The epidemiology of osteoarthritis

Objectives: Osteoarthritis (OA) is a leading cause of disability, but the relationship with premature mortality remains uncertain. We aimed to investigate the relationship between OA and mortality from any cause and from cardiovascular disease (CVD).Methods: Electronic literature databases searches were conducted to identify prospective studies comparing mortality in a sample of people with and without OA.Risk of call-cause and CVD-mortality were summarized using adjusted hazard ratios (HRs) for joint-specific (hand, hip and knee) and joint non-specific OA. New data from the Progetto Veneto Anziani (PRO.V.A.) study were also included.Results: From the PRO.V.A. study (N=2,927), there was no significant increase in CVD mortality risk for participants with any-joint OA (N=1,858) compared to non-OA (all-cause, HR=0.95; 95% CI: 0.77-1.15; CVD, HR=1.12; 95% CI: 0.82-1.54).On meta-analysis, seven studies (OA: 10,018/non-OA: 18,541), with a median 12-year follow-up, reported no increased risk of any-cause mortality in those with OA (HR=1.10; 95% CI: 0.97-1.25). After removing data on hand OA, a significant association between OA and mortality was observed (HR=1.18; 95% CI: 1.08-1.28).There was a significant higher risk of overall mortality for (1) studies conducted in Europe, (2) patients with multi-joint OA; and (3) a radiological diagnosis of OA. OA was associated with significantly higher CVD mortality (HR=1.21; 95% CI: 1.10-1.34). CVD is potentially preventable through appropriate timely pharmacological and non-pharmacological interventions 10 Therefore, to identify people at higher risk of CVD mortality could be of considerable public health importance.Within the past decade, a number of observational studies have reported that people with OA are at increased risk of premature mortality compared to the general population. [11][12][13] However, this evidence is heterogeneous and limited by the lack of adjustment for appropriate confounders.Given this, the purpose of this study was to: i) analyze data from a prospective cohort study on the risk of CVD mortality in OA compared to a non-osteoarthritis cohort, adjusting for important medical morbidities and other confounders; ii) to systematically review the available literature and perform a meta-analysis to 7 determine whether people with OA present a differential risk of overall and CVD mortality than those without OA. We hypothesized that people with OA had a significant higher risk of overall and CVD death compared to those without OA. 8 MATERIALS AND METHODS Prospective cohort study Overall cohortPreviously unpublished data from the Progetto Veneto Anziani (PRO.V.A. study)were used to investigate the risk of overall and CVD mortality in people with OA over a mean follow-up of 4.4 years. The Pro.V.A. study is an observational cohort study on the Italian population aged over 65 years. The study population initially included 3,099 older Caucasian adults (1,245 men/1,854 women), who were randomly selected between 1995 and 1997 using a multistage stratified met...

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“…8,39,43 In the PRO.V.A. study, people with OA reported a higher presence of frailty, cardiovascular and metabolic diseases than those without.…”

Section: Discussionmentioning

confidence: 99%

Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis

Veronese

Cereda

Maggi

et al. 2016

Seminars in Arthritis and Rheumatism

157

102

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“…골관절염으로 인해 관절의 통증, 뻣뻣함, 관절 주위 근육의 약화가 초래되고, 무릎관절과 고관절이 손상되어 점차 노인의 기동 성 장애의 주요 원인이 된다 [6]. 골관절염은 만성질환으로써 근본적 인 치료가 어렵기 때문에 최선의 자기 관리를 통해 삶의 질을 누리 는 것이 중요하다 [7].…”

Section: %는 골관절염으로 인한 활동제한 상태를 가진 것으로 보고되unclassified

The Effectiveness of Community-based Muscle and Joint Self Management Program for Older Adults

Jeong¹,

Park²,

Hun³

et al. 2017

jkbns

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Purpose: The aim of this study was to determine the effectiveness of a community-based muscle and joint self-management program with muscle stretching and muscle strengthening exercises for community-dwelling older adults. Methods: The study was a pre-and-post design in a single group, which examined the effects after the intervention of muscle and joint self-management program for 6 weeks, on the 42 subjects of the elderly who registered in a Community Senior Center in J city. Data analyses were conducted with paired t-test by using a SAS (version 9.2 for Windows) program. Results: The effectiveness of muscle and joint self-management program on shoulder flexibility and right knee extension (flexibility) were significantly improved (t= 2.72, p= .010; t= -2.26, p= .029). Joint symptoms (pain, stiffness), physical functioning, depression, fatigue, and left knee extension were not significantly improved after the muscle and joint self-management program. Conclusion: The results showed the possibility of this 6-week exercise program in improving shoulder and knee flexibility for community-dwelling older adults. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…That is, the bulk of the research on osteoarthritis research reveals a consistent picture of potentially debilitating overlapping symptoms, including a low sense of morale, social isolation, helplessness, further depression, anxiety, sleep disturbances, and disability that can heighten and prolong the osteoarthritic pain experience with few comprehensive treatment options [50] and that fostering a positive, rather than ignoring any negative affect, may help to attenuate the prevailing degree of osteoarthritic pain and disability [51]. In light of the growing prevalence of this disease and the highly resistant nature of chronic non-malignant osteoarthritic pain to intervention, where only about 50 percent of cases may report adequate relief from traditional treatments, unravelling this cycle of deleterious events and examining what specific interventions may prove beneficial to the individual patient with this condition appears paramount [52,53]. Unfortunately, even though more than 80% of this population may be in constant pain and have difficulty in accomplishing everyday tasks, current treatment approaches often fail to provide adequate relief, and clearly do not commonly intervene to break the cycle of suffering [54].…”

Section: Depression and Osteoarthritis Painmentioning

confidence: 99%

“…As well, functional disability, common in older adults, and associated with a high risk of subsequent decline is likely to impacted adversely by depression, as is pain and life satisfaction [58,59]. Thirdly, patients with hip or knee osteoarthritis who exhibited preoperative depressive symptoms had worse patient reported outcomes 3 and 12 months after surgery and were less satisfied than those with no depressive symptoms and depression may be associated with weight gain, which is a risk factor for more adverse osteoarthritis outcomes [52,60,61].…”

Section: Need For Interventions To Decrease Depressionmentioning

confidence: 99%

Depression and Osteoarthritis: Impact on Disability

Marks¹

2014

Aging Sci

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Osteoarthritis, a highly prevalent progressively disabling chronic health condition associated with aging, is frequently addressed from a physical standpoint, rather than a more holistic standpoint, even though psychological correlates are often prevalent co morbid determinants of this condition. This review briefly summarizes the literature on osteoarthritis and depression published over the last 30 years. From this review, it is concluded that depression is a frequent correlate of osteoarthritis disability, and where present heightens the prevailing disabling painful experience consistently and significantly. Since depression is amenable to treatment, it is recommended more attention to routinely screening for depression among osteoarthritis sufferers, rather than doing this sporadically, is strongly indicated for promoting optimal outcomes among this burgeoning population.

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The epidemiology of osteoarthritis

Cited by 841 publications

References 80 publications

Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis

Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis

The Effectiveness of Community-based Muscle and Joint Self Management Program for Older Adults

Depression and Osteoarthritis: Impact on Disability

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