The erythrocyte in aging

Cerny, L.C.; Cook, F.B.; Valone, Frank H.

doi:10.1016/0531-5565(72)90008-3

Cited by 11 publications

(2 citation statements)

References 6 publications

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“…Cerny et al 1 found that as human age increased, the deformability of the red cell membrane decreased, resulting in an increased whole blood viscosity. An increase in mean osmotic fragility with a broadening of the erythrocyte fragility distribution has also been shown to accompany human aging 2 …”

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confidence: 99%

Red Blood Cell Glucose‐6‐phosphate Dehydrogenase Activity in Aged Humans

Rodgers

Lichtman²,

Sheff

1983

J American Geriatrics Society

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The enzyme glucose-6-phosphate dehydrogenase (G6PD) was assayed in the circulating erythrocytes of 38 20-to 30-year-old subjects and 29 80- to 90-year-old subjects. The red blood cell G6PD activity of an aged-unbiased erythrocyte population in the young group was found to be significantly higher than in the older group (5.46 +/- 1.06) vs (4.31 +/- 0.99) (P less than 0.001), respectively (mean +/- SD). No significant difference was observed between the mean enzyme values of the male and female subjects in the two age groups. Since the mature red blood cell is devoid of regenerative capabilities, one may propose an explanation for this observation that implicates either an alteration in G6PD synthesis in the erythrocyte precursor cells in aged hosts, and/or the presence of an inhibitory factor that has the effect of decreasing the assayed activity for this enzyme.

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confidence: 99%

Red Blood Cell Glucose‐6‐phosphate Dehydrogenase Activity in Aged Humans

Rodgers

Lichtman²,

Sheff

1983

J American Geriatrics Society

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“…These findings were consistent with those of previous studies. For example, Cerny et al [2] reported that for samples of normocytic, normochromic blood (NNB) 'as age increased, the deformability of the red cell decreased. As a result whole-blood viscosity of NNB is a function of age.…”

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confidence: 99%

Red Cell Shape Changes in the Blood of People 60 Years of Age and Older Imply a Role for Blood Rheology in the Aging Process

Simpson

O’Neill

2003

Gerontology

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Five-drop samples of venous blood, which was fixed immediately, were obtained from 76 males and 91 females who were 60 years of age and older, and did not take part in competitive sport, and from 73 males and 50 females participating in the Golden Oldies Soccer tournament or in the Dunedin Masters’ Games. Most participants were nonsmokers. Those in the competitive group indicated a higher level of activity than those in the noncompetitive group, and the majority of participants indicated high levels of well-being. 30 different medical diagnoses were recorded including hypertension (36 cases), arthritis (17 cases), diabetes (6 cases), angina (6 cases) and coronary heart disease (7 cases). Most samples had high values for flat cells. Increased values for cells with altered margins were found in 7 males and 7 females, while 6 males and 1 female sample had increased values for cells with surface changes. It is concluded that some factor or factors in the aging process are responsible for red cell shape transformation. As high values for flat cells occur in people with chronic disorders, the lack of symptoms or evidence of dysfunction in people over 60 implies that survival is a consequence of having larger than usual capillaries.

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Blood in the Aged

Nicola¹,

Casale²

1983

Geriatrics 2

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The erythrocyte in aging

Cited by 11 publications

References 6 publications

Red Blood Cell Glucose‐6‐phosphate Dehydrogenase Activity in Aged Humans

Red Blood Cell Glucose‐6‐phosphate Dehydrogenase Activity in Aged Humans

Red Cell Shape Changes in the Blood of People 60 Years of Age and Older Imply a Role for Blood Rheology in the Aging Process

Blood in the Aged

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