The Epidermal Vitamin D System and Innate Immunity: Some More Light Shed on This Unique Photoendocrine System?

Segaert, Siegfried; Simonart, Thierry

doi:10.1159/000118506

Cited by 12 publications

(12 citation statements)

References 62 publications

(62 reference statements)

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“…It is possible that the 1,25D-induced CAMP expression may contribute to aggravation of Rosacea caused by exposure to UV light. It has been noted that azole antimycotics (ketoconazole, itraconazole, metronidazole), used in dermatology as antifungal agents in treatment of inflammatory conditions such as rosacea, also block cytochrome P450-driven vitamin D metabolism [62].…”

Section: Regulation Of Camp Expression Under Physiological and Pathopmentioning

confidence: 99%

Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

White

2010

The Journal of Steroid Biochemistry and Molecular Biology

174

131

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Section: Regulation Of Camp Expression Under Physiological and Pathopmentioning

confidence: 99%

Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

White

2010

The Journal of Steroid Biochemistry and Molecular Biology

174

131

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“…Some patients receiving EGFR-targeted agents have been reported to show widespread erythema, infiltration and pustules in sun-exposed areas 19,53,54. One randomized study, N05C4, conducted in the US by NCCTG, has investigated the prophylactic use of SPF60 sunscreen in cancer patients receiving an EGFR-targeted agent as part of their therapy 39…”

Section: Resultsmentioning

confidence: 99%

A review of the treatment options for skin rash induced by EGFR-targeted therapies: Evidence from randomized clinical trials and a metaanalysis

Ocvirk¹,

Heeger²,

McCloud³

et al. 2013

Radiology and Oncology

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BackgroundAgents targeting the epidermal growth factor receptor (EGFR) are amongst the most extensively used of the targeted agents in the therapy of some of the most common solid tumors. Although they avoid many of the classic side effects associated with cytotoxic chemotherapy, they are associated with unpleasant cutaneous toxicities which can affect treatment compliance and impinge on patient quality of life. To date, despite a plethora of consensus recommendations, expert opinions and reviews, there is a paucity of evidence-based guidance for the management of the skin rash that occurs in the treatment of patients receiving EGFR-targeted therapies.MethodsA literature search was conducted as a first step towards investigating not only an evidence-based approach to the management of skin rash, but also with a view to designing future randomized trials.ResultsThe literature search identified seven randomized trials and a meta-analysis was conducted using the data from four of these trials involving oral antibiotics. The meta-analysis of the data from these four trials suggests that prophylactic antibiotics might reduce the relative risk of severe rash associated with EGFR-targeted agents by 42–77%. Vitamin K cream was also identified as having a potential role in the management EGFR-targeted agent induced rash.ConclusionsThis review and meta-analysis clearly identify the need for further randomized studies of the role of oral antibiotics in this setting. The results of the ongoing randomized trials of the topical application of vitamin K cream plus or minus doxycycline and employing prophylactic versus reactive strategies are eagerly awaited.

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“…Apoptosis is not only necessary in abnormal and/or injured cells but also for this epidermal sloughing process. Skin immunity and barrier formation are most crucial for defending the body from the external environment and for healing wounds; recent studies have begun addressing vitamin D’s position in innate immunity and wound healing within the skin [9,56]. …”

Section: Discussionmentioning

confidence: 99%

“…Such skin pathologies may be similar to those in humans, which are often associated with altered antimicrobial production, inflammation, increased proliferation with decreased differentiation, and disrupted cytokine/growth factor signaling [56,63]. All of these are well known functions of 1,25D3, the reason this pathway is implicated in several hyperproliferative and inflammatory skin conditions (e.g.…”

Section: Discussionmentioning

confidence: 99%

The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin

Ellis

Gattoni‐Celli

Mancia

et al. 2009

Developmental & Comparative Immunology

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The Atlantic bottlenose dolphin has attracted attention due to the evident impact that environmental stressors have taken on its health. In order to better understand the mechanisms linking environmental health with dolphin health, we have established cell cultures from dolphin skin as in vitro tools for molecular evaluations. The vitamin D3 pathway is one mechanism of interest because of its well established chemopreventative and immunomodulatory properties in terrestrial mammals. On the other hand, little is known of the physiological role of this molecule in aquatic animals. 1,25-dihydroxyvitamin D3 (1,25D3), the bioactive and hormonal form of vitamin D3, exerts its biological function by binding to the vitamin D receptor (VDR), a ligand-activated regulator of gene transcription. Therefore, we investigated the transcriptomic changes induced by 1,25D3 administration in dolphin skin cells. Identification of specific genes activated by 1,25D3 has provided clues to the physiological function of the vitamin D3 pathway in the dolphin. We found that exposure of the cells to 1,25D3 upregulated transactivation of a vitamin D-sensitive promoter. cDNA microarray analysis, using a novel dolphin array, identified specific gene targets within this pathway, and real-time PCR (qPCR) confirmed the enhanced expression of select genes of interest. These transcriptional changes correlated with an increase in VDR levels. This is the first report of the presence and activation of the vitamin D3 pathway in a marine mammal, and our experimental results demonstrate a number of similarities to terrestrial animals. Conservation of this pathway in the Atlantic bottlenose dolphin is consistent with the importance of nonclassic functions of vitamin D3, such as its role in innate immunity, similar to what has been demonstrated in other mammals.

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The Epidermal Vitamin D System and Innate Immunity: Some More Light Shed on This Unique Photoendocrine System?

Cited by 12 publications

References 62 publications

Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future

A review of the treatment options for skin rash induced by EGFR-targeted therapies: Evidence from randomized clinical trials and a metaanalysis

The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin

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