The Epidemiology of COVID-19 in Pregnancy

Overton, Eve; Goffman, Dena; Friedman, Alexander M.

doi:10.1097/grf.0000000000000674

Cited by 53 publications

(49 citation statements)

References 56 publications

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“…After the discovery of covid-19 during a recent epidemic in China, (1,2) now the virus has spread around the world, infecting 250 million individuals and resulted in 5 million death as of Nov, 2021. (3) Infected Patients could present with mild to moderate symptoms, but the majority of individuals will be asymptomatic carrier of the disease. Infected individuals usually present with the prevalent symptoms of cough, fever, and dyspnea.…”

Section: Ntroductionmentioning

confidence: 99%

Prediction of Complications and Death in Covid-19 Patients with Deranged Liver Function Tests at Time of Admission and Hospitalization

Kamran¹,

Ahmad²,

Farhin³

et al. 2022

PJMHS

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COVID-19 pandemic has affected millions of individuals globally over the last three years and is spreading continuously. In view of different studies and clinical findings, patients suffering with COVID-19 frequently have deranged liver function tests (LFTs), but the clinical significance of this finding is debatable. Objective: The present study was aimed to estimate the prevalence, features, and clinical significance of deranged LFTs in COVID-19 infected individuals, who were hospitalized but were not critically ill. Method: We conducted a cross sectional from May 2021 to December 2021 at The Akbar Niazi Teaching Hospital Islamabd. A total of 250 COVID-19 patients were included in the current study. The patient's blood samples were collected to get laboratory results, which included LFTs. LFTs were performed at the time of admission and every 5 ± 2 day throughout the stay. The outcome measure was either death or transfer of the patients to an intensive care unit. Results: At the time of admission, 160 patients (64%) showed deranged LFTs. Individuals with deranged LFTs experienced more severe inflammation, swelling, and organ damage than those who didn’t. Patients with deranged LFTs had a greater proportion of transfer to the ICU (81 vs 17), hospital stay (17 vs 7 days), and death (17 vs 5) than those with normal LFTs. Conclusion: The results of the current investigation demonstrated that LFTs data might forecast the degree of illness in patients with COVID-19 infections at the time of admission and during their hospital stay. Keywords: Covid-19, Liver Function Tests, ICU, Mortality Rate, Pakistan

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Section: Ntroductionmentioning

confidence: 99%

Prediction of Complications and Death in Covid-19 Patients with Deranged Liver Function Tests at Time of Admission and Hospitalization

Kamran¹,

Ahmad²,

Farhin³

et al. 2022

PJMHS

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show abstract

“…Pregnancy and the postpartum period impart physiological, hormonal and immunologic changes that are associated with decreased ability to clear infections and a hypercoagulable state, ( Abu-Raya et al, 2020 ) , ( Overton et al, 2022 ) raising particular concerns for pregnant women with COVID-19. Indeed, worse COVID-19 outcomes are consistently observed in pregnant and postpartum women versus non-pregnant counterparts.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 in the pregnant or postpartum MS patient: Symptoms and outcomes

Salter

Cross

Cutter

et al. 2022

Multiple Sclerosis and Related Disorders

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Section: Introductionmentioning

confidence: 99%

“…In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began spreading, rapidly leading to a global pandemic [ 1 , 2 ]. Pregnant persons are considered a high-risk population during infectious disease outbreaks as they have increased susceptibility to infections and its sequelae due to the physiological changes of pregnancy [ 2 , 3 ]. The clinical presentation of Coronavirus Disease 2019 (COVID-19) in pregnancy is variable and can range in severity from asymptomatic to critical illness with acute respiratory distress syndrome (ARDS), multiorgan failure, and in some cases, death [ 1 , 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Severe COVID-19 in pregnancy has a distinct serum profile, including greater complement activation and dysregulation of serum lipids

Altendahl

Mok²,

Jang³

et al. 2022

PLoS ONE

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Background Pregnancies complicated by Coronavirus Disease 2019 (COVID-19) are at an increased risk of severe morbidity due to physiologic changes in immunologic, cardiovascular, and respiratory function. There is little is known about how severity of COVID-19 changes protein and metabolite expression in pregnancy. Objective This study aims to investigate the pathophysiology behind various clinical trajectories in pregnant patients diagnosed with COVID-19 using multi-omics profiling. Study design This is a prospective cohort study of 30 pregnant patients at a single tertiary care center. Participants were categorized by severity of COVID-19 disease (control, asymptomatic, mild/moderate, or severe). Maternal serum samples underwent LC-MS-based multiomics analysis for profiling of proteins, lipids, electrolytes, and metabolites. Linear regression models were used to assess how disease severity related to analyte levels. Reactome pathway enrichment analysis was conducted on differential analytes. Results Of 30 participants, 25 had confirmed diagnosis of COVID-19 (6 asymptomatic (one post-infection), 13 mild/moderate (all post-infection), 6 severe), and 5 participants were controls. Severe COVID-19 was associated with distinct profiles demonstrating significant proteomic and lipidomic signatures which were enriched for annotations related to complement and antibody activity. (FDR < 0.05). Downregulated analytes were not significantly enriched but consisted of annotation terms related to lipoprotein activity (FDR > 0.2). Post-infection mild/moderate COVID-19 did not have significantly altered serum protein, metabolite, or lipid metabolite levels compared to controls. Conclusions Pregnancies with severe COVID-19 demonstrate greater inflammation and complement activation and dysregulation of serum lipids. This altered multiomic expression provides insight into the pathophysiology of severe COVID-19 in pregnancy and may serve as potential indicators for adverse pregnancy outcomes.

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The Epidemiology of COVID-19 in Pregnancy

Cited by 53 publications

References 56 publications

Prediction of Complications and Death in Covid-19 Patients with Deranged Liver Function Tests at Time of Admission and Hospitalization

Prediction of Complications and Death in Covid-19 Patients with Deranged Liver Function Tests at Time of Admission and Hospitalization

COVID-19 in the pregnant or postpartum MS patient: Symptoms and outcomes

Severe COVID-19 in pregnancy has a distinct serum profile, including greater complement activation and dysregulation of serum lipids

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