The Epidemiology of Rotavirus Diarrhea in Countries in the Eastern Mediterranean Region

Malek, M. A.; Teleb, Nadia; Abu‐Elyazeed, Remon; Riddle, Mark S.; Sherif, May El; Steele, A. Duncan; Glass, Roger I.; Bresee, Joseph S.

doi:10.1086/653579

Cited by 49 publications

(51 citation statements)

References 43 publications

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“…As previously observed in the Eastern Mediterranean region [18][19][20][21] and Europe, 22 we found the burden of RVGE to be the highest in children younger than 2 y. More specifically, RVGE was found predominantly in the 7-12 mo age group in a study conducted in 1994 in UAE (34.8%).…”

Section: Discussionsupporting

confidence: 83%

Burden and genotyping of rotavirus disease in the United Arab Emirates

Howidi

Balhaj

Yaseen

et al. 2014

Human Vaccines & Immunotherapeutics

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Section: Discussionsupporting

confidence: 83%

Burden and genotyping of rotavirus disease in the United Arab Emirates

Howidi

Balhaj

Yaseen

et al. 2014

Human Vaccines & Immunotherapeutics

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“…In the present study, children hospitalized for diarrhoea were more likely to have RVA detected (24.9 %) than those consulting as outpatients (18.5 %), confirming that RVA gastroenteritis is usually more severe than non-RVA diarrhoea (El-Shabrawi et al, 2015; Malek et al, 2010).…”

Section: Rva Detection Ratesupporting

confidence: 78%

Distribution of rotavirus VP7 and VP4 genotypes circulating in Tunisia from 2009 to 2014: Emergence of the genotype G12

Moussa

Fredj

Fodha

et al. 2016

Journal of Medical Microbiology

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Group A rotavirus (RVA) represents the most important aetiological agent of diarrhoea in children worldwide. From January 2009 to December 2014, a multi-centre study realized through 11 Tunisian cities was undertaken among children aged <5 years consulting or hospitalized for acute gastroenteritis. A total of 1127 faecal samples were collected. All samples were screened by ELISA for the presence of RVA antigen. RVA-positive samples were further analyzed by PAGE and used for G/P-genotyping by semi-nested multiplex RT-PCR. Globally, 270 specimens (24 %) were RVA-positive, with peaks observed annually between November and March. Nine different electropherotypes could be visualized by PAGE, six with a long profile (173 cases) and two with a short one (seven cases). Mixed profiles were detected in two cases. Among the 267 VP7 genotyped strains, the predominant G-genotype was G1 (39.6 %) followed by G3 (22.2 %), G4 (13 %), G9 (11.5 %), G2 (5.2 %) and G12 (5.2 %). Among the 260 VP4 genotyped strains, P[8] genotype was the predominant (74. 9 %). Uncommon G/Pgenotype combinations, mixed infections and untypeable strains were also detected. This is the first report, in Tunisia, of multiple detection of an emerging human RVA strain, G12 genotype. This study highlighted the need for maintaining active surveillance of emerging strains in Northern Africa.

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“…The detection rate of rotavirus is 40% in the eastern Mediterranean region, while a higher level was found in Asia with 45% and lower in Latin America and Africa with 38% and 24% respectively. [16][17][18] This was consistent to the studies by Parasher et al 5 A much higher rate compared to our study was reported by Taqbo et al of 56% rotaviral incidence in children below 5 years of age. 9 In India, an incidence of 34% was reported in various studies.…”

Section: Discussionsupporting

confidence: 93%