The epidemiology of measles in Poland: prevalence of measles virus antibodies in the population

Janaszek, W; W, Gut; GAY, N. J.

doi:10.1017/s0950268899004616

Cited by 16 publications

(10 citation statements)

References 9 publications

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“…9 In a study from Brazil, only 44% of children aged 9-15 years were antibody positive while a study from Poland observed that measles antibody was below the protective level in 22.5% of children. 24 In our study, measles antibody was detected in 80% children in the 13-24 months age group and 90% children in the 25-36 months age group, which gradually decreased to 62.5% in the 37-84 months age group. However, from the 85-96 months age group it increased again to 75% reaching 86% in the 97-108 months and 80% in 109-120 age groups.…”

Section: Detection Of Measles Iggsupporting

confidence: 47%

Antibody Responses In Bangladeshi Children Following Measles Vaccination.

Sultana

Tabassum

Nessa

et al. 2017

Bangladesh J Med Microbiol

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Abstract:Measles is a highly contagious vaccine preventable viral disease which mainly affects children. Infection with wild measles virus induces an immune response that provides life long protection. Measles has been targeted for global eradication. In Bangladesh, there is insufficient data about the antibody responses in children following measles vaccination. In the present study, the antibody response of a single dose of measles vaccine was investigated among 77 children of different age groups. The humoral immune response immunoglobin IgG (IgG) was detected by a commercial Enzyme-linked Immunosorbent Assay (ELISA). Among the study population, detectable antibody titer was observed in 75.3% children while 24.7% showed detectable titers. The mean antibody concentration was highest (2.75 ± 1.10 IU/ml) in the 13-24 months age group, decreased gradually with age, and was lowest (0.77 ± 0.13 IU/ml) in the 85-96 months age group. Thereafter, the mean antibody concentration gradually increased again in the 97-108 months (1.20 ± 0.13 IU/ml) and in the 109-120 months (1.45 ± 0.13 IU/ml) age groups. The mean antibody titer was statistically significant in relation to age (p<0.01) but not to gender (p<0.95). This study showed that around 25% children remained antibody negative indicating challenges ahead for eradication of measles from Bangladesh.

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Section: Detection Of Measles Iggsupporting

confidence: 47%

Antibody Responses In Bangladeshi Children Following Measles Vaccination.

Sultana

Tabassum

Nessa

et al. 2017

Bangladesh J Med Microbiol

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“…The regression equations were quadratic (13/21), linear (5/21) as well as sigmoid (2). All laboratories using the EIA kit of Dade Behring or DiaSorin showed R 2 values of o0 .…”

Section: Rubella Resultsmentioning

confidence: 96%

“…Serological surveys allow the early identification of susceptible cohorts, allowing targeted interventions, e.g. catch-up campaigns to be undertaken [1][2][3][4]. Serological surveys can also be used to evaluate the impact of campaigns and ascertain elimination status [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Standardization of measles, mumps and rubella assays to enable comparisons of seroprevalence data across 21 European countries and Australia

Tischer

Andrews²,

Kafatos³

et al. 2007

Epidemiol. Infect.

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SUMMARYThe aim of the European Sero-Epidemiology Network is to establish comparability of the serological surveillance of vaccine-preventable diseases in Europe. The designated reference laboratory (RL) for measles, mumps, rubella (MMR) prepared and tested a panel of 151 sera by the reference enzyme immunoassay (rEIA). Laboratories in 21 countries tested the panel for antibodies against MMR using their usual assay (a total of 16 different EIAs) and the results were plotted against the reference results in order to obtain equations for the standardization of national serum surveys. The RL also tested the panel by the plaque neutralization test (PNT). Large differences in qualitative results were found compared to the RL. Well-fitting standardization equations with R 2 o0 . 8 were obtained for almost all laboratories through regression of the quantitative results against those of the RL. When compared to PNT, the rEIA had a sensitivity of 95 . 3%, 92 . 8% and 100 % and a specificity of 100%, 87 . 1 % and 92 . 8 % for measles, mumps and rubella, respectively. The need for standardization was highlighted by substantial inter-country differences. Standardization was successful and the selected standardization equations allowed the conversion of local serological results into common units and enabled direct comparison of seroprevalence data of the participating countries.

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“…Based on the frequency distribution of (log) antibody levels in unvaccinated individuals, we defined as seronegative individuals whose measles-specific IgG antibody level were less than 100 IU/l. Seropositive individuals were stratified by cut-off levels of 255 [4], 500 [7] and 1000 IU/l [9].…”

Section: Classification Of Measles Antibody Statusmentioning

confidence: 99%

“…Serological surveys of specific antibody status in vaccinated populations provide valuable information to health authorities on the impact of the intervention on continued transmission [1,2], the distribution (by age and geographical location) of proportions seronegative [3][4][5], the risks of an outbreak [1,6], and the progress towards elimination [7]. Surveys that report on the level of detectable antibody, rather than presence or absence, may further inform on the likely distribution of sub-clinical, mild and typical measles re-infection and on the potential for community persistence of measles [3,4,[8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination

Enquselassie

Ayele²,

Dejene³

et al. 2003

Epidemiol. Infect.

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We undertook a representative survey of measles antibodies in Addis Ababa, Ethiopia 1994, to characterize immunity and transmission. Specific-antibody levels (IU/l) were determined by ELISA for 4654 sera from individuals aged 0-49 years (1805 <15 years) collected by stratified household-cluster sampling. The proportion seronegative (<100 IU/l) was 20 % (95 % CI : 16-25) in children 9-59 months old, declining to 9 % (7-12) in 5-9 year olds, 5 % (4 -7) in 10-14 year olds, and <1% in adults. The proportion of children (<15 years old) with low-level antibody (100-255 IU/l) was 8% (7-10). Vaccination and an absence of a history of measles illness were strongly associated with low-level antibody. History of measles vaccination in 9 months to 14-year-old children was y80%. We estimate a primary vaccine failure rate of 21 % (12-34) and continued high measles incidence of 22 per 100 susceptibles (19-24) per annum. Our data support the introduction of campaign vaccination in the city in 1998, although higher routine vaccine coverage is required to sustain the impact. The implications of a high prevalence of low-level antibody are discussed.

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The epidemiology of measles in Poland: prevalence of measles virus antibodies in the population

Cited by 16 publications

References 9 publications

Antibody Responses In Bangladeshi Children Following Measles Vaccination.

Antibody Responses In Bangladeshi Children Following Measles Vaccination.

Standardization of measles, mumps and rubella assays to enable comparisons of seroprevalence data across 21 European countries and Australia

Seroepidemiology of measles in Addis Ababa, Ethiopia: implications for control through vaccination

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