The ERβ-cAMP signaling pathway regulates estradiol-induced ovine oocyte meiotic arrest

Yang, Bingxue; An, Yang; Yang, Yanyan; Zhao, Yufen; Yu, Kai; Weng, Yu; Du, Chenguang; Li, Haijun; Yu, Boyang

doi:10.1016/j.theriogenology.2023.10.009

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…These steroid hormones are all produced by cholesterol in mitochondria through complex biosynthetic pathways ( Miller, 2013 ; Esmaeilian et al, 2023 ). Estradiol is an endogenous hormone secreted by mature ovarian follicles ( Yang et al, 2023 ), and changes in its level not only play a key role in the regulation of female reproductive development, but also in the development of mammalian bones, brain function and skin health ( Baddela et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of LncRNA Gm2044 in germ cell development

Zhu,

Sun,

et al. 2024

Front. Cell Dev. Biol.

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Germ cell development in mammals is a complex physiological process that involves the proliferation of primordial germ cells, meiosis, and the formation of male and female gametes. Long non-coding RNA (lncRNA) is a type of RNA with more than 200 nucleotides that does not code for proteins. A small number of lncRNAs have been shown to participate in spermatogenesis in the testes and in follicular development in the ovaries, but the role of the vast majority of lncRNAs and their molecular mechanisms still need further study. LncRNA Gm2044 was identified as a differentially expressed lncRNA in mouse spermatogenesis by microarray technology. In mouse testis, lncRNA Gm2044 can act as competing endogenous RNA to regulate SYCP1 expression in GC-2 cells derived from mouse spermatocyte cells, and it can also act as a host gene for miR-202 to regulate RBFOX2 protein expression. In female mouse ovaries, lncRNA Gm2044 regulates 17β-estradiol synthesis through the miRNA-138-5p-Nr5a1 pathway or by interacting with EEF2. In addition, studies suggest that lncRNA Gm2044 is also involved in the progression of reproductive system diseases such as male nonobstructive azoospermia. Here, we summarize the roles and molecular mechanisms of lncRNA Gm2044 in male and female gametogenesis and its potential role in some infertility disorders.

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Section: Introductionmentioning

confidence: 99%

Mechanism of LncRNA Gm2044 in germ cell development

Zhu,

Sun,

et al. 2024

Front. Cell Dev. Biol.

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Effect of the gonadotropin surge on steroid receptor regulation in preovulatory follicles and newly formed corpora lutea in the cow

Berisha,

Thaqi,

Schams

et al. 2024

Domestic Animal Endocrinology

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Epigenetic and transcriptional regulation of ovarian development altered inErβ^KOovaries

Mohamadi,

Vo,

Sharma

et al. 2024

Preprint

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We analyzed the transcriptome of wildtype and estrogen receptor β knockout (ErβKO) rat ovaries during the early postnatal period and detected remarkable changes in epigenetic regulators and transcription factors. Compared to postnatal day (PD) 4.5 wildtype ovaries, 17 differentially expressed epigenetic regulators (DEERs), and 23 differentially expressed transcription factors (DETFs) were detected in PD6.5 wildtype ovaries. Subsequently, compared to PD 6.5 wildtype ovaries, 24 DEERs and 68 DETFs were detected in PD8.5 ovaries. Changes in DEERs and DEFTs resulted in 581 differentially expressed downstream genes (DEDGs) in PD6.5 and 920 DEDGs in wildtype PD8.5 ovaries. The DEERs, DETFs, and DEDGs in wildtype ovaries represented primordial follicle activation (PFA) and development of the first-wave follicles because the second-wave follicles remain dormant during this period. However, the changes in DEERs, DETFs, and DEDGs during this postnatal period were markedly different in ErβKO rat ovaries, which suffered from in-creased PFA in both waves. Compared to 17 DEERs and 23 DETFs in wildtype, 46 DEERs and 55 DETFs were identified in PD 6.5 ErβKO ovaries. The differences were more remarkable in PD 8.5 ErβKO ovaries; compared to 24 DEERS and 68 DETFs in wildtype, only 8 DEERs and 10 DETFs were detected in ErβKO ovaries. Such dysregulation resulted in altered DEDGs in PD 6.5 (581 vs. 744) and in PD8.5 (920 vs. 191) ErβKO ovaries. These findings also suggest that the number of DEDGs depends directly on the numbers of DEERS and DETFs. In addition to the quantitative differences in DEERs and DETFs between the wildtype and ErβKO ovaries, we detected distinct differences in the identities of the regulators. Our observations indicate that loss of ERβ dysregulates the epigenetic regulators and transcription factors in ErβKO ovaries, which disrupts the downstream genes in ovarian follicles and increases follicle activation.

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The ERβ-cAMP signaling pathway regulates estradiol-induced ovine oocyte meiotic arrest

Cited by 4 publications

References 43 publications

Mechanism of LncRNA Gm2044 in germ cell development

Mechanism of LncRNA Gm2044 in germ cell development

Effect of the gonadotropin surge on steroid receptor regulation in preovulatory follicles and newly formed corpora lutea in the cow

Epigenetic and transcriptional regulation of ovarian development altered inErβ^KOovaries

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The ERβ-cAMP signaling pathway regulates estradiol-induced ovine oocyte meiotic arrest

Cited by 4 publications

References 43 publications

Mechanism of LncRNA Gm2044 in germ cell development

Mechanism of LncRNA Gm2044 in germ cell development

Effect of the gonadotropin surge on steroid receptor regulation in preovulatory follicles and newly formed corpora lutea in the cow

Epigenetic and transcriptional regulation of ovarian development altered inErβKOovaries

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Epigenetic and transcriptional regulation of ovarian development altered inErβ^KOovaries