The Epidemiology of the Metabolic Syndrome and its Association with Diabetes, Cardiovascular Disease and Other Conditions

Byrne, Christopher D.

doi:10.1002/9781444347319.ch1

Cited by 3 publications

(1 citation statement)

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“…MS prevalence was around 10-84% based on age, gender, race, ethnicity, and MS criteria [1]. The World Health Organization, International Diabetes Federation, and National Cholesterol of Adult Treatment Panel III have determined specific criteria of MS which included central obesity, high blood pressure, high triglyceride (TG) levels, low high-density lipoprotein (HDL), and high glucose levels [2].…”

Section: Introductionmentioning

confidence: 99%

Light-Roasted Green Coffee Extract Improved Adiponectin, Insulin Resistance, and Metabolic Profile of Metabolic Syndrome Rat Model

Lukitasari

Nugroho

Rohman

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to investigate the effect of light-roasted green coffee bean extract (GCE) administration for 7 weeks on the improvement of metabolic profile, adiponectin level, homeostatic model assessment insulin resistance (HOMA-IR) index in metabolic syndrome (MS) rat model. Methods:Adult male Sprague-Dawley rats were induced by a combination of high sucrose and high-fat diet for 8 weeks and streptozotocin injection in the 2 nd week. The MS was confirmed by NCEP-ATP III criteria. They were divided into six weight-matched groups (n=5), normal control, MS, metformin and simvastatin-treated group (DMS), 100 and 200/body weight (bw) GCE (GCE 100 and GCE 200, respectively). The extracts were given through oral gavage daily for 7 weeks. The effect of GCE on body weight, serum glucose, triglyceride, (TG) and high-density lipoprotein (HDL) level was analyzed by colorimetric method. HOMA-IR index and adiponectin were analyzed by enzyme-linked immunosorbent assay methods.Result: Fasting blood glucose, TG, and systolic blood pressure decreased significantly (p<0.05) in both GCE groups. Moreover, after 7 weeks, those parameters were significantly lower (p<0.05) compared to that of MS group. Only GCE 100 group that showed a significant decrease in HDL level. GCE 100 mg/bw and 200 mg/bw group showed significantly higher adiponectin level compared to that of MS and DMS group. Furthermore, GCE 100, GCE 200, and DMS group showed a significant lower HOMA-IR index compared to that of MS group. Conclusion: 7 weeks GCE administration could decrease fasting blood glucose, profile lipid, blood pressure, and improved adiponectin level and HOMA-IR index.

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Section: Introductionmentioning

confidence: 99%