The epidemiology of sepsis in a Brazilian teaching hospital

Kauss, Ivanil A.M.; Grion, Cintia Mc; Cardoso, Lucienne Tibery Queiroz; Anami, Elza Hiromi Tokushima; Nunes, Liane Brescovici; Ferreira, GL; Matsuo, Tiemi; Bonametti, Ana Maria

doi:10.1016/s1413-8670(10)70054-4

Cited by 28 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement with a recent epidemiological study in a Brazilian hospital in the state of Paraná, we found that the main medical cause for ICU admission was sepsis (35% against 40% in Kauss et al 29 recent study), and the mortality rates at ICU plus follow-up were 46% in our study compared to 42% in Kauss et al 29 Our study revealed no association between -308G > A TNF-α genotypes and adverse outcomes (sepsis, septic shock, higher organ dysfunction or mortality) from critical illness. Our results demonstrated that the -308A rare allele frequency was 15%, confirming the trend documented in Danish (22%), 24 English (20%), 23 French (18%), 17 and Spanish subjects (9%).…”

Section: Discussionsupporting

confidence: 93%

TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness

Paskulin¹,

Fallavena²,

Paludo³

et al. 2011

Braz J Infect Dis

View full text Add to dashboard Cite

Background:The susceptibility to adverse outcome from critical illness (occurrence of sepsis, septic shock, organ dysfunction/failure, and mortality) varies dramatically due to different degrees of inflammatory response. An over expression of tumor necrosis factor alpha (TNF-α) can lead to the progression of the inflammatory condition. Objective: We assessed the relationship of the genotype distribution of -308G >A TNF-α polymorphism with regard to the development of sepsis, septic shock, higher organ dysfunction or mortality in critically ill patients. Methods: Observational, hospital-based cohort study of 520 critically ill Caucasian patients from southern Brazil admitted to the general ICU of São Lucas Hospital, Porto Alegre, Brazil. Patients were monitored daily from the ICU admission day to hospital discharge or death, measuring SOFA score, sepsis, and septic shock occurrences. The -308G >A TNF-α SNP effect was analyzed in the entire patient group, in patients with sepsis (349/520), and in those who developed septic shock (248/520). Results: The genotypic and allelic frequencies were -308GG = 0.72; -308GA = 0.27; -308AA = 0.01; -308G = 0.85; -308A = 0.15. No associations were found with sepsis, septic shock, organ dysfunction, and/or mortality rates among the TNF-α genotypes. Our results reveal that the -308G >A TNF-α SNP alone was not predictive of severe outcomes in critically ill patients. Conclusion: The principal novel input of this study was the larger sample size in an investigation with -308G > A TNF-α SNP. The presence of -308A allele is not associated with sepsis, septic shock, higher organ dysfunction or mortality in critically ill patients.

show abstract

Section: Discussionsupporting

confidence: 93%

TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness

Paskulin¹,

Fallavena²,

Paludo³

et al. 2011

Braz J Infect Dis

View full text Add to dashboard Cite

show abstract

“…Es la principal causa de mortalidad en pacientes críticamente enfermos no coronarios con una tasa entre 19,6 y 59% 2,3 . La mortalidad es atribuida a la falla de diferentes órga-nos, entre los cuales el sistema cardiovascular es objeto de interés 4 .…”

Section: Introductionunclassified

Estudio ECAIS: eventos cardiovasculares adversos inadvertidos en sepsis

Duque¹,

Olivera²,

Torres³

et al. 2012

Medicina Intensiva

View full text Add to dashboard Cite

PALABRAS CLAVEIsquemia miocárdica; Electrocardiografía ambulatoria; Sepsis; Choque séptico Resumen Objetivo: Describir la incidencia de eventos cardiovasculares adversos en pacientes con diagnóstico de sepsis en sus diferentes estadios. Diseño: Estudio observacional, descriptivo, longitudinal. Ámbito: Unidades de cuidados intensivos de tipo mixto de dos hospitales universitarios en la ciudad de Bogotá. Participantes: Se incluyeron una serie de pacientes mayores de edad, que ingresan a UCI con diagnostico de sepsis, sin evidencia de lesión miocárdica isquémica previa. Intervenciones: Registros electrocardiográficos continuos de 12 derivaciones durante 48 horas con monitoría Holter Variables de interés: Isquemia, arritmia cardiaca, variabilidad de la frecuencia cardiaca. Resultados: Se analizaron 100 pacientes, 62% de los cuales se estadificó como choque sép-tico. El 3% presentó evento cardiovascular adverso de tipo isquémico detectado por Holter y desapercibido por monitoreo convencional. El 46% presentaron un evento de tipo arrít-mico por Holter, comparado con solo un 6% detectado por monitoreo convencional. La mortalidad cruda fue de 40%. El 100% presentó pérdida de la variabilidad de la frecuencia cardiaca. Conclusión: La sepsis en esta experiencia mostró una baja incidencia de eventos cardiovasculares isquémicos. Los eventos arrítmicos, sin embargo, mostraron una incidencia alta. El monitoreo convencional falló en detectar la totalidad de los eventos isquémicos y en mayor proporción los eventos arrítmicos. En esta serie, los eventos cardiovasculares generados por descarga adrenérgica no impactan en la mortalidad.

show abstract

“…These findings have been already described and indicate the importance of studying sepsis diagnoses and their effect on nursing activities in the ICU. [22] The increased workload during the first week most likely reflects the application of the early care measures recommended by the international guidelines for patients with sepsis and the measures taken to prevent and treat the organ dysfunctions that commonly occur among these patients at the onset of treatment. [3] Recent study found that excessive nursing workload was the most important risk factor for acquiring nosocomial infection.…”

Section: Discussionmentioning

confidence: 99%

Increased nursing workload in patients with sepsis: A cohort study

Altafin

Grion

Kauss

et al. 2015

Clinical Nursing Studies

View full text Add to dashboard Cite

Objective: To assess the nursing workload using the Nursing Activities Score (NAS) and compare results between patients with and without sepsis at an adult intensive care unit. Methods: Prospective cohort study of patients admitted to the adult intensive care unit from March 10 to December 31, 2008. Clinical data of septic patients were collected in addition to data needed to calculate scores. Data were collected each day until release from the intensive care unit or up to 90 days of hospitalization. The nursing workload assessed using the Therapeutic Intervention Score System-28 and Nursing Activities Score relative to patients with and without sepsis were compared. The significance level was established at 5%. Results: A total of 437 patients were assessed (318 with and 119 without sepsis). The average nursing workload as measured by the Nursing Activities Score was high for the general intensive care unit (Nursing Activities Score = 74.7%). Patients with sepsis were associated with greater nursing workloads during their first two weeks in the intensive care unit compared with patients without sepsis (p < .05). Patients with septic shock were associated with greater nursing workloads (median Nursing Activities Score = 75.62%, p < .001) compared with patients without sepsis (median Nursing Activities Score = 72.57%), those with sepsis (median Nursing Activities Score = 70.20%), and those with severe sepsis (median Nursing Activities Score = 72.65%). Conclusions: Sepsis increased nursing workload during the first two weeks after admission to the intensive care unit and the NAS may be useful to capture these differences.

show abstract

The epidemiology of sepsis in a Brazilian teaching hospital

Abstract: The data from our study revealed a high incidence of sepsis among hospitalized patients. Moreover, sepsis patients had a high rate of mortality.

Cited by 28 publications

References 35 publications

TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness

TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness

Estudio ECAIS: eventos cardiovasculares adversos inadvertidos en sepsis

Increased nursing workload in patients with sepsis: A cohort study

Contact Info

Product

Resources

About