The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses

Ramsoomair, Christian K.; Ceccarelli, Michele; Heiss, John D.; Shah, Ashish H.

doi:10.1186/s12967-023-04725-z

Cited by 5 publications

(2 citation statements)

References 144 publications

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“…Anti-HIV retroviral drugs have demonstrated some benefit in ALS and they decrease HERV-K load after 24 weeks of therapy [194]. A strategy to augment tumor antigenicity via HERV-induced inflammation is another approach to fight cancer [149] including gliomas [195]. Moreover, it has been suggested that various tumors will be responsive to vaccines against HERV-K Gag [196].…”

Section: Treating Map/hervmentioning

confidence: 99%

Mycobacterium paratuberculosis: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

Dow,

Pierce,

Sechi

2024

Preprint

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Human endogenous retroviruses (HERV) are remnants of ancient retroviral infections that, over millions of years, became integrated into the human genome. While normally inactive, environmental stimuli such as infections have contributed to the transcriptional reactivation of HERV promoting pathological conditions including the development of autoimmunity, neurodegenerative disease and cancer. What infections then trigger HERV activation? Mycobacterium avium subspecies paratuberculosis (MAP) is a pluripotent driver of human disease. Aside from granulomatous diseases Crohn’s, sarcoidosis and Blau syndrome, MAP is associated with autoimmune disease: type one diabetes (T1D), multiple sclerosis (MS), rheumatoid arthritis and autoimmune thyroiditis. MAP is also associated with Parkinson’s disease. Autoimmune diabetes, multiple sclerosis and rheumatoid arthritis are the diseases with the strongest MAP/HERV association. There are several other diseases associated with HERV activation including diseases whose epidemiology and/or pathology would prompt speculation for a causal role of MAP. These include non-solar uveal melanoma, colon cancer, glioblastoma and amyotrophic lateral sclerosis (ALS). This article further points to MAP infection as a contributor to autoimmunity, neurodegenerative disease and cancer via unsilencing of HERV. We examine the link between the ever-increasing number of MAP- associated diseases, the MAP/HERV intersection with these diverse medical conditions and propose treatment opportunities based upon this association.

show abstract

Section: Treating Map/hervmentioning

confidence: 99%

Mycobacterium paratuberculosis: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

Dow,

Pierce,

Sechi

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…A strategy to augment tumor antigenicity via HERV-induced inflammation is another approach to fight cancer [149] including gliomas [195]. Moreover, it has been suggested that various tumors will be responsive to vaccines against HERV-K Gag [196]. Thus, HERV-targeting agents could provide a broad new class of therapeutics for autoimmunity, neurodegeneration and cancer.…”

Section: Treating Map/hervmentioning

confidence: 99%

Mycobacterium paratuberculosis: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

Dow,

Pierce,

Sechi

2024

Preprint

View full text Add to dashboard Cite

Human endogenous retroviruses (HERV) are remnants of ancient retroviral infections that, over millions of years, became integrated into the human genome. While normally inactive, environmental stimuli such as infections have contributed to the transcriptional reactivation of HERV promoting pathological conditions including the devel-opment of autoimmunity, neurodegenerative disease and cancer. What infections then trigger HERV activation? Mycobacterium avium subspecies paratuberculosis (MAP) is a pluripotent driver of human disease. Aside from granu-lomatous diseases Crohn’s, sarcoidosis and Blau syndrome, MAP is associated with autoimmune disease: type one diabetes (T1D), multiple sclerosis (MS), rheumatoid arthritis and autoimmune thyroiditis. MAP is also associated with Parkinson’s disease. Autoimmune diabetes, multiple sclerosis and rheumatoid arthritis are the diseases with the strongest MAP/HERV association. There are several other diseases associated with HERV activation including diseases whose epidemiology and/or pathology would prompt speculation for a causal role of MAP. These include non-solar uveal melanoma, colon cancer, glioblastoma and amyotrophic lateral sclerosis (ALS). This article further points to MAP infection as a contributor to autoimmunity, neurodegenerative disease and cancer via unsilencing of HERV. We examine the link between the ever-increasing number of MAP- associated diseases, the MAP/HERV intersection with these diverse medical conditions and propose treatment opportunities based upon this association.

show abstract

Unveiling the role of RNA methylation in glioma: Mechanisms, prognostic biomarkers, and therapeutic targets

Xu,

Yang,

Wang

et al. 2024

Cellular Signalling

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The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses

Cited by 5 publications

References 144 publications

<em>Mycobacterium paratuberculosis</em>: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

<em>Mycobacterium paratuberculosis</em>: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

<em>Mycobacterium paratuberculosis</em>: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

Unveiling the role of RNA methylation in glioma: Mechanisms, prognostic biomarkers, and therapeutic targets

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