The ERA-EDTA Registry Annual Report 2018: a summary

Kramer, Anneke; Boenink, Rianne; Stel, Vianda S.; Pablos, Carmen Santiuste de; Tomović, Filip; Golan, Eliezer; Kerschbaum, Julia; Seyahi, Nurhan; Ioanou, Kyriakos; Beltrán, Palma; Zurriaga, Óscar; Magaz, Ángela; Roblero, María Fernanda Slon; Gjorgjievski, Nikola; Gârneaţă, Liliana; Arribas, Francisco Javier Rubio; Galvão, Ana; Bell, Samira; Ots-Rosenberg, Mai; Muñoz-Terol, José Manuel; Winzeler, Rebecca; Hommel, Kristine; Åsberg, Anders; Spustová, Viera; García, María Ángeles; Vazelov, Evgueniy; Finne, Patrik; Dam, Marc A.G.J. ten; Lopot, František; Trujillo-Alemán, Sara; Lassalle, Mathilde; Kolesnyk, М.; Santhakumaran, Shalini; Idrizi, Alma; Andrusev, Anton; Farnés, Jordi Comas; Komissarov, Kirill; Resić, Halima; Pálsson, Runólfur; Kuzema, Viktorija; Bazaga, Maria Angeles Garcia; Žiginskienė, Edita; Stendahl, Maria; Bonthuis, Marjolein; Massy, Ziad A.; Jager, Kitty J.

doi:10.1093/ckj/sfaa271

Cited by 87 publications

(71 citation statements)

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“…In this study, 1st-year mortality of the patients who underwent LKDT in our center was 1.67%. TSN 2019 registry reports revealed that 1st-year mortality 2.85% (9), US 2019 registry reports revealed that 1st-year mortality 2% (10), European Renal Association-European Dialysis, and Transplant Association (ERA-EDTA) 2017 reports showed that 1st-year mortality 1.2% (11), which was also very similar to our results. This study showed that recipient age, dialysis treatment and HLA mismatch numbers are independent risk factors for 1st-year mortality after LDKT.…”

Section: Discussionsupporting

confidence: 90%

First-year mortality in living donor kidney transplantation: twelve-year experience from a single center

Merhametsiz

Demir

Sevmiş

et al. 2021

Journal of Health Sciences and Medicine

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Objective:The mortality was seen in the early period after kidney transplantation is one of the most undesirable consequences of kidney transplant treatment. This study was aimed to evaluate the factors affecting the 1st-year mortality in patients who underwent living donor kidney transplantation (LDKT) in our center. Material and Method: Adult patients who underwent LDKT developed mortality within the 1st-year in our center between 2008 and 2020. Mortality group and the control group are compared according to donor and recipient characteristics. The risk factors that have an adjusted effect on 1st-year mortality after kidney transplantation were evaluated by cox regression survival analysis. Results: Total mortality incidence was 8.35% and the 1st-year mortality incidence was 1.67%. Median dialysis duration (13 months vs. 3 months) was longer in the mortality-group, p=0.022. Cardiovascular disease (CVD) was more common in the mortality-group (50% vs. 31.1%), p=0.037. Median HLA mismatch numbers was higher in the mortality-group (4 vs. 3), p=0.027. According to Model 1, in terms of 1st-year mortality, each 1 year increment in recipient's age increases the mortality by 1.034 times, and dialysis treatment increases the mortality 2.5 times. According to Model 2, in terms of 1st-year mortality, each 1 year increment in recipient's age increase the mortality by 1.039 times, dialysis treatment increases the mortality 2.8 times and each 1 mismatch increase in human leukocyte antigen (HLA) mismatch numbers increases the mortality by 1.3 times. Receiver operating characteristic analysis showed that the moderate predictive power for recipient age was area under the curve (AUC) 0.734 (95% CI 0.623-0.844, p<0.001) and the weak level predictive power AUC was for HLA mismatch 0.639 (95% CI 0.519-0.759, p=0.030) in terms of 1st-year mortality. Conclussion: This study presented that the 1st-year mortality results of our organ transplant center are similar to the national and international literature. We determined recipient age, dialysis treatment and HLA mismatch numbers as independent risk factors affecting 1st-year mortality after LDKT.

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Section: Discussionsupporting

confidence: 90%

First-year mortality in living donor kidney transplantation: twelve-year experience from a single center

Merhametsiz

Demir

Sevmiş

et al. 2021

Journal of Health Sciences and Medicine

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“…End-stage renal disease (ESRS) is a health issue that extends worldwide as it requires long term care and in the same time, is very costly. Prevalence of chronic renal failure increases in various countries (1) .…”

Section: Introductionmentioning

confidence: 99%

The Effects of Educational Interventions on Nurses' Knowledge and Practices in Hemodialysis Unit Regarding Infection Control Practices

Osman

Banna

Sharaf

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Nurses are considered a key element to break the chain of the infection through their adherence to standard precautions. Many factors may hinder nurses' adherence to these precautions as; shortage of nurses, high number of patient ratio, turn-over of nursing staff, lack of staff training, inadequate supplies, patient urgency, time limits and low patients education level regarding infection control. Objective: This study aims to evaluate the effects of educational interventions on nurses' knowledge and practices in Hemodialysis Unit regarding infection control practices. Patients and methods: A quasi-experimental research design (pretest-posttest) was utilized to fulfill the aim of the study. The study was conducted at the Hemodialysis Unit, Alexandria Fever Hospital. All nurses who were involved in providing direct care throughout the three shifts (morning, evening, night), for patients, at the above-mentioned setting, were included in the study (n=30 nurses). Results: No statistical significant relationships were detected between the studied nurses' knowledge levels and their demographic characteristics after application of the educational interventions. Statistical significant relationships were detected between the nurses' age, level of education, and their practices level after application of the educational interventions. The results of the present study highlighted that nearly two thirds of the studied nurses had "poor" overall knowledge and half of them had "poor" overall practices regarding infection prevention, and control practices before application of the educational interventions. Conclusion: Educational nursing interventions had significant positive effects on overall percent improvement of nurses' knowledge, and practice related to infection control in Hemodialysis (HD) Unit Fever Hospital.

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“…Currently, the survival of patients receiving organ transplantation remains unsatisfactory, with a five-year survival of 89.6% ( 75 ), 86.6% ( 76 ), and 77% ( 77 ) in the liver, kidney, and heart transplantation, respectively. Although immunosuppression has been widely used to inhibit acute graft- vs -host disease after organ transplantation ( 78 ), many complications (like heart failure or acute kidney injury) increase morbidity and mortality ( 79 ).…”

Section: Discussionmentioning

confidence: 99%

Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications

Sun

Jiang

et al. 2021

Front. Immunol.

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The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and transplantation failure. Interestingly, although the embryo and placenta are semi-allografts, like transplanted organs, they can induce maternal tolerance and be free of a vigorous immune response. Also, embryo or placenta-related antibodies might adversely affect subsequent organ transplantation despite the immune tolerance during pregnancy. Therefore, the balance between the immune tolerance in maternal-fetal interface and normal infection defense provides a possible desensitization and tolerance strategy to improve transplantation outcomes. A few studies on mechanisms and clinical applications have been performed to explore the relationship between maternal-fetal immune tolerance and organ transplantation. However, up to now, the mechanisms underlying maternal-fetal immune tolerance remain vague. In this review, we provide an overview on the current understanding of immune tolerance mechanisms underlying the maternal-fetal interface, summarize the interconnection between immune tolerance and organ transplantation, and describe the adverse effect of pregnancy alloimmunization on organ transplantation.

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The ERA-EDTA Registry Annual Report 2018: a summary

Cited by 87 publications

References 1 publication

First-year mortality in living donor kidney transplantation: twelve-year experience from a single center

First-year mortality in living donor kidney transplantation: twelve-year experience from a single center

The Effects of Educational Interventions on Nurses' Knowledge and Practices in Hemodialysis Unit Regarding Infection Control Practices

Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications

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