The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014

Tish, Shahed; Habboub, Ghaith; Jones, J. Stephen; Ostrom, Quinn T.; Kruchko, Carol; Barnholtz‐Sloan, Jill S.; Recinos, Pablo F.; Kshettry, Varun R.

doi:10.1007/s11060-019-03144-9

Cited by 32 publications

(22 citation statements)

References 23 publications

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“…3 EVNs are a rare entity associated with a more aggressive biological behavior than central neurocytoma; the largest epidemiology study for these tumors reports an incidence rate of 0.009 per 100,000 for EVN with rates per location in frontal lobe 0.002, temporal lobe 0.001, parietal lobe 0.001, ventricle not otherwise specified 0.022, and cerebellum not otherwise specified 0.002. 4 In the case of our patient, the lesion was evidenced at the parietal level, being the third most frequent location for this type of pathology. Many reports a mean age of presentation for EVNs around 27 years, the range varies from 2 to 75 years, and pediatric presentation as rare but known; however, the peak incidence rate was noted in the 20 to 34 age group.…”

Section: Discussionsupporting

confidence: 48%

“…Many reports a mean age of presentation for EVNs around 27 years, the range varies from 2 to 75 years, and pediatric presentation as rare but known; however, the peak incidence rate was noted in the 20 to 34 age group. 4,5 Symptom onset may vary from 3 months to 10 years and the average duration of clinical symptoms and signs of 32.4 months. 5 The most common clinical presentation is related to a raise intracranial pressure but may vary depending on tumor location, from seizure to gait disturbances among others such as numbness or motor alterations.…”

Section: Discussionmentioning

confidence: 99%

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Extraventricular Neurocytoma in Parietal Lobe

Gallego-Henao

Ramos-Delgado

Moreno-Blanco

et al. 2021

Indian Journal of Neurosurgery

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Extraventricular neurocytoma (EVN) was classified as a World Health Organization (WHO) grade II tumor; however, EVN is not fully understood; it presents a variable histological feature that included oligodendroglioma-like, neuropil-like matrix, ganglion or gangloid cells, perivascular pseudorosettes, vessel hyalinization, calcifications, and myxoid degeneration. In some very rare cases, atypical histological features such as increased mitotic figures, focal necrosis, endothelial cell proliferation, and Ki-67 index of >2% made this tumor more aggressive and more susceptible to recur. We present the case of a young patient who presents with a 2-year history of seizure without other symptoms. Magnetic resonance imaging reveals a parietal lobe and well-circumscribed lesion treated by gross total resection and adjuvant radiotherapy. Clear guidelines to treat this kind of lesions are not well established and there is not a consensus of correct treatment in these tumors.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Extraventricular Neurocytoma in Parietal Lobe

Gallego-Henao

Ramos-Delgado

Moreno-Blanco

et al. 2021

Indian Journal of Neurosurgery

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“…Age-adjusted incidence rates and confidence intervals were calculated by age, gender, race and ethnicity." 7,12,13 SEER*Stat used methods described by Fay to calculate incidence rate ratios (IRRs) and p values. 3,6 As previously explained in the CBTRUS 2017 annual report, "Joinpoint 4.2.0.2 was used to estimate incidence time trends, and generate annual percentage change (APC) and 95% confidence intervals.…”

Section: Discussionmentioning

confidence: 99%

The epidemiology of spinal schwannoma in the United States between 2006 and 2014

Tish

Habboub

Lang

et al. 2020

Journal of Neurosurgery: Spine

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OBJECTIVESpinal schwannoma remains the third most common intradural spinal tumor following spinal meningioma and ependymoma. The available literature is generally limited to single-institution reports rather than epidemiological investigations. As of 1/1/2004, registration of all benign central nervous system tumors in the United States became mandatory after the Benign Brain Tumor Cancer Registries Amendment Act took action, which provided massive resources for United States population-based epidemiological studies. This article describes the epidemiology of spinal schwannoma in the United States from January 1, 2006, through December 31, 2014.METHODSIn this study, the authors utilized the Central Brain Tumor Registry of the United States, which corresponds to 100% of the American population. The Centers for Disease Control and Prevention’s National Program of Cancer Registries and the National Cancer Institute’s Surveillance Epidemiology and End Results program provide the resource for this data registry. The authors included diagnosis years 2006 to 2014. They used the codes per the International Coding of Diseases for Oncology, 3rd Edition: histology code 9560/0 and site codes C72.0 (spinal cord), C70.1 (spinal meninges), and C72.1 (cauda equina). Rates are per 100,000 persons and are age-adjusted to the 2000 United States standard population. The age-adjusted incidence rates and 95% confidence intervals are calculated by age, sex, race, and ethnicity.RESULTSThere were 6989 spinal schwannoma cases between the years 2006 and 2014. The yearly incidence eminently increased between 2010 and 2014. Total incidence rate was 0.24 (95% CI 0.23–0.24) per 100,000 persons. The peak adjusted incidence rate was seen in patients who ranged in age from 65 to 74 years. Spinal schwannomas were less common in females than they were in males (incidence rate ratio = 0.85; p < 0.001), and they were less common in blacks than they were in whites (IRR = 0.52; p < 0.001) and American Indians/Alaska Natives (IRR = 0.50; p < 0.001) compared to whites. There was no statistically significant difference in incidence rate between whites and Asian or Pacific Islanders (IRR = 0.92; p = 0.16).CONCLUSIONSThe authors’ study results demonstrated a steady increase in the incidence of spinal schwannomas between 2010 and 2014. Male sex and the age range 65–74 years were associated with higher incidence rates of spinal schwannomas, whereas black and American Indian/Alaska Native races were associated with lower incidence rates. The present study represents the most thorough assessment of spinal schwannoma epidemiology in the American population.

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“…Previous limitations in diagnosis were related to limited ability to elicit radiographic differences, scant material for pathological analysis and the overall rarity of glioneuronal tumors. Ganglioglioma, paraganglioma, central neurocytoma and DNET have been reported on for some time (Figure 1) (1)(2)(3)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). RGNT (39)(40)(41), PGNT (42,43) and GNTNI (44) were added to the WHO classification in 2007 (1).…”

Section: Pathological Molecular and Imaging Featuresmentioning

confidence: 99%

Glioneuronal Tumors: Insights into a Rare Tumor Entity

Krauze

2021

Gliomas

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Glioneuronal tumors are a group of rare neoplasms made up of neural and glial components in heterogenous proportions, generally exhibiting WHO grade I clinical behavior. These tumors affect infants, children and young adults, but are also described in adults and the elderly. They are strongly associated with seizures. Tumor subtypes described under the umbrella of glioneuronal tumors are actively evolving but to date comprise central, extraventricular and lipo-neurocytoma, desmoplastic infantile astrocytoma and ganglioglioma, diffuse leptomeningeal glioneuronal tumor, dysembryoplastic neuroepithelial tumor, papillary glioneuronal tumor, rosette-forming glioneuronal tumor of the fourth ventricle, rosetted glioneuronal tumor with neuropil-like islands, gangliocytoma, ganglioglioma, anaplastic ganglioglioma and paraganglioma. They vary in radiographic appearance, with some exhibiting large heterogenous solid/cystic masses. With large scale genetic and molecular analyses ongoing, classification continues to evolve. Seizure management and surgical resection represent the cornerstones of management, with the use of systemic agents and radiation lacking conclusive results. Optimal management requires multidisciplinary discussion including

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The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014

Cited by 32 publications

References 23 publications

Extraventricular Neurocytoma in Parietal Lobe

Extraventricular Neurocytoma in Parietal Lobe

The epidemiology of spinal schwannoma in the United States between 2006 and 2014

Glioneuronal Tumors: Insights into a Rare Tumor Entity

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