The epidemiology of multicomponent blood transfusion: a systematic review

Perelman, Iris; Khair, Simonne; Dermer, E.; Tinmouth, Alan; Saidenberg, Elianna; Fergusson, Dean

doi:10.1111/tme.12584

Cited by 7 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients undergoing cardiothoracic surgery are at substantial risk for blood transfusion 1‐3 . The benefits of blood transfusions are quickly enhanced oxygen‐carrying capacity and improved hemostasis 1, 4 . However, patients receiving blood transfusion are at risk of the transmission of viral diseases and bacteria, and adverse (immunological) reactions (possibly due to medical errors occurring in blood transfusion practices).…”

Section: Introductionmentioning

confidence: 99%

A prognostic model for the preoperative identification of patients at risk for receiving transfusion of packed red blood cells in cardiac surgery

et al. 2021

View full text Add to dashboard Cite

Background Patients undergoing cardiothoracic surgery are at substantial risk for blood transfusion. Increased awareness and patient blood management have resulted in a significant reduction over the past years. The next step is preoperative treatment of patients at high risk for packed red blood cells (RBC) transfusion, with the ultimate goal to eventually prevent RBC transfusion. A prediction model was developed to select patients at high risk for RBC transfusion. Materials and methods Data of all patients that underwent cardiac surgery in our center between 2008 and 2013 (n = 2951) were used for model development, and between 2014 and 2016 for validation (n = 1136). Only preoperative characteristics were included in a multinomial regression model with three outcome categories (no, RBC, other transfusion). The accuracy of the estimated risks and discriminative ability of the model were assessed. Clinical usefulness was explored. Results Risk factors included are sex, type of surgery, redo surgery, age, height, body mass index, preoperative hemoglobin level, and preoperative platelet count. The model has excellent discriminative ability for predicting RBC transfusion versus no transfusion (area under the curve [AUC] = 94%) and good discriminative ability for RBC transfusion versus other transfusion (AUC = 84%). With a cut‐off value of RBC risk of 16.8% and higher, the model is well able to identify a high proportion of patients at risk for RBC transfusion (sensitivity = 87.1%, specificity = 82.3%). Conclusion In the current study, a prediction tool was developed to be used for risk stratification of patients undergoing elective cardiac surgery at risk for blood transfusions.

show abstract

Section: Introductionmentioning

confidence: 99%

A prognostic model for the preoperative identification of patients at risk for receiving transfusion of packed red blood cells in cardiac surgery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Changes in environmental conditions in modern life, an increase in the number of patients in emergency services, and the appearance of new types of diseases increase the demand for blood, for which there is no substitute [9]. Blood and its derivatives derived from humans are expensive and difficult to obtain; therefore, it is vital to handle these products with more care and avoid their unnecessary use [10,11]. In this study, we studied the indications, therapeutic applications, and problems of blood and its products, which are commonly used by emergency services.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Evaluation of Blood Product Transfusions Administered in the Emergency Department

Seçkin¹,

Coşkun²,

Demirci³

et al. 2023

globecc

View full text Add to dashboard Cite

Objective: It was aimed to evaluate the clinical and laboratory findings, the frequency and distribution of post-transfusion complications of patients who presented to the emergency department with a transfusion indication. Materials and Methods:In our study, patients aged 18 years and over who applied to the emergency medicine clinic between January 01, 2019 and March 31, 2019, who had blood and blood product transfusions, were retrospectively analyzed. The demographic and clinical characteristics of the patients, the reason for transfusion, the number of transfused blood products, the presence and type of complications were analyzed.Results: Three hundred and sixty-eight patients who received blood and blood product transfusions were included in the study. The mean age of the patients was 62.5±19.3 years (range 18-96 years), 193 (52.4%) were female and 175 (47.6%) were male. The most common causes of transfusion were symptomatic anemia in 110 patients (29.9%), oncological diseases in 71 patients (19.3%), gastrointestinal bleeding in 65 patients (17.7%), and chronic renal failure patients in 59 (16%) patients. No post-transfusion complication was observed in 358 (97.3%) patients for all blood products. Multiple erythrocyte suspension (ES) data revealed significant variation in hemoglobin and hematocrit levels among patients (p=0.001). Additionally, a significant difference was found in the international normalized ratio because of administering more than one unit of fresh frozen plasma (FFP) (p=0.002). Complications were observed in 2.9% of patients given ES and 1.9% of patients given FFP, whereas none of the patients given thrombocyte suspension developed. Conclusion:The appropriate use of blood and blood products in the emergency department plays a critical role in preventing patient morbidity and mortality. Performing the transfusion procedure in the correct indication is important in preventing the risk of infection in the emergency department.

show abstract

“…This is an important finding because administration of both red cells and platelets represents the most common co-transfusion. 21 Storage of allogeneic platelet concentrates is limited to 5 to 7 days at room temperature. 22 Therefore, maintaining hospital platelet concentrate inventory is logistically difficult and highly resource-intensive.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Washing Efficiency and Recovery of Blood Cells Between Centrifugation, Coarse Filtration and Microfiltration Techniques to Prepare Autologous Blood for Transfusion

Amenge¹,

Scherphof²,

Osemwengie³

et al. 2022

JBM

View full text Add to dashboard Cite

Purpose Cell salvage is the process by which blood lost in surgery is collected and washed or filtered to produce autologous blood for re-transfusion to the patient. Cell salvage aims to reduce the need for donor blood. Centrifugal cell salvage washing technique is a preferred medical treatment in order to retain lost red blood cells (RBCs) without contaminants. Although this technology very efficiently collects and washes shed blood, it is costly and often impractical or unavailable, especially in middle- or low-income countries. This study assessed two innovative filter devices as an alternative to centrifugal cell salvage technology: a coarse collection filter device (Hemafuse) and a microfiltration device (HemoClear). In contrast to centrifugal technology, both filter devices do not require electricity, nor costly equipment and extensive training. We compared the effectiveness of these filtration technologies to remove plasma constituents and recover and concentrate the cellular components with centrifugal technology (autoLog ® device). Methods Whole blood was processed with each technology according to the device manufacturer’s instructions. Before and after processing, the blood products were analyzed for supernatant solutes and cellular composition. Results The centrifugal technology confirmed its efficacy to remove potentially harmful solutes and capture red blood cells. The microfiltration technology (HemoClear) reached comparable levels of removal of solutes, with a potential advantage over centrifugal technology in the ability to also recover platelets. The coarse filtration technology (Hemafuse) had no washing capacity but, like the microfiltration technology, has the advantage of recovering platelets. Conclusion Innovative filtration devices represent an alternative to centrifugal technology in the preparation of autologous blood for reinfusion. The HemoClear technology for the first time enables the recovery of washed platelets and red blood cells. Clinical trials will have to be performed to investigate the clinical value of this new autologous blood product.

show abstract

The epidemiology of multicomponent blood transfusion: a systematic review

Cited by 7 publications

References 30 publications

A prognostic model for the preoperative identification of patients at risk for receiving transfusion of packed red blood cells in cardiac surgery

A prognostic model for the preoperative identification of patients at risk for receiving transfusion of packed red blood cells in cardiac surgery

Comprehensive Evaluation of Blood Product Transfusions Administered in the Emergency Department

Comparison of Washing Efficiency and Recovery of Blood Cells Between Centrifugation, Coarse Filtration and Microfiltration Techniques to Prepare Autologous Blood for Transfusion

Contact Info

Product

Resources

About