The eS26 protein is involved in the formation of a nucleophosmin binding site on the human 40S ribosomal subunit

Иванов, А. В.; Gopanenko, Alexander V.; Malygin, Alexey A.; Карпова, Г. Г.

doi:10.1016/j.bbapap.2018.03.004

Cited by 4 publications

(3 citation statements)

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“…RPS26 is a ribosomal protein with 115 amino acids. It is an indispensable component of the 40S subunit, which is located close to the mRNA exit site region [12]. RPS26 was demonstrated to regulate the transactivation activity of tumor suppressor p53, which is a transcription factor for genes involved in cell cycle arrest, apoptosis and cellular senescence under stress environments [13].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, RPS26 was documented to be involved in mRNA-specific translation by recognition of the Kozak sequence [13]. The biogenesis of ribosomes might also be affected by RPS26, since a study shows that RPS26 was implicated in the formation of a nucleophosmin [12]. The translation of apoptosis-related protein, biogenesis of ribosomes and mRNA-specific translation may all be implicated in the pathology of DBA10.…”

Section: Discussionmentioning

confidence: 99%

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Identification of a novel RPS26 nonsense mutation in a Chinese Diamond-Blackfan Anemia patient

2019

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Background Diamond-Blackfan anemia (DBA), a congenital pure red cell aplasia (PRCA), is characterized by normochromic macrocytic anemia, reticulocytopenia, and nearly absent erythroid progenitors in the bone marrow. DBA10, a subset of DBA, is an autosomal dominant disease caused by a mutation in RPS26 . So far, there are 30 disease-causing variants in RPS26 being reported, however, only three of them are small insert mutations. Case presentation Here we report a three-month Chinese boy who presents with anemia from postnatal day 2. He was suspected to have Diamond-Blackfan anemia, according to the clinical result. Thus, whole-exome sequencing was performed for precise diagnosis. Conclusion Here, a novel insert mutation c.96dupG in RPS26 was identified by whole-exome sequencing, which caused neonatal DBA in a Chinese boy. This is the first case report of a Chinese DBA10 patient who carries a small insertion in the RPS26 gene. These findings expand the mutation diversity of RPS26 and demonstrate the clinical presentations of the Chinese DBA10 patient. Electronic supplementary material The online version of this article (10.1186/s12881-019-0848-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of a novel RPS26 nonsense mutation in a Chinese Diamond-Blackfan Anemia patient

2019

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“…RPS26 is mapped to human chromosome 12q13.2 and encodes a ribosome protein, which is a component of the ribosome 40S subunit [53]. Whole genome sequencing study of CD4 + T and CD8 + T cells showed that the inappropriate activation of T cells is associated with the occurrence and progression of autoimmune diseases and is accompanied by the specific expression of RPS26 gene [54].…”

Section: T-cell Features Associated With the Severity Of Covid-19mentioning

confidence: 99%

Identification of Gene Markers Associated with COVID-19 Severity and Recovery in Different Immune Cell Subtypes

Ren

Gao

Zhou

et al. 2023

Biology

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As COVID-19 develops, dynamic changes occur in the patient’s immune system. Changes in molecular levels in different immune cells can reflect the course of COVID-19. This study aims to uncover the molecular characteristics of different immune cell subpopulations at different stages of COVID-19. We designed a machine learning workflow to analyze scRNA-seq data of three immune cell types (B, T, and myeloid cells) in four levels of COVID-19 severity/outcome. The datasets for three cell types included 403,700 B-cell, 634,595 T-cell, and 346,547 myeloid cell samples. Each cell subtype was divided into four groups, control, convalescence, progression mild/moderate, and progression severe/critical, and each immune cell contained 27,943 gene features. A feature analysis procedure was applied to the data of each cell type. Irrelevant features were first excluded according to their relevance to the target variable measured by mutual information. Then, four ranking algorithms (last absolute shrinkage and selection operator, light gradient boosting machine, Monte Carlo feature selection, and max-relevance and min-redundancy) were adopted to analyze the remaining features, resulting in four feature lists. These lists were fed into the incremental feature selection, incorporating three classification algorithms (decision tree, k-nearest neighbor, and random forest) to extract key gene features and construct classifiers with superior performance. The results confirmed that genes such as PFN1, RPS26, and FTH1 played important roles in SARS-CoV-2 infection. These findings provide a useful reference for the understanding of the ongoing effect of COVID-19 development on the immune system.

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Tetrapeptide 60–63 of human ribosomal protein uS3 is crucial for translation initiation

Babaylova

Malygin

Gopanenko

et al. 2019

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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The eS26 protein is involved in the formation of a nucleophosmin binding site on the human 40S ribosomal subunit

Cited by 4 publications

References 36 publications

Identification of a novel RPS26 nonsense mutation in a Chinese Diamond-Blackfan Anemia patient

Identification of a novel RPS26 nonsense mutation in a Chinese Diamond-Blackfan Anemia patient

Identification of Gene Markers Associated with COVID-19 Severity and Recovery in Different Immune Cell Subtypes

Tetrapeptide 60–63 of human ribosomal protein uS3 is crucial for translation initiation

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