The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review

El-Metwally, Ashraf; Toivola, Paivi; Alahmary, Khalid; Bahkali, Salwa; Khathaami, Ali M. Al; Ammar, Shatha A Al; Al-Tamimi, Ibrahim; Alosaimi, Saleh M; Jawed, Muhammad; Almustanyir, Sami

doi:10.1155/2020/4790254

Cited by 48 publications

(46 citation statements)

References 57 publications

(62 reference statements)

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“…In parallel, common genetic polymorphisms at CALCB have been reported to contribute to diverticular disease that is a common of intestinal neuromuscular function 70 . Of note, several epidemiologic studies reported that gastrointestinal disorders such as the “irritable bowel syndrome” are the most commonly reported comorbidities associated with migraine 71 , 72 . Our results suggest that the relationship between the intestine and migraine, also referred to “gut-brain axis,“ could have some genetic origin.…”

Section: Discussionmentioning

confidence: 99%

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

et al. 2021

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Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS1, PBRM1, and SLC25A21) specific to women. This large multiethnic migraine study provides important information that may substantially improve our understanding of the etiology of migraine susceptibility.

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Section: Discussionmentioning

confidence: 99%

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

et al. 2021

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“…In this study, females had a higher prevalence of migraine and IBS than males. This observation has been thoroughly established in the literature pertaining to Arab nations as well as globally [2,13,29,30]. Females showed not only a higher prevalence of migraine and IBS, but also the bivariate and regression analysis demonstrated that females had a higher probability of having migraine and IBS.…”

Section: Discussionmentioning

confidence: 55%

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Abdulrahman¹,

Alenazi²,

Albishri³

et al. 2021

Preprint

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Migraine is a primary headache disorder with a prevalence of 11.6% globally and 27% in Saudi Arabia. Irritable bowel syndrome has a prevalence of 9.2% worldwide. The prevalence of IBS has not been established nationally. However, provincial studies for both migraine and IBS have been conducted across the nation. There is a significant link between migraines and IBS globally. This identifies an association that needs to be investigated in a nationwide manner. This study aims to observe the association and the relationship between migraine and irritable bowel syndrome in Saudi Arabia. A cross-sectional study was conducted between March 2021 to June 2021 among the general population of Saudi Arabia, whose ages are 15 years old or greater. The data collection tools included MS-Q for migraine symptoms, MIGSEV scale for severity of migraine, and The IBS module of the Rome IV Diagnostic Questionnaire (R4DQ) for IBS symptoms and its subtype. With a total of 2802 participants, the majority of the study sample were males, who constituted 52.5%. Among the study's sample, the prevalence of migraine consisted of 27.4%, and the prevalence of IBS was 16.4%. The odds of having IBS in migraineurs were much higher than in those without migraines (OR 4.127; 95% CI 3.325-5.121), and the association was statistically significant (P&lt;0.001). In conclusion, there is a strong association between migraine and irritable bowel syndrome in Saudi Arabia.

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“…In this study, females had a higher prevalence of migraine and IBS than males. This observation has been thoroughly established in the literature about Arab nations and globally [ 2 , 13 , 34 , 35 ]. Females showed a higher prevalence of migraine and IBS, and the bivariate and regression analysis demonstrated that females had a higher probability of having migraine and IBS.…”

Section: Discussionmentioning

confidence: 77%

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey

Abdulrahman

Alenazi

Albishri

et al. 2022

BioMed Research International

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Migraine is a primary headache disorder with a prevalence of 11.6% globally and 27% in Saudi Arabia. Irritable bowel syndrome (IBS) has a prevalence of 9.2% worldwide. The prevalence of IBS has not been established nationally. However, provincial studies for migraine and IBS have been conducted nationwide. There is a significant link between migraine and IBS globally. Migraineurs had a considerably greater prevalence of IBS than nonmigraineurs ( OR = 2.49 , 95% CI 2.22-2.78). Patients with IBS have 60% higher odds for migraines. This identifies an association that needs to be investigated in a nationwide manner. The study has two main aims. The first is to measure the prevalence of migraine and irritable bowel syndrome in Saudi Arabia. The second is to observe the association and the relationship between migraine and irritable bowel syndrome in Saudi Arabia. A cross-sectional study was conducted among the general population of Saudi Arabia between March 2021 and June 2021, whose ages are 15 years old or greater. Participants filled an online self-administered survey. The data collection tools included the Migraine Screen Questionnaire (MS-Q) for migraine symptoms, migraine severity (MIGSEV) scale for severity of migraine, and the IBS module of the Rome IV Diagnostic Questionnaire (R4DQ) for IBS symptoms and their subtype. With 2802 participants, the majority of the study samples were males, who constituted 52.5%. Among the study’s sample, the prevalence of migraine consisted of 27.4%, and the prevalence of IBS was 16.4%. The odds of having IBS in migraineurs were much higher than in those without migraine (OR 4.127; 95% CI 3.325-5.121), and the association was statistically significant ( p < 0.001 ). In conclusion, there is a strong association between migraine and irritable bowel syndrome in Saudi Arabia.

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The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review

Cited by 48 publications

References 57 publications

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey

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