The Epidemiology of Psychosis in Dementia

Leroi, Iracema; Voulgari, Argyro; Breitner, John C.S.; Lyketsos, Constantine G.

doi:10.1097/00019442-200301000-00011

Cited by 95 publications

(50 citation statements)

References 34 publications

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“…25 We found an association between low education and psychotic symptoms in AD but not in VaD which is in line with 2 clinical studies. 30,31 However most clinical studies 4,5 and 1 population-based study 25 have not found this association. It must be remembered that all previous studies are based on mixed ages.…”

Section: Discussionsupporting

confidence: 90%

“…25 Our lack of associations between psychotic symptoms and duration of dementia is in line with the findings from clinical 4,5 and 1 population-based study. 25 We found an association between low education and psychotic symptoms in AD but not in VaD which is in line with 2 clinical studies. 30,31 However most clinical studies 4,5 and 1 population-based study 25 have not found this association.…”

Section: Discussionsupporting

confidence: 87%

“…Psychotic symptoms were related to dementia severity in AD which is in line with 1 previous population-based study. 25 The latter showed an association between delusions and increased severity of AD according to the Clinical Dementia Rating scale. 26 According to DSM-III-R criteria, 21 the severity of dementia is measured as impairment in social activities and activities of daily living.…”

Section: Discussionmentioning

confidence: 96%

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Psychotic Symptoms in a Population-Based Sample of 85-Year-Old Individuals With Dementia

Östling

Gustafson

Blennow

et al. 2010

J Geriatr Psychiatry Neurol

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Psychotic symptoms are common in elderly persons with dementia. These symptoms affect a person's ability to function in daily life and put strain on the caregiver. Most studies focus on psychotic symptoms in clinical samples with Alzheimer disease (AD). Thus, their prevalence and relation with dementia subtype and severity in very old populations is unclear. We assessed a representative sample of 85-year-old individuals living in Gothenburg, Sweden (n = 494) using neuropsychiatric examinations, key informant interviews, and medical record reviews; 147 had dementia. Dementia and its severity were diagnosed in accordance with Diagnostic and Statistical Manual of Mental Disorders (Third Edition, Revision [DSM-III-R]) criteria. Alzheimer disease according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria was diagnosed in 64 persons and vascular dementia (VaD) according to Erkinjuntti criteria was observed in 69. Fourteen had dementia due to other causes. Psychotic symptoms were classified according to DSM-III-R. The prevalence of psychotic symptoms in this very old population was 36% among AD cases compared to 54% in VaD cases (P = .04). Proportions with psychotic symptoms increased with increasing dementia severity in individuals with AD. No such association could be shown in those with VaD. This finding of a high proportion of psychotic symptoms also in individuals with mild severity of VaD should alert health professionals to evaluate dementia in very old patients who present with hallucinations or delusions.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Psychotic Symptoms in a Population-Based Sample of 85-Year-Old Individuals With Dementia

Östling

Gustafson

Blennow

et al. 2010

J Geriatr Psychiatry Neurol

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“…The evidence for female gender as a risk factor for psychosis in AD has been equivocal. 33,34 Although Spanish speakers sought a diagnosis and intervention later in the course of AD than English speakers, the free memory screening program was an effective method for facilitating earlier diagnosis of AD in both groups. Among Hispanics, delays in the diagnosis and treatment of cognitive impairment are partly due to an underutilization of mental health services 35 and have been attributed to personal and cultural beliefs, lack of proficiency in the English language, and economic status.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Memory Screening Program on the Early Diagnosis of Alzheimer Disease

Barker¹,

Luis²,

Harwood³

et al. 2005

Alzheimer Disease &Amp; Associated Disorders

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“…With the high prevalence of behavior disorders among patients with highly progressed dementia, 24 it seemed reasonable to record study participants' treatment with antipsychotic medication. Because treatment with antipsychotics is a risk factor for mortality, 25 as little medication as possible should be used in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Treatment Characteristics of Patients With Dementia: Comparing Two Different Psychiatric Inpatient Settings

Haude

Lüdeke

Dohse

et al. 2009

Am J Alzheimers Dis Other Demen

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The Epidemiology of Psychosis in Dementia

Cited by 95 publications

References 34 publications

Psychotic Symptoms in a Population-Based Sample of 85-Year-Old Individuals With Dementia

Psychotic Symptoms in a Population-Based Sample of 85-Year-Old Individuals With Dementia

The Effect of a Memory Screening Program on the Early Diagnosis of Alzheimer Disease

Treatment Characteristics of Patients With Dementia: Comparing Two Different Psychiatric Inpatient Settings

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