The epidemiology of coeliac disease in East Dorset 1993-2002: An assessment of the 'coeliac iceberg', and preliminary evidence of case clustering

Fowell, Andrew; Thomas, Peter; Surgenor, Susan L; Snook, Jonathon

doi:10.1093/qjmed/hcl061

Cited by 23 publications

(18 citation statements)

References 27 publications

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“…Twice as many women were diagnosed as men and the proportion presenting with non-specific symptoms rose dramatically through the study period while the number with diarrhoea declined; these features have been commented on in recent studies. [2][3][4] A further investigation from Derby found that the number of diagnoses was eightfold higher in the quinquennium 2001-2005 compared with 1981-1985. 5 Others have reported an increased prevalence of CD through the years in this country and abroad.…”

Section: Introductionmentioning

confidence: 96%

“…A study of CD from Dorset, UK, covering the years 1993-2002 revealed an increase from 6 to 13.3 patients per 100 000 population over this period. 2 A report from North America found an increase in prevalence from 11.1 per 100 000 person-years in 2000-2001 to 17.3 in 2008-2010 but only a small number of patients with CD was included. 6 Another series from the USA found a fivefold increase in the prevalence of CD between 1999 and 2008 but only military personnel were considered.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of coeliac disease in a single centre in Southern Derbyshire 1958–2014

Holmes

Muirhead

2017

BMJ Open Gastroenterol

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ObjectiveTo determine trends in diagnosis of coeliac disease (CD) in patients attending a single centre 1958–2014 and provide figures for prevalence and incidence in those born in Derby city over 4 decades. To explore a link between deprivation and prevalence and characteristics of CD in Asians.DesignAn unselected, consecutive series of 2410 adult patients with CD diagnosed in the catchment area of the Derby hospitals was identified. 1077 born within Derby city identified by postcodes was used to determine changes in prevalence and incidence over 4 decades. 191 patients were Asian. Population numbers were obtained from National Census information.ResultsIn the quinquennium 2010–2014, 20 times more patients were diagnosed than during 1975–1979. 27% were diagnosed at ≥60 years. A paucity of diagnoses in young men was observed. Women were diagnosed most often in age band ≥35<45, 15 years earlier than men. The largest increase in diagnosis rates occurred in young women and the elderly. In 2014, overall prevalence was 1:188; women 1:138. 4.6% of the variation was attributed to deprivation. Diagnosis rates in Asians increased markedly although only 5% were diagnosed at ≥60 years, much lower than for whites.ConclusionsThe dramatic increase in number of patients with CD presents challenges for follow-up and new models of care need to be explored. Healthcare workers should be alert to the diagnosis in young men and elderly Asians. A dedicated coeliac clinic is an excellent facility to increase diagnosis rates.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Epidemiology of coeliac disease in a single centre in Southern Derbyshire 1958–2014

Holmes

Muirhead

2017

BMJ Open Gastroenterol

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“…Those that have been published (10,11,12,13,14,15) are very small, have not included all age groups (16), are neither population based nor nationwide (having focussed on, for example, only US military personnel (17) or specific regions of a country (4,18), and have used variable disease definitions (19). Some incidence studies among children have shown a two- to threefold increase in incidence of CD in Denmark and Sweden over a 13-year period (5,8) and another study in Scotland has shown a sixfold increase over 20 years (20), but no general population-based longitudinal data (over multiple decades) are available for all regions of a nation for adult CD.…”

Section: Introductionmentioning

confidence: 99%

Incidence and Prevalence of Celiac Disease and Dermatitis Herpetiformis in the UK Over Two Decades: Population-Based Study

West

Fleming

Tata

et al. 2014

American Journal of Gastroenterology

240

202

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OBJECTIVES:Few studies have quantified the incidence and prevalence of celiac disease (CD) and dermatitis herpetiformis (DH) nationally and regionally by time and age groups. Understanding this epidemiology is crucial for hypothesizing about causes and quantifying the burden of disease.METHODS:Patients with CD or DH were identified in the Clinical Practice Research Datalink between 1990 and 2011. Incidence rates and prevalence were calculated by age, sex, year, and region of residence. Incidence rate ratios (IRR) adjusted for age, sex, and region were calculated with Poisson regression.RESULTS:A total of 9,087 incident cases of CD and 809 incident cases of DH were identified. Between 1990 and 2011, the incidence rate of CD increased from 5.2 per 100,000 (95% confidence interval (CI), 3.8–6.8) to 19.1 per 100,000 person-years (95% CI, 17.8–20.5; IRR, 3.6; 95% CI, 2.7–4.8). The incidence of DH decreased over the same time period from 1.8 per 100,000 to 0.8 per 100,000 person-years (average annual IRR, 0.96; 95% CI, 0.94–0.97). The absolute incidence of CD per 100,000 person-years ranged from 22.3 in Northern Ireland to 10 in London. There were large regional variations in prevalence for CD but not DH.CONCLUSIONS:We found a fourfold increase in the incidence of CD in the United Kingdom over 22 years, with large regional variations in prevalence. This contrasted with a 4% annual decrease in the incidence of DH, with minimal regional variations in prevalence. These contrasts could reflect differences in diagnosis between CD (serological diagnosis and case finding) and DH (symptomatic presentation) or the possibility that diagnosing and treating CD prevents the development of DH.

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“…[7,8], в период с 1993 по 2002 г. отмечено уве-личение заболеваемости с 6 до 13,3 на 100 тыс. [9]. В Северной Америке в период с 2000 по 2001 г. зарегистрировано повышение заболеваемости целиакией с 11,1 до 17,3 на 100 тыс.…”

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Global epidemiology of celiac disease

2018

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The epidemiology of coeliac disease in East Dorset 1993-2002: An assessment of the 'coeliac iceberg', and preliminary evidence of case clustering

Cited by 23 publications

References 27 publications

Epidemiology of coeliac disease in a single centre in Southern Derbyshire 1958–2014

Epidemiology of coeliac disease in a single centre in Southern Derbyshire 1958–2014

Incidence and Prevalence of Celiac Disease and Dermatitis Herpetiformis in the UK Over Two Decades: Population-Based Study

Global epidemiology of celiac disease

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