The Epidemiology of Ground Glass Opacity Lung Adenocarcinoma: A Network-Based Cumulative Meta-Analysis

Li, Xiongfei; Ren, Fan; Wang, Shuhang; He, Zhicheng; Song, Zuoqing; Xu, Song

doi:10.3389/fonc.2020.01059

Cited by 11 publications

(7 citation statements)

References 63 publications

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“…Lung cancer is one of the most common causes of cancer death, and tobacco smoking is the most well-known risk factor for lung cancer [ 1 ]. The incidence of lung cancer among never-smokers has been increasing over the past decade, and exposure to secondhand tobacco smoke, radon, and/or air pollution is considered to be a possible etiological factor [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma

Shinchi

Ishizuka

Komohara

et al. 2022

Cancer Immunol Immunother

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Programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) are target molecules for immunotherapy in non-small cell lung cancer. PD-L1 is expressed not only in cancer cells, but also on macrophages, and has been suggested to contribute to macrophage-mediated immune suppression. We examined the clinical significance of PD-L1 expression on macrophages in human lung adenocarcinoma. The mechanism of PD-L1 overexpression on macrophages was investigated by means of cell culture studies and animal studies. The results showed that high PD-L1 expression on macrophages was correlated with the presence of EGFR mutation, a lower cancer grade, and a shorter cancer-specific overall survival. In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate PD-L1 expression on macrophages via STAT3 activation, and a cytokine array revealed that granulocyte–macrophage colony-stimulating factor (GM-CSF) was a candidate factor that induced PD-L1 expression. Culture studies using recombinant GM-CSF, neutralizing antibody, and inhibitors indicated that PD-L1 overexpression was induced via STAT3 activation by GM-CSF derived from cancer cells. In a murine Lewis lung carcinoma model, anti-GM-CSF therapy inhibited cancer development via the suppression of macrophage infiltration and the promotion of lymphocyte infiltration into cancer tissue; however, the PD-L1 expression on macrophages remained unchanged. PD-L1 overexpression on macrophages via the GM-CSF/STAT3 pathway was suggested to promote cancer progression in lung adenocarcinoma. Cancer cell-derived GM-CSF might be a promising target for anti-lung cancer therapy. Supplementary Information The online version contains supplementary material available at 10.1007/s00262-022-03187-4.

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Section: Introductionmentioning

confidence: 99%

The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma

Shinchi

Ishizuka

Komohara

et al. 2022

Cancer Immunol Immunother

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“…Besides, Li et al. found the average age at diagnosis had significantly decreased from 66.40 to 59.06 in the past two decades using a cumulative meta-analysis ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our findings showed age was a key factor for risk of malignance consistent with Zhang's study. Besides, Li et al found the average age at diagnosis had significantly decreased from 66.40 to 59.06 in the past two decades using a cumulative meta-analysis (8).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Ground-Glass Nodules Detected by Low-Dose Computed Tomography as a Regular Health Examination Among Chinese Hospital Employees and Their Parents

Ouyang

et al. 2021

Front. Oncol.

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IntroductionAnnual LDCT has been offered as a regular examination among many unit staff in China. Along with the wide application of LDCT, more and more ground-glass nodules were found. We focused on characteristics and relationship of ground-glass nodules detected by LDCT as a regular health examination among Chinese hospital employees and their parents.MethodsWe recorded LDCT-detected ground-glass nodules (GGNs) in the hospital employees and parents between 2019 and 2020. Clinical information, including age, gender, smoking status was collected and analyzed.ResultsA total of 5,574 employees and 2,686 employs’ parents ≥60 years in Xiangya hospital performed annual physical examination. In total, LDCT incidentally detected ground-glass nodules 392 (24.78%, 392/1,582) in hospital employees and 254 in parents (10.80%, 254/2,352). The GGN-detection rate was significantly greater in employee group than parent group and more non-smokers in former (P <0.001). The detection rate was significantly greater in female than male both in employees group and parents group, and the proportion of female was bigger in employees group (P <0.001). There were more pure-GGNs both in employees group and parents group. There were less participants with solitary GGN in employee group than parent group (P = 0.033). Besides, there were more large GGNs (≥10 mm) (P <0.001), LU-RADS 4 GGNs (P <0.001) and LU-RADS 4B GGNs (P = 0.003), LU-RADS 4C-5 GGNs (P = 0.001) in parent group than employee group. There were 36 employee–parent pairs (27.07%) both had GGNs among 133 pairs who both performed LDCT. GGNs in employees were smaller and lower-grade than their parents (P < 0.001, P = 0.001).ConclusionsAmong the employees and parents who had ground glass nodules, 1/4 of them both detected GGNs. Although the detection rate of GGNs in the parent group was lower than that in the employee group, the grade of nodules was significantly higher. All these suggest that the occurrence and development of ground glass nodules may be related to genetic factors.

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“…Technological advancement in medicine has evolved rapidly, with low-dose computed tomography (LDCT) screening, the discovery of multifocal lung cancer, incidental ground-glass opacity (GGO), and early-stage lung cancer becoming increasingly common [1,2]. Incidental GGO can be risk of malignant precursor or early-stage lung malignancy in up to 63% of cases [3][4][5][6], bringing new management challenges especially because of multifocal tendency. Lung resection remains the gold standard for treatment of early-stage nonsmall cell lung carcinoma (NSCLC) [7], however 20% of patients are not suitable for lung resection due to multiple comorbidities and poor cardiopulmonary reserve [8,9].…”

Section: Introductionmentioning

confidence: 99%

Treatment strategies for malignant pulmonary nodule: beyond lobectomy. Point-counterpoint

Chang,

Ng,

Nezami

2023

Current Opinion in Pulmonary Medicine

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Purpose of review Technological advancement in low-dose computed tomography resulted in an increased incidental discovery of early-stage lung cancer and multifocal ground glass opacity. The demand for parenchyma-preserving treatment strategies is greater now than ever. Pulmonary ablative therapy is a groundbreaking technique to offer local ablative treatment in a lung-sparing manner. It has become a promising technique in lung cancer management with its diverse applicability. In this article, we will review the current development of ablative therapy in lung and look into the future of this innovative technique. Recent findings Current literature suggests that ablative therapy offers comparable local disease control to other local therapies and stereotactic body radiation therapy (SBRT), with a low risk of complications. In particular, bronchoscopic microwave ablation (BMWA) has considerably fewer pleural-based complications due to the avoidance of pleural puncture. BMWA can be considered in the multidisciplinary treatment pathway as it allows re-ablation and allows SBRT after BMWA. Summary With the benefits which ablative therapy offers and its ability to incorporate into the multidisciplinary management pathway, we foresee ablative therapy, especially BMWA gaining significance in lung cancer treatment. Future directions on developing novel automated navigation platforms and the latest form of ablative energy would further enhance clinical outcomes for our patients.

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The Epidemiology of Ground Glass Opacity Lung Adenocarcinoma: A Network-Based Cumulative Meta-Analysis

Cited by 11 publications

References 63 publications

The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma

The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma

Characteristics of Ground-Glass Nodules Detected by Low-Dose Computed Tomography as a Regular Health Examination Among Chinese Hospital Employees and Their Parents

Treatment strategies for malignant pulmonary nodule: beyond lobectomy. Point-counterpoint

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