The Epidemiology of Drinking Among Women of Child‐Bearing Age

Caetano, Raúl; Ramisetty-Mikler, Suhasini; Floyd, L. R.; McGrath, Christine J.

doi:10.1111/j.1530-0277.2006.00116.x

Cited by 130 publications

(119 citation statements)

References 36 publications

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“…In line with previous research, our research identified age as influential in terms of mothers' alcohol use [1][2][3][4][5][6][7][8][9][10]. Mothers linked youth with heavy alcohol consumption and frequent small quantities of alcohol use were considered indicative of older age groups.…”

Section: Discussionsupporting

confidence: 64%

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Patterns and Perceptions of Maternal Alcohol Use among Women with Pre-School Aged Children: A Qualitative Exploration of Focus Group Data

Baker¹

2017

J Addict Res Ther

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Background: Quantitative studies of women's alcohol use suggest that social advantage is associated with increased frequency of alcohol use and disadvantage with increased quantities. Very few studies have examined patterns among mothers; even fewer have explored mothers' perceptions and understandings of their alcohol use. We examine how mothers describe and make sense of their patterns of alcohol use in the context of advantaged and disadvantaged circumstances.

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Section: Discussionsupporting

confidence: 64%

“…There is evidence that problematic alcohol use (DSM-III-R, CAGE criteria) and binge drinking (>4 drinks, >60 g alcohol per occasion) among women is negatively associated with age [1][2][3][4][5][6][7][8][9][10]. Social gradients in alcohol use have also been identified amongst women [11] and young adults [12].…”

Section: Introductionmentioning

confidence: 99%

Patterns and Perceptions of Maternal Alcohol Use among Women with Pre-School Aged Children: A Qualitative Exploration of Focus Group Data

Baker¹

2017

J Addict Res Ther

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“…First, binge drinking is more clinically relevant than continuous alcohol exposure (Caetano et al, 2006). For reference, the amount of alcohol needed to bring human alcohol blood level to 200 mg/dL -as in our sheep -is 7 ounces of hard liquor or 7 beers consumed over a 90 minute period.…”

Section: Discussionmentioning

confidence: 99%

Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar function in third trimester fetal sheep

et al. 2008

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Fetal alcohol syndrome is a leading cause of mental retardation, but mechanisms of alcoholassociated brain damage remain elusive. Chronic alcohol exposure attenuates fetal and neonatal hypoxic cerebral vasodilation in sheep. We therefore hypothesized that alcohol could alter development of cerebrovascular responses to adenosine, a putative mediator of hypoxic cerebral vasodilation. The objective of this study was to examine the effect of earlier fetal alcohol exposure on later reactivity to adenosine in fetal sheep cerebral arterioles. Penetrating intracerebral arterioles were harvested from the brains of third trimester fetal sheep previously exposed in the second trimester to maternal alcohol "binges" (1.5g/kg IV over 90 minutes, 5 days/week for 4 weeks) or same-volume saline infusions. Arterioles were cannulated with a micropipette system and luminally pressurized. Fetal alcohol exposure did not affect spontaneous myogenic tone, but enhanced the dilator response of penetrating arterioles to extraluminal acidosis (pH 6.8). Alcohol exposure also resulted in an increase in maximal vessel response to CGS-21680, an adenosine A 2A receptor agonist, but did not alter the concentration-dependent response curves to adenosine. Our results suggest that earlier alcohol exposure does not impair the subsequent responsiveness of fetal cerebral arterioles to vasodilator agents. Thus, alteration in cerebral vascular response to hypoxia in fetal sheep may not be attributed to changes in vascular reactivity to adenosine.

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“…The prevalence of alcohol consumption among women of child-bearing age remains essentially unchanged despite considerable efforts to educate women about the harmful consequences of alcohol consumption during pregnancy (Caetano et al, 2006;CDC, 2004;Institute of Medicine, 1996;Maternal and Child Health (MCH) Data Report, 2003;NIAAA, 2000) requiring the need to consider other approaches to reduce the negative impact of prenatal alcohol exposure (Cudd, 2005). Numerous hypotheses have been proposed to account for the teratogenic effects of alcohol of which alcohol induced alterations in hypothalamic-pituitaryadrenal (HPA) axis, and hypothalamus-pituitary-thyroid (HPT) axis function are popular (For review, see Zhang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In this study we characterized the T 3 , T 4 and free T 4 responses in pregnant sheep to alcohol exposure, but extending the duration of alcohol exposure to all three trimesterequivalents of gestation. We employed a "binge" alcohol exposure paradigm, a drinking pattern common in women who use alcohol during pregnancy (Caetano et al, 2006;Cudd et al, 2001;Ebrahim et al, 1999;Gladstone et al, 1996;Maier and West, 2001) to characterize the maternal thyroid hormones, ACTH and cortisol responses to alcohol over the entire period of gestation.…”

Section: Introductionmentioning

confidence: 99%

Maternal adrenocorticotropin, cortisol, and thyroid hormone responses to all three-trimester equivalent repeated binge alcohol exposure: ovine model

Ramadoss

Tress

Chen

et al. 2008

Alcohol

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Alcohol-mediated alterations in hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitarythyroid (HPT) axis function are two proposed mechanisms by which alcohol causes neurodevelopmental injury to the fetus. We previously reported that third trimester-equivalent only alcohol exposure in sheep results in increases in the maternal and fetal adrenocorticotropin (ACTH) and cortisol levels, and decreases in the fetal thyroid hormones T 3 and T 4 and maternal T 3 levels. In this study, we wished to characterize the maternal HPA and HPT hormone responses to repeated binge alcohol exposure during all three trimester-equivalents of pregnancy in sheep. Pregnant ewes received intravenous infusions of alcohol at doses of 0.75, 1.25 or 1.75 g/kg over 1 hour with mean peak blood alcohol concentrations of 90, 126 or 183 mg/dl respectively on three consecutive days each week beginning on gestation day (GD) 4. Maternal blood samples were collected on GDs 6, 40, 90, and 132. Maternal plasma concentrations of ACTH and cortisol increased in response to the high alcohol dose, and the magnitude of these elevations was not different across gestation. Thyroid hormone levels were not different when comparing among treatment groups at any time point during gestation. However, there was an ontogenetic decrease in the maternal T 3 concentration beginning between GDs 6 and 40 and a decrease in maternal T 4 and free T 4 beginning between GDs 40 and 90. The current findings suggest that: 1) maternal alcohol consumption at any time during gestation stimulates the HPA axis, 2) maternal HPA responsiveness to alcohol does not change across gestation, 3) binge alcohol exposure at these doses lasting all three trimester equivalent of human brain development does not reduce maternal thyroid hormone concentration, 4) alterations in fetal thyroid function in response to alcohol exposure do not occur as a result of diminished maternal thyroid hormone contribution, and 5) there is an ontogenetic decrease in ovine maternal thyroid hormones over gestation.

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The Epidemiology of Drinking Among Women of Child‐Bearing Age

Abstract: Drinking and heavier drinking remain at high levels among women of child-bearing age. Prevention efforts must be comprehensive and should target pregnant women who are drinking and those who could become pregnant and are drinking at high-risk levels.

Cited by 130 publications

References 36 publications

Patterns and Perceptions of Maternal Alcohol Use among Women with Pre-School Aged Children: A Qualitative Exploration of Focus Group Data

Patterns and Perceptions of Maternal Alcohol Use among Women with Pre-School Aged Children: A Qualitative Exploration of Focus Group Data

Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar function in third trimester fetal sheep

Maternal adrenocorticotropin, cortisol, and thyroid hormone responses to all three-trimester equivalent repeated binge alcohol exposure: ovine model

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