The Epidemiology of Diabetic Nephropathy

Kim, Jin Hwa

doi:10.4093/jkd.2013.14.1.11

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…In addition, the aging society proceeds quickly, thereby the number of diabetes patients are predicted about 6 million in 2050, approximately a 2-fold increase compared to the current number of diabetes patients [ 1 , 2 ]. Also, the incidence of acute and chronic complications associated with diabetes is expected to increase [ 2 , 3 ]. Especially diabetic nephropathy occurs more frequently among the patients suffered from diabetes for a long time.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Intervention for a Patient with Diabetic Nephropathy

Kim

2014

Clin Nutr Res

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In recent years, several studies have reported that the prevalence of diabetes mellitus is increasing every year, and also the acute and chronic complications accompanying this disease are increasing. Diabetic nephropathy is one of chronic complications of diabetes mellitus, and food intake which is burden to kidney function should be limited. At the same time, diet restriction could deteriorate quality of life of patient with diabetic nephropathy. According to the results of previous studies, the aggressive management is important for delaying of the progression to diabetic nephropathy. Also, the implementation of a personalized diet customized to individuals is an effective tool for preservation of kidney function. This is a case report of a patient with diabetic nephropathy who was introduced to a proper diet through nutrition education to prevent malnutrition, uremia and to maintain blood glucose levels.

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Section: Introductionmentioning

confidence: 99%

Nutritional Intervention for a Patient with Diabetic Nephropathy

Kim

2014

Clin Nutr Res

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Study of Glucose Binding Protein Encapsulated Gold Nanoclusters by Molecular Dynamic Simulation

Panjaitan

Kubiak-Ossowska

Birch

et al. 2019

MSF

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Protein encapsulated gold nanoclusters has attracted great attention for their excellent fluorescent properties and potential biomedical applications. Glucose Binding Protein (GBP) has a high sensitivity and selectivity to glucose binding that makes them ideal for biosensor development. It is anticipated that GBP encapsulated gold nanoclusters could be a promising glucose sensor. Here we investigated the growth of gold nanoclusters in GBP using Molecular Dynamics (MD) simulation. To facilitation the nucleation of gold nanoclusters at specific sites, cysteine mutations were introduced in GBP. It is found that the nucleation site of gold nanoclusters inside mutant GBP are different from those in native GBP. Gold nanoclusters were formed near the mutated cysteine and tyrosine residues. Glucose remained in the binding site of a mutant GBP with gold nanoclusters although no conformational change was observed in MD simulation, similar to a native GBP. This work suggests the possibility of growing gold nanoclusters in the designed site within GBP and a new glucose sensor based on mutated GBP protected gold nanoclusters.

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The Epidemiology of Diabetic Nephropathy

Cited by 2 publications

References 18 publications

Nutritional Intervention for a Patient with Diabetic Nephropathy

Nutritional Intervention for a Patient with Diabetic Nephropathy

Study of Glucose Binding Protein Encapsulated Gold Nanoclusters by Molecular Dynamic Simulation

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