The era of device colonizers:<i>Chryseobacterium indologenes</i>infections from a tertiary care center in North India

Jain, Vidhi; Sahu, Chinmoy; Hussain, Nayani Amrin Fatema Afzal; Ghar, Malay; Prasad, Kashi Nath

doi:10.4103/ijccm.ijccm_24_18

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…C. indologenes is easily distinguished from other nonfermenters by its individual ability to produce indole. 6 In the present study, 9 isolates of C. indologenes were recovered from various samples like ascitic fluid, respiratory secretions and urine which were correlated with the study conducted by Kaur H et al 2 and Vidhi Jain et al 7 The isolate of C. indologenes from ascitic fluid was from a chronic liver disease patient and it was accounted as a true pathogen. Most of the other isolates were from ward patients in this study.…”

Section: Discussionsupporting

confidence: 83%

Increased recognition of Chryseobacterium species as an emerging cause of nosocomial infection at a tertiary care centre in Mangalore

John¹,

Sharma²,

Nayak³

et al. 2018

JIMD

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Background: Chryseobacterium is an environmental inhabitant which is periodically discovered in human specimens. It is one of the prominent pathogens among non-fermentative Gram-negative bacilli. The members of Chryseobacterium genus are mainly noted for their multi-drug resistance. Materials and Methods: Patients admitted in tertiary care centre were examined for 6 months. Chryseobacterium species were isolated from different clinical samples using conventional methods (according to CLSI guidelines) and antibiotic susceptibility patterns were obtained. This study also comprised of associated underlying risk factors, comorbidities and eventually the treatment outcome. Results: A total of 9 isolates of C. indologenes were recovered from specific samples like urine, sputum, pus and ascitic fluid. Among which, four patients had respiratory tract infection, one had chronic liver disease, two had wound infection and in other two, the organism was isolated from the sample of catheterized urine. The two patients were in the intensive care unit and had central lines and indwelling catheter. The common underlying risk factors identified were diabetes, hypertension and coronary artery disease. Conclusion: This case concludes that C. indologenes may cause symptomatic disease in immunocompetent persons with otherwise no associated underlying risk factors.

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Section: Discussionsupporting

confidence: 83%

Increased recognition of Chryseobacterium species as an emerging cause of nosocomial infection at a tertiary care centre in Mangalore

John¹,

Sharma²,

Nayak³

et al. 2018

JIMD

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“…In addition, the result is also in agreement with the result obtained by Chen et al (2013), who evaluated the antimicrobial susceptibility of 113 C. indologenes isolates obtained from 2004 to 2011 and found that 34.4% were susceptible to levofloxacin. Moreso, previous studies carried out by Jain et al (2018) also reported the susceptibility of C. indologenes to levofloxacin to be 98%.…”

Section: Discussionmentioning

confidence: 76%

Prevalence, antibiotic susceptibility pattern and detection of antibiotic-resistant genes in Chryseobacterium indologenes isolated from the hospital environment

A.¹,

Andy²,

Agboke³

et al. 2023

MJM

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Aims:The resistance rate of Chryseobacterium indologenes to commonly available antibiotics is very worrisome. As documented by SENTRY antimicrobial surveillance program, C. indologenes has different antibiotic resistance patterns. This study investigated the prevalence of C. indologenes in the hospital environment and their susceptibility pattern to commonly available antibiotics. Methodology and results: Chryseobacterium indologenes isolates were identified using DNA sequence-based identification method. Evaluation of resistant genes was done using specific primers. Fifty-two (52) isolates met the characteristics for the identification. Chryseobacterium indologenes' prevalence was 5.9%, 7.8% and 7.5% in hospitals 1, 2 and 3, respectively. The in vitro antibiotic susceptibility testing of C. indologenes isolates revealed that some isolates were multidrug-resistant. Some isolates were susceptible to levofloxacin (34.6%), ciprofloxacin (25%), ceftriaxone (19.2%) and gentamicin (13.5%). There was zero susceptibility to imipenem, cefuroxime, amikacin and ceftazidime. The 16s rRNA sequence of C. indologenes isolates showed 99.9% similarity compared with a highly similar sequence from the NCBI nucleotide database. Their evolutionary distances were in agreement with the phylogenetic placement of the 16S rDNA of the isolates, as all the isolates were revealed to be C. indologenes strain Sn6 with accession number KC683715. The resistant genes evaluation revealed that the isolates harbor SHV, TEM, QnrA, QnrS and APH (3')-IIIA genes, as indicated by amplification of those genes on agarose gel electrophoresis. Conclusion, significance and impact of study:The high prevalence of C. indologenes Sn6 and its high degree of resistance observed in this study represent a potential public health risk.

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“…In this study, there was no correlation between the dominant microbiota and the actual bacteremic pathogens. Previously, Bacillus and Flavobacterium have been reported as causes of device-related BSI in patients with signi cant underlying conditions [15][16][17][18][19][20][21][22]. Speci c bacteria such as Arthrobacter, SMB53, Dyella, Paracoccus, and Pedobacter have been reported as dialysis catheter-related infections or CRBSI [23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Biofilm Microbiome in Extracorporeal Membrane Oxygenator Catheters

Kim

Cho

et al. 2020

Preprint

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Background : To assess the relationship between bacteremia and biofilms in extracorporeal membrane oxygenation (ECMO) catheters.Methods: We evaluated the biofilm microbiome of ECMO catheters from adults with (n = 6) and without bacteremia (n = 15). Microbiomes of the catheter biofilms were evaluated by profiling the V3 and V4 regions of bacterial 16s rRNA genes using the Illumina Miseq sequencing platform.Results: In total, 2,548,172 reads, with an average of 121,341 reads per sample, were generated. Although alpha diversity was slightly higher in the non-bacteremic group, it was not statistically significant. Also, there was no difference in beta diversity between the two groups. At the genus level, Delftia was more abundant in the non-bacteremic group, but Bacillus, Flavobacterium, CL0-1, Candidatus, and Xiphinematobacter were more abundant in the bacteremic group. In particular, Arthrobacter, SMB53, Neisseria, Candidatus, Ortrobactrum, Candidatus, Rhabdochlamydia, Deefgae, Dyella, Paracoccus, and Pedobacter were more abundant in the bacteremic group. In a network analysis, compared to the non-bacteremic group, the microbiome of the bacteremic group was very complex. Notably, there was a significant elevation in the secretion system of the non-bacteremic group.Conclusions: Biofilm characteristics in ECMO catheters varied according to the presence or absence of bacteremia.

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The era of device colonizers:Chryseobacterium indologenesinfections from a tertiary care center in North India

Cited by 8 publications

References 8 publications

Increased recognition of Chryseobacterium species as an emerging cause of nosocomial infection at a tertiary care centre in Mangalore

Increased recognition of Chryseobacterium species as an emerging cause of nosocomial infection at a tertiary care centre in Mangalore

Prevalence, antibiotic susceptibility pattern and detection of antibiotic-resistant genes in Chryseobacterium indologenes isolated from the hospital environment

Biofilm Microbiome in Extracorporeal Membrane Oxygenator Catheters

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