The Epidemiology of Stomach Cancer

Hirayama, T

doi:10.36255/exon-publications-gastrointestinal-cancers-stomach-cancer-epidemiology

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…Gastric cancer (GC), the third leading cause of cancer-related mortality in Japan (1), presents a substantial clinical challenge, particularly in advanced stages, where the prognosis markedly worsens (2). The complexity of GC pathogenesis is further compounded by the pivotal role of cancer stem cells (CSCs) (3), which drive tumor progression, metastasis, and therapeutic resistance (4).…”

Section: Introductionmentioning

confidence: 99%

Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer

Ishikawa,

Fukui,

Kido

et al. 2024

Preprint

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Background: Gastric cancer (GC) is characterized by significant intratumoral heterogeneity and stem cells presenting as promising therapeutic targets. Despite advancements in spatial transcriptome analysis, unexplored targets for addressing cancer stemness remain unknown. This study aims to identify Nuclear Factor IX (NFIX) as a critical regulator of cancer stemness in GC and evaluate its clinicopathological significance and function. Methods: Spatial transcriptome analysis was conducted on GC. NFIX expression′s correlation with clinicopathological factors and prognosis was assessed through immunostaining in 127 GC cases. Functional analyses in cancer cell lines validated these findings. Results: Spatial transcriptome analysis stratified GC tissues based on genetic profiles, pinpointing CSC-like cells and further refined the classification to identify and highlight the NFIX′s significance, validated by Monocle 3 and CytoTRACE analyses. Knockdown experiments in cancer cell lines demonstrated the involvement of NFIX in cancer cell proliferation and kinase activity. Conclusions: This study underscores spatial transcriptome analysis′s role in refining GC tissue classification and identifying therapeutic targets, highlighting NFIX as pivotal. NFIX expression correlates with poor prognosis and drives GC progression, suggesting its potential as a novel therapeutic target for personalized GC therapies.

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Section: Introductionmentioning

confidence: 99%

Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer

Ishikawa,

Fukui,

Kido

et al. 2024

Preprint

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“…Gastric cancer is the fth most prevalent cancer globally [1], with the highest prevalence in Asia, followed by Eastern Europe and Latin Americas [2]. Male sex and older age are established risk factors of gastric cancer, while other factors include tobacco and alcohol use, H. pylori infection, consumption of some Asian-style salt-preserved foods, and being overweight/obese [3][4][5][6]. After initial successes in reducing gastric cancer rates in the second half of the past century, recent studies are raising concerns as they are now increasing among young adults (< 50 years) globally [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Adding salt to food as an indicator of gastric cancer risk among adults: A prospective study

Gicevic,

Thompson,

Gaggl

et al. 2024

Preprint

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Background: While dietary salt intake has been linked with gastric cancer risk in Asian studies, findings from Western populations are sparse and limited to case-control studies. Methods: We evaluated associations between the frequency of adding salt to food and the risk of gastric cancer in a large prospective cohort of UK adults, the UK Biobank (N=471,144). Frequency of adding salt to food was obtained from a touchscreen questionnaire completed by participants at baseline (2006-2010). 24-h urinary sodium excretion was estimated using INTERSALT formulae. Cancer incidence was obtained by linkage to national cancer registries. Results: During the median 10.9 years of follow-up, 640 gastric cancer cases were recorded. In multivariable models, participants reporting adding salt to food “always” had a 41% higher risk of gastric cancer compared to participants who reported adding salt to food “never/rarely” (95%CI: +4%, +91%). There was a positive graded association between the frequency of adding salt to food and estimated 24-h urinary sodium. On the other hand, associations of estimated 24-h urinary sodium with gastric cancer were nonsignificant. Conclusions: “Always adding salt to food” was associated with a higher gastric cancer risk in a large sample of UK adults participating in the UK Biobank study compared to “never/rarely” adding salt to food. Frequency of adding salt to food can serve as a useful indicator of salt intake for surveillance purposes and a basis for devising easy-to-understand public health messages. Mini-abstract High frequency of adding salt to food was associated with a higher risk of gastric cancer among UK adults independent of age, sex, ethnicity, tobacco and alcohol use, prevalent morbidity, diet, or BMI. This is the first prospective study to show that frequently adding salt to food is related to higher gastric cancer risk in a western population. “Always adding salt to food” can serve as a simple indicator of excessive sodium intake for surveillance purposes and a basis for formulating public health messages aimed at gastric cancer prevention.

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“…Gastric cancer (GC) remains to be a common health challenge worldwide despite recent improvements in incidence and mortality rates [1]. Moreover, it is the third leading cause of death in Japan [2].…”

Section: Introductionmentioning

confidence: 99%

Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition

Ishikawa,

Yasumatsu,

Fukui

et al. 2023

Oncology

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Introduction: Gastric cancer (GC) remains a common health concern worldwide and is the third leading cause of death in Japan. It can be broadly classified into gastric and intestinal mucin phenotypes using immunohistochemistry. We previously reported numerous associations of kinesin family member (KIF) genes and mucin phenotypes with GC. However, no previous studies have reported on the importance of KIF18B in GC using immunostaining. Thus, in this study, we investigated the expression and functions of KIF18B, which is highly expressed in gastric mucin phenotype GC. Methods: We performed RNA-seq of gastric and intestinal mucin type GCs, and clinicopathological studies of the KIF18B we found were performed using 96 gastric cancer cases. We also performed functional analysis using GC-derived cell lines. Result: RNA-seq showed the upregulation of matrisome-associated genes in gastric mucin-phenotype GC and a high expression of KIF18B. KIF18B was detected in 52 of the 96 GC cases (54%) through immunohistochemistry. Low KIF18B expression was significantly associated with poor overall survival (P < 0.01). Other molecules that were significantly associated with KIF18B were MUC5AC and claudin 18; these were also significantly associated with the gastric mucin phenotype. KIF18B small interfering RNA (siRNA)-transfected GC cells showed greater growth and spheroid colony formation than the negative control siRNA-transfected cells. Furthermore, expression of snail family transcriptional repressor 1 and cadherin 2 was significantly increased and that of cadherin 1 was significantly decreased in KIF18B siRNA-transfected GC cells. Discussion/Conclusion: These findings not only suggest that KIF18B may be a useful prognostic marker, but also provide insight into the pathogenesis of the GC phenotype.

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The Epidemiology of Stomach Cancer

Cited by 12 publications

References 9 publications

Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer

Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer

Adding salt to food as an indicator of gastric cancer risk among adults: A prospective study

Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition

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