The epidemiology of gastric cancer

CONTEXT: The most recent global estimate revealed the presence of about one million new cases of stomach cancer for the year 2008, setting itself as the fourth most common cause of cancer. OBJECTIVE: The present study aims to assess the trend of mortality from stomach cancer in Brazil according to regions between 1980 and 2009. METHODS: Data on deaths from stomach cancer were obtained from the Mortality Information System, and the demographic data, from the Brazilian Institute of Geography and Statistics. The rates of mortality were standardized by age according to world population. The trend curves were calculated for Brazilian regions by sex. The technique used was polynomial regression and joinpoint. RESULTS: The tendency for males and females is similar in all regions, although the magnitude is higher among men in all places. Regions Midwest, South, Southeast tended to decline, while the Northern region showed no significant trend, and the Northeast tended to increase. CONCLUSION: It is therefore a need to evaluate public health policies for gastric cancer aimed at the demographic transition (change of urbanization and lifestyle) that is occurring throughout the country.

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“…The Brazilian rates are higher than in developed countries such as Australia, Canada, United States, Spain, Germany and France (15,30) .…”

Section: Discussionmentioning

confidence: 99%

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Guimarães

Muzi

2012

Arq. Gastroenterol.

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“…Gastric cancer (GC) is one of the commonest malignancies worldwide, and the highest rate of GC is observed in eastern Asian countries, especially in Japan [1]. It is well known that having a first-degree relative with GC is a consistent risk factor for GC [2][3][4], especially when two or more relatives are affected [5,6].…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

et al. 2016

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Background A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/ TIMP genes. Methods We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35-69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. Results MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45-13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81-6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and

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“…1,2 Gastric cancer is the fourth most common new cancer diagnosis in the world, accounting for an estimated 876,341 new cancer cases and 646,567 deaths worldwide in 2000. 2 In human, it is rather rare to detect dysplastic lesions because these patients tend to be asymptomatic, and are only diagnosed when tumors already are present at an advanced stage.…”

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confidence: 99%

“…3 In the United States this is reflected in an overall 5-year survival rate of less than 20%. 1 Thus, identification of early genetic changes in gastric tumorigenesis is a challenging task. Mouse models of human disease are useful to explore the molecular basis of a disease that is difficult to perform in humans.…”

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confidence: 99%

Expression of Tight-Junction Protein Claudin-7 Is an Early Event in Gastric Tumorigenesis

Johnson

Frierson

Zaika

et al. 2005

The American Journal of Pathology

101

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Trefoil factor-1 (Tff1) expression is remarkably downregulated in nearly all human gastric cancers. Therefore, we used the Tff1 knockout mouse model to detect molecular changes in preneoplastic gastric dysplasia. Oligonucleotide microarray gene expression analysis of gastric dysplasia of Tff1 ؊/؊ mice was compared to that of normal gastric mucosa of wild-type mice. The genes most overexpressed in Tff1؊/؊ mice included claudin-7 (CLDN7), early growth response-1 (EGR1), and epithelial membrane protein-1 (EMP1). Quantitative real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry showed that Cldn7 was overexpressed in all 10 Tff1؊/؊ gastric dysplasia samples. Comparison with our serial analysis of gene expression database of human gastric cancer revealed similar deregulation in human gastric cancers. Quantitative real-time reverse transcriptase-polymerase chain reaction of human gastric adenocarcinoma samples indicated that, of these three genes, CLDN7 was the most frequently up-regulated gene. Using immunohistochemistry, both mouse and human gastric glands overexpressed Cldn7 in dysplastic but not surrounding normal glands. Cldn7 expression was observed in 30% of metaplasia, 80% of dysplasia, and 70% of gastric adenocarcinomas. Interestingly, 82% of human intestinal-type gastric adenocarcinomas expressed Cldn7 whereas diffuse-type gastric adenocarcinomas did not (P < 0.001). These results suggest that Cldn7 expression is an early event in gastric tumorigenesis that is maintained throughout tumor progression. Gastric carcinoma is the second leading cause of cancer mortality worldwide accounting for ϳ10% of newly diagnosed cancers.

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The epidemiology of gastric cancer

Cited by 317 publications

References 23 publications

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer

Expression of Tight-Junction Protein Claudin-7 Is an Early Event in Gastric Tumorigenesis

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