The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice

Sun, Lili; Zong, Shao-Bo; Li, Jiachun; Lv, Yao-Zhong; Liu, Lina; Wang, Zhengzhong; Zhou, Jun; Cao, Liang; Kou, Junping; Xiao, Wei

doi:10.1016/j.jep.2016.10.064

Cited by 55 publications

(34 citation statements)

References 28 publications

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“…The identification of the analyzed compounds was accomplished by comparing their mass spectra with those of authentic compounds available from the computerized spectral database (NIST). The retention index (RI) of each component was measured by taking n ‐alkanes as a control …”

Section: Methodsmentioning

confidence: 99%

Fungicidal Activity of Essential Oils from Cinnamomum cassia against the Pathogenic Fungi of Panax notoginseng Diseases

Chen

et al. 2019

Chemistry & Biodiversity

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The frequent disease of Panax notoginseng caused by the pathogenic fungi in field cultivation has become the major threaten to the sustainable development of it. The present study was conducted to find natural agent with potential inhibition against pathogen. Therefore, the inhibitory effects of Cinnamomum cassia (L.) J.Presl essential oils (EOs) against P. notoginseng associated pathogenic fungi were conducted both in vitro and in vivo experiments. The results of the Oxford cup test revealed that C. cassia dry bark EO (50 mg/mL) had significant inhibitory activity on the growth of all tested fungi, and the growth of various pathogens was completely inhibited, except for that of Fusarium solani. Therefore, the constituents of C. cassia EOs were analyzed by GC/MS, and the research demonstrated that the main constituents of C. cassia dry bark EO were trans‐cinnamaldehyde (75.65 %), (E)‐2‐methoxycinnamaldehyde (6.08 %), cinnamaldehyde (3.47 %) and cinnamyl acetate (1.02 %). The MIC results showed that C. cassia dry bark EO and the main compounds had good antifungal effect on the tested strains, and the inhibitory effect was similar to that of hymexazol (chemical pesticide). By analyzing the value of the fraction inhibitory concentration index (FICI), additive effects, irrelevant effects and synergistic effects were observed after the mixture of hymexazol against various pathogens. Moreover, in vivo model showed that C. cassia dry bark EO could reduce the occurrence of anthrax in P. notoginseng. To widen the resources of C. cassia available, the compositions of both C. cassia fresh bark and leaf EOs were also tested and many common compositions existed among them. Taken together, it was concluded that C. cassia EO had the potential use in the field to reduce the pathogenic disease.

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Section: Methodsmentioning

confidence: 99%

Fungicidal Activity of Essential Oils from Cinnamomum cassia against the Pathogenic Fungi of Panax notoginseng Diseases

Chen

et al. 2019

Chemistry & Biodiversity

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“…Cinnamomum cassia essential oil was able to reduce the expression of COX-2, evidencing the anti-inflammatory effect. [24] The oil obtained from fruits of the species Cinnamo-mum insularimontanum, as well as citral, the major compound, reduced edematous response in ear edema test in mice. [25] Schinus terebinthifolia oil was able to reduce markers of local inflammation and to increase collagen replacement in wounds inflicted on rats.…”

Section: Antichemotactic Activitymentioning

confidence: 99%

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Maciel

Lacerda

Danielli

et al. 2019

Chemistry & Biodiversity

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The purpose of this work was to determine the chemical composition and evaluate the antichemotactic, antioxidant, and antifungal activities of the essential oil obtained from the species Cryptocarya aschersoniana Mez, Cinnamomum amoenum (Ness & Mart.) Kosterm., and Schinus terebinthifolia Raddi, as well as the combination of C. aschersoniana essential oil and terbinafine against isolates of dermatophytes. Allo‐aromadendrene, bicyclogermacrene, and germacrene B were identified as major compounds in essential oils. The essential oil of C. aschersoniana shown 100 % inhibitory effect on leukocyte migration at the concentration of 10 μg/mL while S. terebinthifolia oil presented 80.1 % inhibitory effect at the same concentration. Only S. terebinthifolia oil possessed free‐radical‐scavenging activity which indicates its antioxidant capacity. The essential oils were also tested against fungal isolates of dermatophyte species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum), resulting in MIC ranging from 125 μg/mL to over 500 μg/mL. C. aschersoniana oil combined with terbinafine resulted in an additive interaction effect. In this case, the essential oil may act as a complement to conventional therapy for the topical treatment of superficial fungal infections, mainly because it is associated with an anti‐inflammatory effect.

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“…Cinnamaldehyde activated the NRF2/HO‐1 pathway and significantly alleviated the production of reactive oxygen species in keratinocytes (Patra, Jana, Mandal, & Bhattacharjee, ). Essential oils extracted from C. cassia Presl had antinociceptive and anti‐inflammatory properties and decreased the levels of cytokines, TNF‐α, IL‐1β, and prostaglandin E2 in carrageenan‐induced mouse paw skin tissue (Sun et al, ). Cinnamaldehyde inhibited proliferation of colorectal cancer cells SW480, HCT116, and LoVo; human breast cancer cells MCF‐7; and human non‐small lung cancer cells (Li, Teng, et al, ; Rad et al, ; Wu et al, ).…”

Section: Discussionmentioning

confidence: 99%

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Deng

Sun

2018

Phytotherapy Research

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The aims of this study were to evaluate the efficacy of herbal medicine for the prevention and management of hand-foot syndrome (HFS) induced by fluoropyrimidines and to identify herbs associated with HFS alleviation for further research. The PubMed, Cochrane, Springer, China National Knowledge Infrastructure, and Wanfang databases were searched up to May 2017 for randomized controlled trials (RCTs) that evaluated herbal medicine for relieving HFS in patients undergoing fluoropyrimidine-based chemotherapy. Study evaluation and synthesis methods were in accordance with the Cochrane Handbook, and data were analyzed using RevMan 5.3. In total, 35 RCTs (2,668 participants) were included. Meta-analysis showed that the addition of herbal medicine significantly reduced the incidences of all-grade and high-grade HFS. The total effective rate and complete remission rate of HFS patients increased significantly with herbal medicine arm. Further sensitivity analysis identified Paeoniae Radix Alba, Carthami Flos, Cinnamomi Ramulus, and Glycyrrhizae Radix et Rhizoma as being consistently associated with significant reductions in HFS incidence without important heterogeneity. However, the lack of blinding in most studies may have led to overestimation of these effects. More high-quality RCTs and experimental research are needed to confirm and investigate the efficacy of the herbs identified in this study.

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The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice

Cited by 55 publications

References 28 publications

Fungicidal Activity of Essential Oils from Cinnamomum cassia against the Pathogenic Fungi of Panax notoginseng Diseases

Fungicidal Activity of Essential Oils from Cinnamomum cassia against the Pathogenic Fungi of Panax notoginseng Diseases

Antichemotactic and Antifungal Action of the Essential Oils from Cryptocarya aschersoniana, Schinus terebinthifolia, and Cinnamomum amoenum

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

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