine the viability of the cells and colony formation and apoptotic activities, respectively. The fluorescent probe dyes dihydrofluorescindiacetate (DCFH-DA) and tetramethylrhodamine (TMRE) were used to determinethe intracellular reactive oxygen species (ROS) concentration and mitochondrial membrane potential (MMP), respectively, in the cells. RESULTS: The crudemethanolic extracts and fractions of H. opposita leaves exhibited moderate cytotoxic and selective activity within the range of concentrations tested (25-100 µg/ml). The study revealed that crude AHO1 and specific fractions of AHO5 and AHO6 inhibitedmetastasis or colony formation, promoted apoptosis in the U251 cell line and depolarized the mitochondrial membrane potential, which was likelymediated by mitochondria-dependent ROS generation. Overall, the specificity and dose dependenceof the different treatments were observed for the U251 cell line. Conclusions: The antiproliferative activities of Hoslundia opposita Vahl demonstrated by the crude extract and specific fractions against U251 cells warrant further investigations todecipher its mechanism of action.

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Alterations in hypothalamic-pituitary axis (HPA) hormones 6 months after cranial radiotherapy in adult patients with primary brain tumors outside the HPA region

Shahriari,

Etemadrezaie,

Zabihyan

et al. 2024

Mol Biol Rep

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The Epidemiology of Brain and Spinal Cord Tumors

Cited by 11 publications

References 175 publications

Enhancing brain tumor detection in MRI with a rotation invariant Vision Transformer

Enhancing brain tumor detection in MRI with a rotation invariant Vision Transformer

Antiproliferative activity of Hoslundia opposita leaf extract and fractions against a human glioblastoma cell line (U251)

Alterations in hypothalamic-pituitary axis (HPA) hormones 6 months after cranial radiotherapy in adult patients with primary brain tumors outside the HPA region

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