THE EQUILIBRATION OF RADIOSODIUM (Na24), RADIOPOTASSIUM (K42), AND DEUTERIUM OXIDE (D2O) IN HYDROPIC HUMAN SUBJECTS 1

O'Meara, Maurice P.; Birkenfeld, L. W.; Gotch, Frank A.; Edelman, Isidore S.

doi:10.1172/jci103483

Cited by 50 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They suggested that heart failure invokes an increase in body sodium content out of proportion to the gain of extracellular water. Similar comparative stud-ies with respect to body potassium have not yet been reported, although low values have been noted in chronically ill patients with and without edema (15,16,18,(20)(21)(22)(23). The lack of a practical method for estimating body fat, however, makes it difficult to decide whether these findings represent a loss of cell mass or a decrease in the proportion of potassium to cell mass.…”

supporting

confidence: 55%

“…Similar studies in a variety of disease states have shown changes in body composition characterized by decreases in body fat, cell mass, and body potassium, and increases in body sodium and water, when these values are expressed on a body weight basis (11)(12)(13)(14)(15)(16). While this pattern of change in composition is apparent in chronically ill or acutely stressed patients who are free of edema, it is particularly pronounced in edematous subjects (13,14,(16)(17)(18). These studies, however, have not indicated whether there are changes in the proportions of body sodium, potassium, and water which are specific for a disease state.…”

mentioning

confidence: 99%

“…It has recently been shown that equilibrium of isotope distribution may be delayed in edematous subjects (18). The variations of body composition with sex (5,8,16), age (5,7,8,24,25), nutrition (5,7,12,16), and treatment (15,19,22,26) make it important to assure that changes ascribed to a disease are not a reflection of some of these other factors.…”

mentioning

confidence: 99%

“…The analytic procedures for chemical and radioactive assay have been described in detail (18). Potassium4 was counted with an end-window Geiger-Muller tube, and Na' with a well-type sodium iodide scintillation counter.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Total Exchangeable Sodium, Total Exchangeable Potassium, and Total Body Water in Edematous Patients With Cirrhosis of the Liver and Congestive Heart Failure1

Birkenfeld¹,

Leibman²,

O'Meara³

et al. 1958

J. Clin. Invest.

Self Cite

102

View full text Add to dashboard Cite

supporting

confidence: 55%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Total Exchangeable Sodium, Total Exchangeable Potassium, and Total Body Water in Edematous Patients With Cirrhosis of the Liver and Congestive Heart Failure1

Birkenfeld¹,

Leibman²,

O'Meara³

et al. 1958

J. Clin. Invest.

Self Cite

102

View full text Add to dashboard Cite

“…Recently, O'Meara, Birkenfeld, Gotch, and Edelman (8) have found that the mixing of administered K42 is prolonged in subjects who have edema. It was concluded by these authors that equilibration times should be extended to 40 hours when measuring Ke in sick patients.…”

mentioning

confidence: 99%

Total Exchangeable Potassium and Chloride and Total Body Water in Healthy Men of Varying Fat Content

Boling¹,

Taylor²,

Entenman³

et al. 1962

J. Clin. Invest.

View full text Add to dashboard Cite

During the past few years various attempts have been made to develop an improved standard of reference for comparison of those parameters of body composition which refer largely to lean body mass. Weir measured carcass chloride in dogs and found poor correlation between carcass chloride and body weight (1). He found, however, better correlation between carcass chloride and fatfree carcass weight (2). Corsa and co-workers (3) pointed out the theoretical desirability of relating total exchangeable potassium (Ke) to lean body mass or to a parameter closely related to lean body mass. Cheek and West (4) found that Ke, carcass potassium, Cle, and carcass chloride in rats were closely related to both fat-free carcass weight and to total body water (TBW). Muldowney, Crooks, and Bluhm (5, 6) measured Ke, Cle, antipyrine space, plasma volume, and red cell mass in adult human beings and compared all these except antipyrine space with lean body mass, derived from antipyrine space, and with creatinine excretion. They found that the correlation of each parameter with the derived lean body mass was significantly better than its correlation with body weight. McMurrey and co-workers (7) measured total exchangeable chloride, potassium, and sodium (Cle, Ke, and Nae), red cell mass, plasma volume, and TBW in a group of ten healthy men and ten healthy women. Their data show much better correlation of these parameters with TBW than with body weight.Recently, O'Meara, Birkenfeld, Gotch, and Edelman (8) have found that the mixing of administered K42 is prolonged in subjects who have edema. It was concluded by these authors that equilibration times should be extended to 40 hours when measuring Ke in sick patients. Because of the short half-life of K42, this makes the measurement * Present address: Medical Service, Veterans Administration Hospital, Boston, Mass. much more difficult to perform. Recently, however, apparatus has become available that makes it convenient to measure Ke after a mixing time of 40 hours, using a dose of only 50 microcuries of K42 (9, 10).In order to study the inter-relationships of parameters of body composition, these should be determined simultaneously in each subject. Data permitting such comparisons for healthy adults are scarce. Also, values for Ke in healthy adults with equilibration times of 40 hours are few. Finally, the effect of obesity on these inter-relationships is not known. In order to gather additional values permitting the study of these relationships, the present study was undertaken. Thirty-five healthy men were studied. They were chosen so that a wide range of fat content was encompassed. Simultaneous estimations of TBW, Ke, and Cle were made using tritiated water, K42, and Br52 as the tracers, respectively. The results confirm the close relationships previously reported between the magnitude of Ke and Cle, estimated by Br82, and the magnitude of TBW. The ratio Ke: TBW was significantly higher in muscular men (weightlifters) than in randomly selected or obese men.In addition, the values for t...

show abstract

In Vitro Incorporation of Rb86 by the Erythrocyte as an Index of Intracellular Potassium

Henegar¹

1959

Arch Surg

View full text Add to dashboard Cite

THE EQUILIBRATION OF RADIOSODIUM (Na24), RADIOPOTASSIUM (K42), AND DEUTERIUM OXIDE (D2O) IN HYDROPIC HUMAN SUBJECTS 1

Cited by 50 publications

References 12 publications

Total Exchangeable Sodium, Total Exchangeable Potassium, and Total Body Water in Edematous Patients With Cirrhosis of the Liver and Congestive Heart Failure1

Total Exchangeable Sodium, Total Exchangeable Potassium, and Total Body Water in Edematous Patients With Cirrhosis of the Liver and Congestive Heart Failure1

Total Exchangeable Potassium and Chloride and Total Body Water in Healthy Men of Varying Fat Content

In Vitro Incorporation of Rb86 by the Erythrocyte as an Index of Intracellular Potassium

Contact Info

Product

Resources

About